scholarly journals Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis in AIDS Patient

Cureus ◽  
2021 ◽  
Author(s):  
Raed Atiyat ◽  
Riyashat Kazmi ◽  
Krunal Trivedi ◽  
Hamid S Shaaban
Keyword(s):  
Hemophagocytic Lymphohistiocytosis ◽  
Disseminated Histoplasmosis

scholarly journals Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis in Rheumatologic Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Yael Kusne ◽  
Michael Christiansen ◽  
Christopher Conley ◽  
Juan Gea-Banacloche ◽  
Ayan Sen
Keyword(s):  
Hemophagocytic Lymphohistiocytosis ◽  
Pediatric Patients ◽  
Histoplasma Capsulatum ◽  
Hematologic Malignancies ◽  
Rapid Diagnosis ◽  
Rheumatologic Disease ◽  
Disseminated Histoplasmosis ◽  
Serious Infections ◽  
Time To Diagnosis ◽  
Prompt Diagnosis

Background. Hemophagocytic lymphohistiocytosis (HLH) was originally described in pediatric patients presenting with fever, hepatosplenomegaly, and blood cell abnormalities. Later, HLH was recognized to occur in adults, often associated with hematologic malignancies or serious infections. Conclusion. Patients presenting with HLH are critically ill, and rapid diagnosis is key. In adults, the search for the trigger must begin promptly as time to diagnosis effects survival. The underlying trigger in our patients was Histoplasma capsulatum infection, which is rare in the southwestern United States. Prompt diagnosis led to recovery in one patient, while the other did not survive.

scholarly journals Hemophagocytic Lymphohistiocytosis and Progressive Disseminated Histoplasmosis

2016 ◽  
Vol 22 (6) ◽  
pp. 1119-1121 ◽  
Author(s):  
Kenice Ferguson-Paul ◽  
Spencer Mangum ◽  
Ashley Porter ◽  
Vasiliki Leventaki ◽  
Patrick Campbell ◽  
...  
Keyword(s):  
Hemophagocytic Lymphohistiocytosis ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis

scholarly journals Hemophagocytic Lymphohistiocytosis Secondary to Human Immunodeficiency Virus-Associated Histoplasmosis

2015 ◽  
Vol 2 (4) ◽  
Author(s):  
Anthony A. Castelli ◽  
David G. Rosenthal ◽  
Rachel Bender Ignacio ◽  
Helen Y. Chu
Keyword(s):  
Escherichia Coli ◽  
Human Immunodeficiency Virus ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Mycobacterium Avium Complex ◽  
Multiorgan Failure ◽  
Rapid Diagnosis ◽  
Disseminated Histoplasmosis ◽  
Immunodeficiency Virus ◽  
Underlying Disorder ◽  
Immunocompromised Hosts

Abstract Hemophagocytic lymphohistiocytosis (HLH) in immunocompromised hosts is a fulminant syndrome of immune activation with high rates of mortality that may be triggered by infections or immunodeficiency. Rapid diagnosis and treatment of the underlying disorder is necessary to prevent progression to multiorgan failure and death. We report a case of HLH in a patient with human immunodeficiency virus, disseminated histoplasmosis, Mycobacterium avium complex, and Escherichia coli bacteremia. We discuss management of acutely ill patients with HLH and treatment of the underlying infection versus initiation of HLH-specific chemotherapy.

Hemophagocytic lymphohistiocytosis in an HIV-positive patient with concomitant disseminated histoplasmosis

2018 ◽  
Vol 29 (9) ◽  
pp. 925-928 ◽  
Author(s):  
Nisha Loganantharaj ◽  
Brianna Oliver ◽  
Taylor Smith ◽  
Rachna Jetly ◽  
Lee Engel ◽  
...  
Keyword(s):  
Clinical Improvement ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Ferritin Level ◽  
Positive Patient ◽  
Hiv Positive ◽  
Laboratory Studies ◽  
Disseminated Histoplasmosis

A 46-year-old Dominican man, known to have HIV, presented with constitutional symptoms of two week's duration. The patient was found to have cytopenias, significantly elevated ferritin level and lymphadenopathy. Biopsies and laboratory studies met the criteria for hemophagocytic lymphohistiocytosis (HLH). A concomitant diagnosis of histoplasmosis was confirmed as the trigger for HLH and treatment resulted in clinical improvement and resolution of symptoms.

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