scholarly journals Analysis of Risk Factors and Association of Cluster of Differentiation (CD) Markers With Conventional Markers in Delayed Fracture Related Infection for Closed Fracture

Cureus ◽  
2021 ◽  
Author(s):  
Archana Raikwar ◽  
Ajai Singh ◽  
Vikas Verma ◽  
Abbas Ali Mehdi ◽  
Narendra Singh Kushwaha ◽  
...  
Keyword(s):  
Risk Factors ◽  
Closed Fracture ◽  
Delayed Fracture ◽  
Cluster Of Differentiation ◽  
Cd Markers

Expression of Blood Cells Associated CD Markers and Cardiovascular Diseases: Clinical Applications in Prognosis

2019 ◽  
Author(s):  
Habib Haybar ◽  
Masumeh Maleki Behzad ◽  
Saeid Shahrabi ◽  
Narges Ansari ◽  
Najmaldin Saki
Keyword(s):  
Cardiovascular Diseases ◽  
Blood Cells ◽  
English Language ◽  
Relevant Literature ◽  
Differentiation Markers ◽  
Pubmed Search ◽  
And Function ◽  
Cd Marker ◽  
Cluster Of Differentiation ◽  
Cd Markers

Abstract Background Cardiovascular diseases (CVDs) are a major cause of mortality worldwide. The results of various studies have shown that abnormality in the frequency and function of blood cells can be involved in CVD complications. In this review, we have focused on abnormalities in the expression of the CD (cluster of differentiation) markers of blood cells to assess the association of these abnormalities with CVD prognosis. Methods We identified the relevant literature through a PubMed search (1990–2018) of English-language articles using the terms “Cardiovascular diseases”, “CD markers”, “leukocytes”, “platelets”, and “endothelial cells”. Results There is a variety of mechanisms for the effect of CD-marker expressions on CVDs prognosis, ranging from proinflammatory processes to dysfunctional effects in blood cells. Conclusion Considering the possible effects of CD-marker expression on CVDs prognosis, particularly prognosis of acute myocardial infarction and atherosclerosis, long-term studies in large cohorts are required to identify the prognostic value of CD markers and to target them with appropriate therapeutic agents.

scholarly journals Soluble cluster of differentiation 36 concentrations are not associated with cardiovascular risk factors in middle-aged subjects

2016 ◽  
Vol 4 (5) ◽  
pp. 642-648 ◽  
Author(s):  
MOHAMMAD J. ALKHATATBEH ◽  
NEHAD M. AYOUB ◽  
NIZAR M. MHAIDAT ◽  
NESREEN A. SAADEH ◽  
LISA F. LINCZ
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Middle Aged ◽  
Aged Subjects ◽  
Cluster Of Differentiation

scholarly journals Porcine cluster of differentiation (CD) markers 2018 update

2018 ◽  
Vol 118 ◽  
pp. 199-246 ◽  
Author(s):  
Harry D. Dawson ◽  
Joan K. Lunney
Keyword(s):  
Cluster Of Differentiation ◽  
Cd Markers

SAT0090 Analysis of Potential Risk Factors for Delayed Fracture-Healing

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 622.3-623 ◽  
Author(s):  
S. Fuegener ◽  
P. Hoff ◽  
A. Lang ◽  
T. Gaber ◽  
A. Rakow ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fracture Healing ◽  
Potential Risk ◽  
Delayed Fracture ◽  
Potential Risk Factors ◽  
Delayed Fracture Healing

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chronic Inflammation ◽  
Ex Vivo ◽  
Human Subjects ◽  
Critical Role ◽  
Atherosclerotic Cardiovascular Disease ◽  
Tnf Α ◽  
Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

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