Immunophenotyping By Cluster Of Differentiation (CD) Markers In Patients With Atopic Dermatitis

10.5580/20f0 ◽  
2006 ◽  
Vol 4 (2) ◽  
2021 ◽  
pp. 57-64
Author(s):  
Jung Eun Kim ◽  
Kyung Jae Lee

Biologics, such as tumor necrosis factor-α and interleukin inhibitors, are commonly used for treating immunological skin diseases, including psoriasis, psoriatic arthritis, and atopic dermatitis. The cluster of differentiation inhibitors and immune checkpoint inhibitors has also been used for treating bullous disorders and melanoma, respectively. Other small-molecule inhibitors, such as JAK inhibitors, have been introduced for treating atopic dermatitis and alopecia areata. Hence, given the importance of cytokines and small molecules in antifungal immunity, using these new treatments are proposed to increase the risk of fungal infections. Thus, this review presents an overview of the reported incidences and possible mechanisms of fungal infections related to the use of biologics, including small-molecule inhibitors used for dermatological treatments.


2019 ◽  
Author(s):  
Habib Haybar ◽  
Masumeh Maleki Behzad ◽  
Saeid Shahrabi ◽  
Narges Ansari ◽  
Najmaldin Saki

Abstract Background Cardiovascular diseases (CVDs) are a major cause of mortality worldwide. The results of various studies have shown that abnormality in the frequency and function of blood cells can be involved in CVD complications. In this review, we have focused on abnormalities in the expression of the CD (cluster of differentiation) markers of blood cells to assess the association of these abnormalities with CVD prognosis. Methods We identified the relevant literature through a PubMed search (1990–2018) of English-language articles using the terms “Cardiovascular diseases”, “CD markers”, “leukocytes”, “platelets”, and “endothelial cells”. Results There is a variety of mechanisms for the effect of CD-marker expressions on CVDs prognosis, ranging from proinflammatory processes to dysfunctional effects in blood cells. Conclusion Considering the possible effects of CD-marker expression on CVDs prognosis, particularly prognosis of acute myocardial infarction and atherosclerosis, long-term studies in large cohorts are required to identify the prognostic value of CD markers and to target them with appropriate therapeutic agents.


2018 ◽  
Vol 118 ◽  
pp. 199-246 ◽  
Author(s):  
Harry D. Dawson ◽  
Joan K. Lunney

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