scholarly journals A Single-Institution Retrospective Study of Patients Treated With Laser-Interstitial Thermal Therapy for Radiation Necrosis of the Brain

Cureus ◽  
2021 ◽  
Author(s):  
Claire M Lanier ◽  
Michael Lecompte ◽  
Chase Glenn ◽  
Ryan T Hughes ◽  
Scott Isom ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Radiation Necrosis ◽  
Thermal Therapy ◽  
Single Institution ◽  
Laser Interstitial Thermal Therapy ◽  
The Brain

scholarly journals SURG-06. LASER INTERSTITIAL THERMAL THERAPY COMPARED TO CRANIOTOMY FOR TREATMENT OF RADIATION NECROSIS OR RECURRENT TUMOR IN BRAIN METASTASES FAILING RADIOSURGERY

2019 ◽  
Vol 1 (Supplement_1) ◽  
pp. i31-i32
Author(s):  
Christopher Hong ◽  
Di Deng ◽  
Nanthiya Sujijantarat ◽  
Alberto Vera ◽  
Veronica Chiang
Keyword(s):  
Brain Metastases ◽  
Radiation Necrosis ◽  
Symptom Relief ◽  
Group Analysis ◽  
Progression Free Survival ◽  
Thermal Therapy ◽  
Recurrent Tumor ◽  
Laser Interstitial Thermal Therapy ◽  
Neurological Outcomes ◽  
Significant Difference

Abstract Many publications report laser-interstitial thermal therapy (LITT) as a viable alternative treatment to craniotomy for radiation necrosis (RN) and re-growing tumor occurring after stereotactic radiosurgery (SRS) for brain metastases. No studies to-date have compared the two options. The aim of this study was to retrospectively compare outcomes after LITT versus craniotomy for regrowing lesions in patients previously treated with SRS for brain metastases. Data were collected from a single-institution chart review of patients treated with LITT or craniotomy for previously irradiated brain metastasis. Of 75 patients, 42 had recurrent tumor (56%) and 33 (44%) had RN. Of patients with tumor, 26 underwent craniotomy and 16 LITT. For RN, 15 had craniotomy and 18 LITT. There was no significant difference between LITT and craniotomy in ability to taper off steroids or neurological outcomes. Progression-free survival (PFS) and overall survival (OS) were similar for LITT versus craniotomy, respectively: %PFS-survival at 1-year = 72.2% versus 61.1%, %PFS-survival at 2-years = 60.0% versus 61.1%, p = 0.72; %OS-survival at 1-year = 69.0% versus 69.3%, %OS-survival at 2-years = 56.6% versus 49.5%, p = 0.90. This finding persisted on sub-analysis of smaller lesions under < 3cm in diameter. Craniotomy resulted in higher rates of pre-operative deficit improvement than LITT (p < 0.01). On sub-group analysis, the single factor most significantly associated with OS and PFS was pathology of the lesion. About 40% of tumor lesions needed post-operative salvage with radiation after both craniotomy and LITT. LITT was as efficacious as craniotomy in achieving local control of recurrent irradiated brain metastases and facilitating steroid taper, regardless of pathology. Craniotomy appears to be more advantageous for providing symptom relief in those with pre-operative symptoms.

Laser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases

2020 ◽  
Vol 148 (3) ◽  
pp. 641-649 ◽  
Author(s):  
Nanthiya Sujijantarat ◽  
Christopher S. Hong ◽  
Kent A. Owusu ◽  
Aladine A. Elsamadicy ◽  
Joseph P. Antonios ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Radiation Necrosis ◽  
Thermal Therapy ◽  
Laser Interstitial Thermal Therapy

scholarly journals Laser Interstitial Thermal Therapy for Focal Cerebral Radiation Necrosis: A Case Report and Literature Review

2012 ◽  
Vol 90 (3) ◽  
pp. 192-200 ◽  
Author(s):  
Gazanfar Rahmathulla ◽  
Pablo F. Recinos ◽  
Jose E. Valerio ◽  
Sam Chao ◽  
Gene H. Barnett
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Radiation Necrosis ◽  
Thermal Therapy ◽  
Laser Interstitial Thermal Therapy ◽  
Cerebral Radiation Necrosis

Laser interstitial thermal therapy in the management of brain metastasis and radiation necrosis after radiosurgery: An overview

2016 ◽  
Vol 16 (2) ◽  
pp. 223-232 ◽  
Author(s):  
Mayur Sharma ◽  
Suresh Balasubramanian ◽  
Danilo Silva ◽  
Gene H. Barnett ◽  
Alireza M. Mohammadi
Keyword(s):  
Brain Metastasis ◽  
Radiation Necrosis ◽  
Thermal Therapy ◽  
Laser Interstitial Thermal Therapy

scholarly journals SURG-01. LITT FOR IN-FIELD RECURRENCE OF BRAIN METASTASIS AFTER STEREOTACTIC RADIOSURGERY: OUTCOMES AND MECHANISMS OF DEATH

2019 ◽  
Vol 1 (Supplement_1) ◽  
pp. i30-i31
Author(s):  
Shabbar Danish ◽  
Joel Kaye
Keyword(s):  
Brain Metastasis ◽  
Stereotactic Radiosurgery ◽  
Cancer Patients ◽  
Radiation Necrosis ◽  
Systemic Disease ◽  
Thermal Therapy ◽  
Single Institution ◽  
Future Studies ◽  
The Status ◽  
Intracranial Metastatic Disease

Abstract INTRODUCTION: Brain metastasis (BM) affects up to one-third of adults with cancer and carries a historically bleak prognosis. Thanks to advances in stereotactic radiosurgery (SRS), patients can live longer, and fewer succumb to their intracranial disease. However, rates of in-field recurrence after SRS range from 10–25%, either as true tumor re-growth or radiation necrosis (RN). In this setting, repeat SRS is not recommended and craniotomy may not be feasible or desired by the patient. Laser interstitial thermal therapy (LITT) is an emerging option with promising outcomes. In this study, we investigated outcomes and determined the mechanisms of death among patients with BM who underwent LITT for in-field recurrence after SRS. METHODS: Single institution retrospective review of patients with BM who underwent LITT for in-field recurrence after SRS. RESULTS: Between 2010–2018, seventy (70) patients with BM underwent LITT for in-field recurrence after SRS. At the time of review, 51/70 (72.9%) patients died, 16/70 (22.9%) were alive, and the status of 3/70 (4.3%) was undetermined. Among those who died, death was neurologic in 17/51 (33.3%), non-neurologic in 21/51 (41.2%), and undetermined in 13/51 (25.5%). Median survival after LITT for patients who died from neurologic and non-neurologic causes were 8.9 and 14.3 months, respectively. Mechanisms of neurologic death included progressive intracranial metastatic disease in eight patients and progressive RN in two. Mechanisms of non-neurologic death were nearly all related to progression of primary or systemic disease. CONCLUSIONS: For patients with BM who develop in-field recurrence after SRS, LITT is a viable alternative to craniotomy and can attenuate the neurological burden of this devastating disease. Among our patient population, very few died as the result of intracranial progression. Future studies that investigate which factors predispose patients to intracranial progression despite LITT will further improve its efficacy and ultimately improve the lives of cancer patients.

scholarly journals Laser interstitial thermal therapy for an eloquent region supratentorial brain lesion

2018 ◽  
Vol 44 (videosuppl2) ◽  
pp. V4 ◽  
Author(s):  
Mayur Sharma ◽  
Daria Krivosheya ◽  
Hamid Borghei-Razavi ◽  
Gene H. Barnett ◽  
Alireza M. Mohammadi
Keyword(s):  
Radiation Necrosis ◽  
Brain Lesion ◽  
Thermal Therapy ◽  
Centrum Semiovale ◽  
Laser Interstitial Thermal Therapy ◽  
Corticospinal Tracts ◽  
Stereotactic Technique ◽  
Close Proximity ◽  
Eloquent Area ◽  
History Of

Laser interstitial thermal therapy (LITT) is a minimally invasive stereotactic technique that causes tumor ablation using thermal energy. LITT has shown to be efficacious for the treatment of deep-seated brain lesions, including those near eloquent areas. In this video, the authors present the case of a 62-year-old man with a history of metastatic melanoma who presented with worsening right-sided hemiparesis. MRI revealed a contrast-enhancing lesion in left centrum semiovale in close proximity to corticospinal tracts, consistent with radiation necrosis. The authors review their stepwise technique of LITT with special attention to details for a lesion located near eloquent area.The video can be found here: https://youtu.be/ndrTgi6MXqE.

Radical Laser Interstitial Thermal Therapy Ablation Volumes Increase Progression-Free Survival in Biopsy-Proven Radiation Necrosis

2020 ◽  
Vol 136 ◽  
pp. e646-e659 ◽  
Author(s):  
Evan Luther ◽  
David McCarthy ◽  
Ashish Shah ◽  
Alexa Semonche ◽  
Veronica Borowy ◽  
...  
Keyword(s):  
Radiation Necrosis ◽  
Progression Free Survival ◽  
Thermal Therapy ◽  
Free Survival ◽  
Laser Interstitial Thermal Therapy
Sign in / Sign up

Export Citation Format

Share Document