scholarly journals Laser Interstitial Thermal Therapy for Focal Cerebral Radiation Necrosis: A Case Report and Literature Review

2012 ◽  
Vol 90 (3) ◽  
pp. 192-200 ◽  
Author(s):  
Gazanfar Rahmathulla ◽  
Pablo F. Recinos ◽  
Jose E. Valerio ◽  
Sam Chao ◽  
Gene H. Barnett
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Radiation Necrosis ◽  
Thermal Therapy ◽  
Laser Interstitial Thermal Therapy ◽  
Cerebral Radiation Necrosis

scholarly journals Laser interstitial thermal therapy for treatment of cerebral radiation necrosis

2020 ◽  
Vol 37 (2) ◽  
pp. 68-76 ◽  
Author(s):  
Christopher S. Hong ◽  
Jason M. Beckta ◽  
Adam J. Kundishora ◽  
Aladine A. Elsamadicy ◽  
Veronica L. Chiang
Keyword(s):  
Radiation Necrosis ◽  
Thermal Therapy ◽  
Laser Interstitial Thermal Therapy ◽  
Cerebral Radiation Necrosis

scholarly journals SURG-06. LASER INTERSTITIAL THERMAL THERAPY COMPARED TO CRANIOTOMY FOR TREATMENT OF RADIATION NECROSIS OR RECURRENT TUMOR IN BRAIN METASTASES FAILING RADIOSURGERY

2019 ◽  
Vol 1 (Supplement_1) ◽  
pp. i31-i32
Author(s):  
Christopher Hong ◽  
Di Deng ◽  
Nanthiya Sujijantarat ◽  
Alberto Vera ◽  
Veronica Chiang
Keyword(s):  
Brain Metastases ◽  
Radiation Necrosis ◽  
Symptom Relief ◽  
Group Analysis ◽  
Progression Free Survival ◽  
Thermal Therapy ◽  
Recurrent Tumor ◽  
Laser Interstitial Thermal Therapy ◽  
Neurological Outcomes ◽  
Significant Difference

Abstract Many publications report laser-interstitial thermal therapy (LITT) as a viable alternative treatment to craniotomy for radiation necrosis (RN) and re-growing tumor occurring after stereotactic radiosurgery (SRS) for brain metastases. No studies to-date have compared the two options. The aim of this study was to retrospectively compare outcomes after LITT versus craniotomy for regrowing lesions in patients previously treated with SRS for brain metastases. Data were collected from a single-institution chart review of patients treated with LITT or craniotomy for previously irradiated brain metastasis. Of 75 patients, 42 had recurrent tumor (56%) and 33 (44%) had RN. Of patients with tumor, 26 underwent craniotomy and 16 LITT. For RN, 15 had craniotomy and 18 LITT. There was no significant difference between LITT and craniotomy in ability to taper off steroids or neurological outcomes. Progression-free survival (PFS) and overall survival (OS) were similar for LITT versus craniotomy, respectively: %PFS-survival at 1-year = 72.2% versus 61.1%, %PFS-survival at 2-years = 60.0% versus 61.1%, p = 0.72; %OS-survival at 1-year = 69.0% versus 69.3%, %OS-survival at 2-years = 56.6% versus 49.5%, p = 0.90. This finding persisted on sub-analysis of smaller lesions under < 3cm in diameter. Craniotomy resulted in higher rates of pre-operative deficit improvement than LITT (p < 0.01). On sub-group analysis, the single factor most significantly associated with OS and PFS was pathology of the lesion. About 40% of tumor lesions needed post-operative salvage with radiation after both craniotomy and LITT. LITT was as efficacious as craniotomy in achieving local control of recurrent irradiated brain metastases and facilitating steroid taper, regardless of pathology. Craniotomy appears to be more advantageous for providing symptom relief in those with pre-operative symptoms.

Laser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases

2020 ◽  
Vol 148 (3) ◽  
pp. 641-649 ◽  
Author(s):  
Nanthiya Sujijantarat ◽  
Christopher S. Hong ◽  
Kent A. Owusu ◽  
Aladine A. Elsamadicy ◽  
Joseph P. Antonios ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Radiation Necrosis ◽  
Thermal Therapy ◽  
Laser Interstitial Thermal Therapy

Laser interstitial thermal therapy in the management of brain metastasis and radiation necrosis after radiosurgery: An overview

2016 ◽  
Vol 16 (2) ◽  
pp. 223-232 ◽  
Author(s):  
Mayur Sharma ◽  
Suresh Balasubramanian ◽  
Danilo Silva ◽  
Gene H. Barnett ◽  
Alireza M. Mohammadi
Keyword(s):  
Brain Metastasis ◽  
Radiation Necrosis ◽  
Thermal Therapy ◽  
Laser Interstitial Thermal Therapy
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