scholarly journals Respiratory Failure Following Organophosphate Poisoning: A Literature Review

Cureus ◽  
2017 ◽  
Author(s):  
Pirthvi Raj Giyanwani ◽  
Ujala Zubair ◽  
Osama Salam ◽  
Zarafshan Zubair
Keyword(s):  
Respiratory Failure ◽  
Literature Review ◽  
Organophosphate Poisoning

Central respiratory failure during acute organophosphate poisoning

2013 ◽  
Vol 189 (2) ◽  
pp. 403-410 ◽  
Author(s):  
Jennifer L. Carey ◽  
Courtney Dunn ◽  
Romolo J. Gaspari
Keyword(s):  
Respiratory Failure ◽  
Organophosphate Poisoning

scholarly journals Effect of organophosphorus compounds on the external respiratory function in rats during intratracheal and intraperitoneal administration

2021 ◽  
Author(s):  
Anastasiya A. Kryazhevskikh ◽  
Aleksey A. Kryazhevskikh ◽  
Svetlana N. Subbotina ◽  
Nataliia A. Sklyarova
Keyword(s):  
Respiratory Failure ◽  
Respiratory Function ◽  
Organophosphorus Compounds ◽  
Intraperitoneal Administration ◽  
Toxic Chemicals ◽  
Organophosphate Poisoning ◽  
Toxic Chemical ◽  
Intratracheal Administration ◽  
Chemical Factors ◽  
Lethal Doses

Due to the increasing influence of chemical factors on the human body, the experiment has been conducted using organophosphorus compounds (OPC) to stimulate poisoning cases in the production facilities. Given that the development of respiratory failure is a specific organophosphate poisoning symptom, a comparative analysis of external respiratory function (ERF) in rats with intratracheal and intraperitoneal administration of diisopropyl fluorophosphates (DFP) has been carried out. During the research, the average lethal doses of the toxic chemicals have been established, the conditions of DFP intoxication have been modeled. Thus, LD16 was 0.284 mg/kg by intratracheal administration, 1.6 mg/kg by intraperitoneal administration. Experimental data have shown that the intratracheal intake of OPC causes the development of respiratory failure in the first minutes after poisoning. The return of the ERF indicators to the background values was noted a day after poisoning. With the intraperitoneal administration of the toxic chemical, the rate of development of ERF disorders was lower, toxic effects persisted for two days. The data obtained can be used to make appropriate recommendations for the prevention of accidents and non-emergency cases in a production facility.

Q-T interval prolongation and pleomorphic ventricular tachyarrhythmia (`Torsade de pointes') in organophosphate poisoning: report of a case

1998 ◽  
Vol 17 (10) ◽  
pp. 587-590 ◽  
Author(s):  
Ming-Hsi Wang ◽  
Chuen-Den Tseng ◽  
Shyi-Yann Bair
Keyword(s):  
Respiratory Failure ◽  
Sinus Tachycardia ◽  
Cardiac Toxicity ◽  
Ventricular Tachyarrhythmia ◽  
Torsade De Pointes ◽  
Atropine Sulfate ◽  
Organophosphate Poisoning ◽  
Interval Prolongation ◽  
The Third ◽  
Practicing Physicians

1 A 63-year-old woman presented with drowsy consciousness and dyspnea, followed by respiratory failure, after taking a bottle of parathion for suicide. 2 Sinus tachycardia was noted initially by ECG and Q-T interval prolongation with pleomorphic ventricular tachyarrhythmia (`Torsade de pointes') occurred on the third day of admission. 3 Torsade de pointes was relieved by magnesium sulfate and atropine sulfate intravenously. Q-T interval returned to normal on the fifth day of admission. 4 Practicing physicians should be aware of this uncommon type of cardiac toxicity caused by organophosphate poisoning, Q-T interval prolongation and pleomorphic ventricular tachyarrhythmia.

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