scholarly journals Measurement of Aortic Atherosclerotic Disease Severity: A Novel Tool for Simplified, Objective Disease Scoring Using CT Angiography

Cureus ◽  
2021 ◽  
Author(s):  
Priyanka Reddy ◽  
Madhurima R Chetan ◽  
Charles R Tapping ◽  
Luke Lintin
Keyword(s):  
Disease Severity ◽  
Ct Angiography ◽  
Atherosclerotic Disease ◽  
Disease Scoring

scholarly journals Scoring disease in an animal model of multiple sclerosis using a novel infrared-based automated activity-monitoring system

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Shailesh K. Shahi ◽  
Samantha N. Freedman ◽  
Rachel A. Dahl ◽  
Nitin J. Karandikar ◽  
Ashutosh K. Mangalam
Keyword(s):  
Multiple Sclerosis ◽  
Animal Model ◽  
Disease Severity ◽  
Inverse Correlation ◽  
Therapeutic Agents ◽  
Scoring Methods ◽  
Automated Method ◽  
The Central Nervous System ◽  
Disease Scoring ◽  
Novel Therapeutic

AbstractMultiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system (CNS). Its corresponding animal model, experimental autoimmune encephalomyelitis (EAE), is widely used to understand disease pathogenesis and test novel therapeutic agents. However, existing methods to score EAE disease severity are subjective and often vary between individual researchers, making it difficult to translate findings across different studies. An enhanced automated method of disease scoring would eliminate subjectivity and reduce operator-dependent errors. Here, we used an Infra-Red Activity Monitoring System (IRAMS) to measure murine locomotor activity as a surrogate measure of disease severity and compared it to standard EAE scoring methods. In mice immunized with CNS-specific myelin antigens, we observed an inverse correlation between disease severity and mouse activity, with the IRAMS showing enhanced disease scoring compared to standard EAE scoring methods. Relative to standard EAE scoring methods, IRAMS showed comparable measurement of disease relapses and remissions in the SJL/J-relapsing-remitting model of EAE, and could comparably assess the therapeutic efficiency of the MS drug, Copaxone (Glatiramer acetate-GA). Thus, the IRAMS is a method to measure disease severity in EAE without subjective bias and is a tool to consistently assess the efficacy of novel therapeutic agents for MS.

scholarly journals CT angiography using dual source 64-MSCT versus catheter angiography in assessment of coronary atherosclerotic disease

2012 ◽  
Vol 43 (2) ◽  
pp. 147-155
Author(s):  
Maged A. Hegazy Shouker ◽  
Mohammad A. Yusuf El-Shazely ◽  
Mohamed Abd El-Aziz M. Farag ◽  
Mahmoud F. Samak
Keyword(s):  
Ct Angiography ◽  
Atherosclerotic Disease ◽  
Catheter Angiography ◽  
Dual Source

scholarly journals Association of pericardial fat volume with coronary atherosclerotic disease assessed by CT angiography

2014 ◽  
Vol 87 (1038) ◽  
pp. 20130713 ◽  
Author(s):  
H Nafakhi ◽  
A Al-Mosawi ◽  
H Al-Nafakh ◽  
N Tawfeeq
Keyword(s):  
Ct Angiography ◽  
Atherosclerotic Disease ◽  
Pericardial Fat ◽  
Fat Volume

scholarly journals Evaluation of Cross-Sectional Luminal Morphology in Carotid Atherosclerotic Disease by Use of Spiral CT Angiography

Stroke ◽  
2001 ◽  
Vol 32 (11) ◽  
pp. 2511-2515 ◽  
Author(s):  
C. Porsche ◽  
L. Walker ◽  
D. Mendelow ◽  
D. Birchall
Keyword(s):  
Ct Angiography ◽  
Spiral Ct ◽  
Atherosclerotic Disease ◽  
Cross Sectional ◽  
Spiral Ct Angiography

scholarly journals How Accurate Is CT Angiography in Evaluating Intracranial Atherosclerotic Disease?

Stroke ◽  
2008 ◽  
Vol 39 (4) ◽  
pp. 1184-1188 ◽  
Author(s):  
Mai N. Nguyen-Huynh ◽  
Max Wintermark ◽  
Joey English ◽  
Jack Lam ◽  
Eric Vittinghoff ◽  
...  
Keyword(s):  
Ct Angiography ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease

scholarly journals Granzyme B in Atherosclerosis and Transplant Vascular Disease: Association with Cell Death and Atherosclerotic Disease Severity

2003 ◽  
Vol 16 (5) ◽  
pp. 460-470 ◽  
Author(s):  
Jonathan C. Choy ◽  
Paul C. McDonald ◽  
Agripina C. Suarez ◽  
Vivian H. Y. Hung ◽  
Janet E. Wilson ◽  
...  
Keyword(s):  
Cell Death ◽  
Vascular Disease ◽  
Disease Severity ◽  
Granzyme B ◽  
Disease Association ◽  
Atherosclerotic Disease
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