scholarly journals Association of pericardial fat volume with coronary atherosclerotic disease assessed by CT angiography

2014 ◽  
Vol 87 (1038) ◽  
pp. 20130713 ◽  
Author(s):  
H Nafakhi ◽  
A Al-Mosawi ◽  
H Al-Nafakh ◽  
N Tawfeeq
Keyword(s):  
Ct Angiography ◽  
Atherosclerotic Disease ◽  
Pericardial Fat ◽  
Fat Volume

Digit ratio and hair color relationships with coronary atherosclerotic markers

2019 ◽  
Vol 27 (5) ◽  
pp. 362-368
Author(s):  
Hussein Nafakhi ◽  
Abdulameer A Al-Mosawi ◽  
Mundher M Mudhafar ◽  
Hasan A Al-Nafakh ◽  
Rana Alsaady
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Coronary Plaque ◽  
White Hair ◽  
Digit Ratio ◽  
Hair Color ◽  
Pericardial Fat ◽  
Fourth Digit ◽  
Fat Volume ◽  
Pure White

Objective We aimed to investigate the association between body phenotype markers and coronary atherosclerosis markers. Methods Eighty-nine patients (mean age 57 ± 9 years, 50.5% male) who were assessed for coronary artery disease by 64-slice multidetector computed tomography angiography were enrolled in the study. Results A significant positive association was observed between coronary artery calcification and the second to fourth digit ratio ( r = 0.2, p = 0.00); more notably in males compared to females ( p = 0.03 vs. p = 0.08). There was a significant association between coronary artery calcification and pure white hair ( p = 0.00). There was no significant association between pericardial fat volume and second to fourth digit ratio ( p = 0.8). Pericardial fat volume was significantly associated with pure white hair ( p = 0.02). A significant association was observed between coronary plaque and a higher second to fourth digit ratio ( p = 0.01) and this was more notable in males ( p = 0.04). A significant association was observed between pure white hair and coronary plaque ( p = 0.00). After adjustment for conventional cardiac risk factors, the association of coronary artery calcification and coronary plaque with the second to fourth digit ratio did not persist, whereas the association of pericardial fat volume and coronary artery calcification with pure white hair remained significant ( p = 0.01 and p = 0.00, respectively). Conclusion These results suggest a possible predictive value of hair color, rather than digit ratio, in assessing increased risk of coronary atherosclerosis and cardiac fat deposition.

Sex-Related Differences in the Association of BMI and Pericardial Fat Volume With Coronary Atherosclerotic Markers in Young

Angiology ◽  
2020 ◽  
pp. 000331972097423
Author(s):  
Hussein Nafakhi ◽  
Abdulameer A. Al-Mosawi ◽  
Karrar al-Buthabhak
Keyword(s):  
Coronary Artery ◽  
Young Patients ◽  
Young Male ◽  
Calcium Score ◽  
Coronary Plaque ◽  
Pericardial Fat ◽  
Calcified Plaque ◽  
Luminal Stenosis ◽  
Independent Association ◽  
Fat Volume

We assessed sex-related differences in the association of pericardial fat volume (PFV) and obesity measured by body mass index (BMI) with coronary atherosclerotic markers (coronary artery calcium score [CAC], coronary luminal stenosis severity, and coronary plaque) in young patients. Patients (n = 174; age <50 years) with suspected coronary artery disease who underwent 64-slice multidetector computed tomography angiography were enrolled. Females tended to have a younger age and increased BMI, normal coronary arteries (free from luminal stenosis), and increased percentage of absent coronary plaque compared with males. There was a significant independent association between PFV with coronary luminal stenosis and between PFV and BMI with coronary noncalcified plaque presence after adjustment for conventional cardiac risk factors. On the other hand, males showed a more increment in PFV, CAC, percentage of calcified plaque, and percentage of significant coronary luminal stenosis compared with females. There was a significant independent association of PFV with CAC, significant coronary stenosis, and calcified plaque presence, while no association was observed between BMI with coronary markers in young males. In conclusion, PFV, but not BMI, showed a significant independent association with advanced coronary atherosclerosis in young male patients.

scholarly journals Increased Pericardial Fat Volume Measured From Noncontrast CT Predicts Myocardial Ischemia by SPECT

2010 ◽  
Vol 3 (11) ◽  
pp. 1104-1112 ◽  
Author(s):  
Balaji Tamarappoo ◽  
Damini Dey ◽  
Haim Shmilovich ◽  
Ryo Nakazato ◽  
Heidi Gransar ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Pericardial Fat ◽  
Noncontrast Ct ◽  
Fat Volume

scholarly journals Silent Ischemic Heart Disease and Pericardial Fat Volume in HIV-Infected Patients: A Case-Control Myocardial Perfusion Scintigraphy Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72066 ◽  
Author(s):  
Ulrik S. Kristoffersen ◽  
Anne-Mette Lebech ◽  
Niels Wiinberg ◽  
Claus L. Petersen ◽  
Philip Hasbak ◽  
...  
Keyword(s):  
Heart Disease ◽  
Myocardial Perfusion ◽  
Ischemic Heart Disease ◽  
Myocardial Perfusion Scintigraphy ◽  
Case Control ◽  
Ischemic Heart ◽  
Perfusion Scintigraphy ◽  
Pericardial Fat ◽  
Fat Volume

Abstract 19: Pericardial Fat Volume is Associated with Incident Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis and the Jackson Heart Study

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Susan R Heckbert ◽  
Kerri L Wiggins ◽  
Chad Blackshear ◽  
Benjamin F Banahan ◽  
Yi Yang ◽  
...  
Keyword(s):  
Ethnic Groups ◽  
Cox Regression ◽  
Renin Angiotensin System ◽  
Fee For Service ◽  
Pericardial Fat ◽  
Adjusted Risk ◽  
Race Ethnicity ◽  
Underlying Mechanisms ◽  
Fat Volume

Introduction: Obesity is associated with higher risk of incident AF, but the underlying mechanisms are not well understood. Increased pericardial fat deposition may lead to atrial fibrosis and renin-angiotensin system activation due to free diffusion of cytokines into the thin atrial wall, promoting AF development. Little is known about the association of pericardial fat volume with incident AF. Hypothesis: We assessed the hypothesis that greater pericardial fat volume is associated with higher AF risk in MESA and JHS, overall and in four race/ethnic groups. Methods: Pericardial fat volume was measured on chest CT scans (performed 2000-02 in MESA, 2007-09 in JHS) in 18 2.5-mm slices, from 1.5 cm above to 3.0 cm below the superior extent of the left main coronary artery, using Volume Analysis software (GE Healthcare, Waukesha, WI). Data were combined across the 2 studies. Participants with prevalent AF before the scan were excluded. Incident AF was identified by hospital discharge diagnosis codes for AF or atrial flutter, by study ECG at a follow-up visit, or, for those enrolled in fee-for-service Medicare, by an inpatient or outpatient claim with an AF diagnosis in any position. We used Cox regression to estimate adjusted hazard ratios for incident AF. Results: A total of 8056 participants (6681 in MESA; 1375 in JHS) had pericardial fat volume measured and were followed for clinical events. Among MESA participants, 1855 were AA, 2568 white, 1470 Hispanic, and 788 Chinese; all JHS participants were AA. In the combined data, the average age was 62 years; 55% were women. Greater pericardial fat volume was associated with male sex, older age, white or Hispanic race/ethnicity, greater BMI and systolic blood pressure (SBP), treated hypertension (HTN), impaired fasting glucose, and diabetes mellitus. Despite more obesity, AA participants had on average the lowest pericardial fat volume. During an average of 9 years of follow-up in MESA and 4 years in JHS, a total of 614 cases of incident AF were identified. Whites had the highest unadjusted AF incidence and AA the lowest. In all 4 race/ethnic groups, pericardial fat volume was positively associated with unadjusted AF incidence. After adjustment for age, sex, race/ethnicity, and study, greater pericardial fat volume was associated with higher risk of incident AF (HR=1.17 per SD pericardial fat volume [41 ml], 95% CI 1.09-1.26). After further adjustment for BMI, height, diabetes, SBP, and treated HTN, the association was attenuated (HR 1.06 per SD, 95% CI 0.97-1.16). Associations did not differ in subgroups defined by sex, race/ethnicity, or study. Conclusion: Greater deposition of fat in the pericardium is associated with higher AF incidence and higher adjusted risk of incident AF. Much of this association appears to be related to obesity, diabetes, and HTN. Lower average pericardial fat volume may explain in part the observed lower AF incidence in AA than in whites.

scholarly journals Pericardial fat volume and coronary atherosclerotic markers among body mass index groups

2020 ◽  
Vol 43 (9) ◽  
pp. 993-998
Author(s):  
Mohammed Bader Hassan ◽  
Hussein Nafakhi ◽  
Abdulameer A. Al‐Mosawi
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Pericardial Fat ◽  
Fat Volume

scholarly journals CT angiography using dual source 64-MSCT versus catheter angiography in assessment of coronary atherosclerotic disease

2012 ◽  
Vol 43 (2) ◽  
pp. 147-155
Author(s):  
Maged A. Hegazy Shouker ◽  
Mohammad A. Yusuf El-Shazely ◽  
Mohamed Abd El-Aziz M. Farag ◽  
Mahmoud F. Samak
Keyword(s):  
Ct Angiography ◽  
Atherosclerotic Disease ◽  
Catheter Angiography ◽  
Dual Source
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