scholarly journals Primary Bilateral High-Grade Vesicoureteral Reflux in Children: Management Perspective

Cureus ◽  
2020 ◽  
Author(s):  
Wadha Al Qahtani ◽  
Osama Sarhan ◽  
Abdulhakim Al Otay ◽  
Ahmed El Helaly ◽  
Fouad Al Kawai
2018 ◽  
Vol 17 (2) ◽  
pp. e1192 ◽  
Author(s):  
O. Sarhan ◽  
M. Al Ghanbar ◽  
A. El Helaly ◽  
A. Al Otay ◽  
Z. Nakshabandi

2007 ◽  
Vol 177 (1) ◽  
pp. 325-330 ◽  
Author(s):  
U. Sillén ◽  
G. Holmdahl ◽  
A.L. Hellström ◽  
S. Sjöström ◽  
E. Sölsnes

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Mary Wang ◽  
Yi Li ◽  
Rachel Selekman ◽  
Thomas Gaither ◽  
Laurence Baskin

2018 ◽  
Vol 108 (4) ◽  
pp. 751-756 ◽  
Author(s):  
Sofia Visuri ◽  
Timo Jahnukainen ◽  
Reetta Kivisaari ◽  
Seppo Taskinen

2020 ◽  
Vol 14 (8) ◽  
pp. 683-696
Author(s):  
Flávia C Valério ◽  
Renata D Lemos ◽  
Ana L de C Reis ◽  
Letícia P Pimenta ◽  
Érica LM Vieira ◽  
...  

Aim: This article aimed to review the role of cytokines, chemokines, growth factors and cellular adhesion molecules as biomarkers for vesicoureteral reflux (VUR) and reflux nephropathy (RN). Methods: We reviewed articles from 1979 onward by searching PubMed and Scopus utilizing the combination of words: ‘VUR’ or ‘RN’ and each one of the biomarkers. Results: Genetic, inflammatory, fibrogenic, environmental and epigenetic factors responsible for renal scarring need to be better understood. TGF-β, IL-10, IL-6, IL-8 and TNF seem to exert a role in VUR particularly in RN based on the current literature. Serum levels of procalcitonin have been also associated with high-grade VUR and RN. These molecules should be more intensively evaluated as potential biomarkers for renal scarring in VUR. Conclusion: Further studies are necessary to define which molecules will really be of utility in clinical decisions and as therapeutic targets for VUR and RN.


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