Treatment of Bladder Dysfunction and High Grade Vesicoureteral Reflux Does Not Influence the Spontaneous Resolution Rate

2007 ◽  
Vol 177 (1) ◽  
pp. 325-330 ◽  
Author(s):  
U. Sillén ◽  
G. Holmdahl ◽  
A.L. Hellström ◽  
S. Sjöström ◽  
E. Sölsnes
2008 ◽  
Vol 2008 ◽  
pp. 1-8 ◽  
Author(s):  
Ulla Sillén

In this overview the influence of functional bladder disturbances and of its treatment on the resolution of vesicoureteral reflux (VUR) in children is discussed. Historically both bladder dysfunction entities, the overactive bladder (OAB) and the dysfunctional voiding (DV), have been described in conjunction with VUR. Treatment of the dysfunction was also considered to influence spontaneous resolution in a positive way. During the last decades, however, papers have been published which could not support these results. Regarding the OAB, a prospective study with treatment of the bladder overactivity with anticholinergics, did not influence spontaneous resolution rate in children with a dysfunction including also the voiding phase, DV and DES (dysfunctional elimination syndrome), most studies indicate a negative influence on the resolution rate of VUR in children, both before and after the age for bladder control, both with and without treatment. However, a couple of uncontrolled studies indicate that there is a high short-term resolution rate after treatment with flow biofeedback. It should be emphasized that the voiding phase dysfunctions (DV and DES) are more severe than the genuine filling phase dysfunction (OAB), with an increased frequency of UTI and renal damage in the former groups. To be able to answer the question if treatment of bladder dysfunction influence the resolution rate of VUR in children, randomized controlled studies must be performed.


F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 1552 ◽  
Author(s):  
Michael L. Garcia-Roig ◽  
Andrew J. Kirsch

Vesicoureteral reflux (VUR) is the most common underlying etiology responsible for febrile urinary tract infections (UTIs) or pyelonephritis in children. Along with the morbidity of pyelonephritis, long-term sequelae of recurrent renal infections include renal scarring, proteinuria, and hypertension. Treatment is directed toward the prevention of recurrent infection through use of continuous antibiotic prophylaxis during a period of observation for spontaneous resolution or by surgical correction. In children, bowel and bladder dysfunction (BBD) plays a significant role in the occurrence of UTI and the rate of VUR resolution. Effective treatment of BBD leads to higher rates of spontaneous resolution and decreased risk of UTI.


2004 ◽  
Vol 172 (2) ◽  
pp. 694-699 ◽  
Author(s):  
SOFIA SJÖ STRÖ M ◽  
ULLA SILLÉ N ◽  
MARC BACHELARD ◽  
SVERKER HANSSON ◽  
EIRA STOKLAND

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