Effect of Serum Vitamin D Levels on Cellular Immunity and Antiviral Effects in Chronic Hepatitis B Patients

2016 ◽  
Vol 62 (10/2016) ◽  
Author(s):  
Li-Jie He ◽  
He-Ping Zhang ◽  
Hong-Juan Li ◽  
Jing Wang ◽  
Dan-Dan Chang
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Cellular Immunity ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Antiviral Effects ◽  
Vitamin D Levels

Serum Vitamin D Levels in Chronic Hepatitis B Patients Before and During Treatment

2019 ◽  
Vol 19 ◽  
Author(s):  
Amal Ahmed Mohamed ◽  
Sabry Abdo ◽  
Ebada Said ◽  
Waleed El Agawy ◽  
Peter Awad ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Antiviral Therapy ◽  
Chronic Hepatitis B ◽  
Antiviral Treatment ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Impact

Background & Aims: Hepatitis B is a potentially life-threatening liver infection and it is a major global health problem. Over the past decade, numerous studies have reported that patients with CLD, especially HCV-positive and HBV-positive patients, have decreased 25(OH) D levels. The current study was designed to assess the serum levels of vitamin D [25(OH) D3] in chronic hepatitis B patients, before and during treatment with antiviral therapy. Methods: It was a prospective study in which 80 subjects were enrolled between December 2017 and June 2018. A total of 50 treatment-naïve chronic HBV patients and 30 healthy subjects were recruited. The studied cases received treatment in the form of Lamivudine 100 mg tablet, once daily. Full routine laboratory investigations, HBV DNA measurement by real time PCR; once before initiation of antiviral treatment and again at least 6 months later, serum vitamin D level [25(OH)D3; assessed twice, once before initiation of antiviral treatment and again at least 6 months later; were done for all the patients enrolled in the study. Results: The studied cases showed a significantly low mean serum Vitamin D level when assessed before treatment (21.6 ± 5.8 ng/ml), compared to the level after 6 ms of treatment (31.1 ± 7.3 ng/ml) that was comparable to that of the control group (33.4 ± 5 ng/ml). Conclusion: The present study highlights the impact of antiviral therapy on vitamin D deficiency in CHB patients, where an effective therapy improves vitamin D levels. Meanwhile it is recommended to study the impact of vitamin D replacement and correction on the disease progression or regression.

scholarly journals Relationships between low serum vitamin D levels and HBV “a” determinant mutations in chronic hepatitis B patients

2016 ◽  
Vol 10 (09) ◽  
pp. 1025-1030 ◽  
Author(s):  
Huijuan Zhu ◽  
Xingxiang Liu ◽  
Yi Ding ◽  
Hui Zhou ◽  
Yiying Wang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Vitamin D Deficiency ◽  
Chronic Hepatitis B ◽  
Serum Vitamin ◽  
Vitamin D Insufficiency ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Low Serum

Introduction: Vitamin D is significantly associated with virus replication in chronic hepatitis B virus (HBV) infection. However, the relationship between low serum vitamin D levels and HBV “a” determinant mutations remains unknown. Methodology: A total of 133 chronically HBV-infected, treatment-naive patients were randomly selected in the present study. Serum vitamin D levels were measured by using liquid chromatography-mass spectrometry. The HBV “a” determinant was amplified, sequenced, and analyzed by nested polymerase chain reaction (PCR). Results: Among 133 patients, 36, 88, and 9 patients had vitamin D deficiency (25(OH)D < 14 ng/mL), vitamin D insufficiency (25(OH)D ≥ 14 and < 30 ng/mL), and normal vitamin D serum levels ((25(OH)D ≥ 30 ng/mL), respectively. As results showed, 36 [11 genotype B HBVs (HBV/B) and 25 genotype C HBVs (HBV/C)] were isolated from the vitamin D-deficient group, 88 (48 HBV/B and 40 HBV/C) from the vitamin D-insufficient group, and 4 HBV/C strains from the normal serum-vitamin D group. Compared to the HBV/B infected patients with vitamin D insufficiency, higher rates of amino acid mutation within “a” determinant were detected in HBV/B-infected, vitamin D-deficient patients. Moreover, the change frequency of M133 was 27.27% in HBV/B infected patients with vitamin D deficiency, which was significantly higher than those in the vitamin D-insufficient group (p = 0.040). Conclusions: Vitamin D deficiency is significantly associated with genotype B HBV “a” determinant mutations.

scholarly journals Serum vitamin D and vitamin-D-binding protein levels in children with chronic hepatitis B

2021 ◽  
Vol 27 (3) ◽  
pp. 255-266
Author(s):  
Cai-Zhi Huang ◽  
Jie Zhang ◽  
Lin Zhang ◽  
Cui-Hua Yu ◽  
Yi Mo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Binding Protein ◽  
Serum Vitamin ◽  
Vitamin D Binding Protein ◽  
Serum Vitamin D ◽  
Protein Levels

Association of baseline vitamin D levels with clinical parameters and treatment outcomes in chronic hepatitis B

2015 ◽  
Vol 63 (5) ◽  
pp. 1086-1092 ◽  
Author(s):  
Henry Lik-Yuen Chan ◽  
Magdy Elkhashab ◽  
Huy Trinh ◽  
Won Young Tak ◽  
Xiaoli Ma ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Treatment Outcomes ◽  
Chronic Hepatitis B ◽  
Clinical Parameters ◽  
Vitamin D Levels

scholarly journals VITAMIN D LEVELS IN PATIENTS WITH CHRONIC HEPATITIS B, CHRONIC HEPATITIS C, AND HEALTH CONTROLS

2019 ◽  
Vol 25 (2) ◽  
pp. 2553-2558
Author(s):  
Biljana Ilkovska ◽  
◽  
Bisera Kotevska-Trifunova ◽  
Sandra Hristovska ◽  
Marina Ivanovska ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis B ◽  
Vitamin D Levels

scholarly journals Is there an association between vitamin D and liver fibrosis in patients with chronic hepatitis C?

2017 ◽  
Vol 54 (1) ◽  
pp. 57-59 ◽  
Author(s):  
Kalinca da Silva OLIVEIRA ◽  
Caroline BUSS ◽  
Cristiane Valle TOVO
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Serum Vitamin ◽  
Inflammatory Activity ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Study Results

ABSTRACT BACKGROUND Vitamin D is known for its immunomodulatory, anti-inflammatory and antifibrotic properties, which are quite relevant in the pathogenesis and treatment of many causes of chronic liver disease. OBJECTIVE This study aimed to evaluate the association between serum vitamin D levels and the histopathological findings in patients with chronic hepatitis C virus infection. METHODS Cross-sectional study composed of patients with chronic hepatitis C. All patients underwent vitamin D 25 dosage and anthropometric data analysis. Liver biopsy was performed in a maximum 36-month period before inclusion in the study. RESULTS Of the 74 patients included in the study, 45 (60.8%) were women, mean age was 57.03±9.24 years, and 63 (85.1%) were white. No association was observed between the serum levels of vitamin D and inflammatory activity (P=0.699) nor with the degree of liver fibrosis (P=0.269). CONCLUSION In this study, no association was observed between vitamin D and inflammatory activity, as well as the degree of liver fibrosis, in patients with chronic hepatitis C.

scholarly journals P34 No effect of tenofovir or entecavir on vitamin D levels in Chronic Hepatitis B mono-infected patients. Single centre 'real life' cohort experience

Gut ◽  
2011 ◽  
Vol 60 (Suppl 2) ◽  
pp. A15-A16
Author(s):  
H.-L. Nguyen ◽  
Carey ◽  
M. A. B. Al-Freah ◽  
D. Joe ◽  
R. Sherwood ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Real Life ◽  
Single Centre ◽  
Vitamin D Levels

scholarly journals Vitamin D levels in patients with chronic hepatitis B

Hepatology ◽  
2014 ◽  
Vol 60 (2) ◽  
pp. 768-768 ◽  
Author(s):  
Cumali Efe ◽  
Tugrul Purnak ◽  
Ersan Ozaslan
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Vitamin D Levels
Sign in / Sign up

Export Citation Format

Share Document