scholarly journals Relationships between low serum vitamin D levels and HBV “a” determinant mutations in chronic hepatitis B patients

2016 ◽  
Vol 10 (09) ◽  
pp. 1025-1030 ◽  
Author(s):  
Huijuan Zhu ◽  
Xingxiang Liu ◽  
Yi Ding ◽  
Hui Zhou ◽  
Yiying Wang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Vitamin D Deficiency ◽  
Chronic Hepatitis B ◽  
Serum Vitamin ◽  
Vitamin D Insufficiency ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Low Serum

Introduction: Vitamin D is significantly associated with virus replication in chronic hepatitis B virus (HBV) infection. However, the relationship between low serum vitamin D levels and HBV “a” determinant mutations remains unknown. Methodology: A total of 133 chronically HBV-infected, treatment-naive patients were randomly selected in the present study. Serum vitamin D levels were measured by using liquid chromatography-mass spectrometry. The HBV “a” determinant was amplified, sequenced, and analyzed by nested polymerase chain reaction (PCR). Results: Among 133 patients, 36, 88, and 9 patients had vitamin D deficiency (25(OH)D < 14 ng/mL), vitamin D insufficiency (25(OH)D ≥ 14 and < 30 ng/mL), and normal vitamin D serum levels ((25(OH)D ≥ 30 ng/mL), respectively. As results showed, 36 [11 genotype B HBVs (HBV/B) and 25 genotype C HBVs (HBV/C)] were isolated from the vitamin D-deficient group, 88 (48 HBV/B and 40 HBV/C) from the vitamin D-insufficient group, and 4 HBV/C strains from the normal serum-vitamin D group. Compared to the HBV/B infected patients with vitamin D insufficiency, higher rates of amino acid mutation within “a” determinant were detected in HBV/B-infected, vitamin D-deficient patients. Moreover, the change frequency of M133 was 27.27% in HBV/B infected patients with vitamin D deficiency, which was significantly higher than those in the vitamin D-insufficient group (p = 0.040). Conclusions: Vitamin D deficiency is significantly associated with genotype B HBV “a” determinant mutations.

Serum Vitamin D Levels in Chronic Hepatitis B Patients Before and During Treatment

2019 ◽  
Vol 19 ◽  
Author(s):  
Amal Ahmed Mohamed ◽  
Sabry Abdo ◽  
Ebada Said ◽  
Waleed El Agawy ◽  
Peter Awad ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Antiviral Therapy ◽  
Chronic Hepatitis B ◽  
Antiviral Treatment ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Impact

Background & Aims: Hepatitis B is a potentially life-threatening liver infection and it is a major global health problem. Over the past decade, numerous studies have reported that patients with CLD, especially HCV-positive and HBV-positive patients, have decreased 25(OH) D levels. The current study was designed to assess the serum levels of vitamin D [25(OH) D3] in chronic hepatitis B patients, before and during treatment with antiviral therapy. Methods: It was a prospective study in which 80 subjects were enrolled between December 2017 and June 2018. A total of 50 treatment-naïve chronic HBV patients and 30 healthy subjects were recruited. The studied cases received treatment in the form of Lamivudine 100 mg tablet, once daily. Full routine laboratory investigations, HBV DNA measurement by real time PCR; once before initiation of antiviral treatment and again at least 6 months later, serum vitamin D level [25(OH)D3; assessed twice, once before initiation of antiviral treatment and again at least 6 months later; were done for all the patients enrolled in the study. Results: The studied cases showed a significantly low mean serum Vitamin D level when assessed before treatment (21.6 ± 5.8 ng/ml), compared to the level after 6 ms of treatment (31.1 ± 7.3 ng/ml) that was comparable to that of the control group (33.4 ± 5 ng/ml). Conclusion: The present study highlights the impact of antiviral therapy on vitamin D deficiency in CHB patients, where an effective therapy improves vitamin D levels. Meanwhile it is recommended to study the impact of vitamin D replacement and correction on the disease progression or regression.

scholarly journals Serum vitamin D and vitamin-D-binding protein levels in children with chronic hepatitis B

2021 ◽  
Vol 27 (3) ◽  
pp. 255-266
Author(s):  
Cai-Zhi Huang ◽  
Jie Zhang ◽  
Lin Zhang ◽  
Cui-Hua Yu ◽  
Yi Mo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Binding Protein ◽  
Serum Vitamin ◽  
Vitamin D Binding Protein ◽  
Serum Vitamin D ◽  
Protein Levels

scholarly journals Prevalence and Treatment of Vitamin D Deficiency in Young Male Russian Soccer Players in Winter

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2405 ◽  
Author(s):  
Bezuglov ◽  
Tikhonova ◽  
Zueva ◽  
Khaitin ◽  
Waśkiewicz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Young Male ◽  
Vitamin D Insufficiency ◽  
Soccer Players ◽  
Football Players ◽  
Duration Of Treatment ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Vitamin D (25(OH)D) insufficiency and deficiency are highly prevalent in adult soccer players and can exceed 80% even in regions with high insolation; however, the treatment of this condition is often complicated. The aim of the present study was to examine the prevalence of vitamin D insufficiency and deficiency in youth Russian soccer players and the efficacy of its treatment. Participants were 131 young male football players (age 15.6 ± 2.4 years). Low vitamin D levels (below 30 ng/mL) were observed in 42.8% of the analyzed participants. These athletes were split in two groups composed of persons with vitamin D deficiency (serum vitamin D below 21 ng/mL) and insufficiency (serum vitamin D in range of 21–29 ng/mL). A dietary supplement of 5000 IU cholecalciferol per day was administered for two months. After the treatment, an average 92% increase in vitamin D concentration was observed (before treatment—19.7 ± 5.4 ng/mL, after treatment—34.7 ± 8.6 ng/mL, p<0.001) and 74% of the post-treatment values were within the reference range (30–60 ng/mL). Serum concentration of vitamin D increased by 200% ± 98% (p<0.001) during the first month of treatment with vitamin D deficiency and insufficiency being successfully treated in 83% of the football players. In summary, the prevalence of vitamin D insufficiency and deficiency was high in young Russian soccer players. Furthermore, it was indicated that the daily usage of cholecalciferol in a dose 5000 IU was an effective and well-tolerated treatment for vitamin D insufficiency. No linear dependency between the duration of treatment and increase in vitamin 25(OH)D concentration was observed.

scholarly journals Assessment of Relationship Between Serum Vitamin D Levels and Metabolic Syndrome Components in Hemodialysis Patients

2021 ◽  
Vol 28 (1) ◽  
pp. E202113
Author(s):  
Sevil Karahan Yılmaz ◽  
Cuma Mertoğlu ◽  
Aylin Ayaz
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Vitamin D Insufficiency ◽  
Hemodialysis Patients ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Aim: This study is aimed to evaluate the relationship between serum vitamin D levels and metabolic syndrome in hemodialysis patients. Materials and Methods: This study was conducted with participation of 80 patients undergoing hemodialysis for more than 6 months three times a week, aged > 18 years. Their height, dry weight, waist circumference were measured. Biochemical parameters such as serum 25-hydroxyvitamin D, lipid profile, and fasting blood glucose were analyzed. Metabolic syndrome was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. Severe vitamin D deficiency, 25 (OH) vitamin D < 5 ng/ml; mild vitamin D deficiency, 25 (OH) vitamin D 5-15 ng/ml; vitamin D insufficiency, 25 (OH) vitamin D 16-30 ng/ml, and vitamin D sufficiency, 25 (OH) vitamin D > 30 ng/ml were categorized. Statistical analysis of the data was performed with the use of SPSS version 21.0. Results: 48.4% of hemodialysis patients were identified to have metabolic syndrome. According to the serum levels of vitamin D; 35.0% of patients had severe vitamin D deficiency, 37.4% of patients had mild vitamin D deficiency, 18.8% of patients had vitamin D insufficiency and 8.8% of patients had vitamin D sufficiency (> 30 ng/ml). Vitamin D insufficiency was significantly associated with metabolic syndrome and central obesity. Conclusions: Deficiency/insufficiency is observed in serum 25-hydroxyvitamin D levels in hemodialysis patients. Vitamin D insufficiency is associated with metabolic syndrome.

scholarly journals Vitamin D Serum Level in Patients with Schizophrenia in West Java, Indonesia

2020 ◽  
pp. 122-127
Author(s):  
Nofan Pratama Maulana ◽  
Tuti Kurnianingsih ◽  
Sumartini Dewi
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Vitamin D Deficiency ◽  
Mental Hospital ◽  
Serum Vitamin ◽  
Vitamin D Insufficiency ◽  
West Java ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Schizophrenic Patients

Background: Vitamin D is an immune-regulator that influences the neuro-inflammation process in schizophrenia. The study aimed to explore the vitamin D serum level in schizophrenic patients at the outpatient clinic of the Provincial Mental Hospital, West Java, Indonesia. Methods: A quantitative descriptive study was conducted in November-December 2019 using secondary data of all-male schizophrenic patients at the Provincial Mental Hospital. Data collected were demographic characteristics, clinical characteristics, and vitamin D Level. Scoring was then performed using Positive and Negative Syndrome Scale (PANSS) and Montreal Cognitive Assessment (MoCA) to assess the positive and negative symptoms as well as the cognitive symptoms based on the serum vitamin D levels. Result: All male schizophrenic patients had a low serum vitamin D level (mean16.67±5.6ng/ml) with 64.52% of them had vitamin D deficiency (<20 ng/ml). Interestingly, patients with vitamin D deficiency had a negative symptom (mean22.1±5.6ng/ml) whereas those with vitamin D insufficiency (20-29 ng/ml) had a positive symptom (mean 18.55±5.6ng/ml). Furthermore, patients with vitamin D deficiency had a lower impaired cognitive function value (mean 19.7±3.4ng/ml) compared to those with vitamin D insufficiency. Conclusions: A low vitamin D serum level in schizophrenic patients may play a role in the pathogenesis of this disorder. Further studies are needed to confirm this finding.

scholarly journals Association Between Low Serum Vitamin D Levels and Sepsis: A Single-Center Study in Tehran, Iran

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Masume Bayat ◽  
Latif Gachkar ◽  
Mahya Zahirnia ◽  
Fahimeh Hadavand
Keyword(s):  
Vitamin D ◽  
Severe Sepsis ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Plasma Concentrations ◽  
Serum Vitamin ◽  
Vitamin D Insufficiency ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: Vitamin D insufficiency is common in critically ill patients. It is hypothesized that vitamin D deficiency would be associated with sepsis in the critically ill. Thus, the present study aimed to investigate the association between vitamin D and sepsis severity. Method: In this cross-sectional study, patients with sepsis referring to a university hospital in Tehran, Iran, from February 2018 to March 2019 were included. Plasma concentrations of vitamin D in critically ill subjects admitted were assessed. Data were analyzed using SPSS version 20.0. P-values less than 0.05 were considered statistically significant. Results: Among the investigated patients, the mean serum level of vitamin D3 was 19.03 ± 13.08 ng/mL. The prevalence of vitamin D insufficiency in critically ill subjects with sepsis was 100% (150/150). Only sex (P = 0.01) indicated a significant association with vitamin D. Patients suffering from severe sepsis had lower levels of vitamin D compared to the patients with non-severe sepsis (P = 0.07). Conclusions: The present study showed that all critically ill patients studied had vitamin D insufficiency. In line with the biological evidence, the present study suggests that vitamin D deficiency may predispose patients to sepsis. Further studies are needed to establish the causes and mechanisms underlying these interpretations.

scholarly journals SERUM VITAMIN D STATUS AMONG CRITICALLY ILL CHILDREN WITH RESPIRATORY INFECTIONS

2020 ◽  
pp. 1-3
Author(s):  
SS Kalyanshettar ◽  
Sanjeevani Umarani ◽  
M M Patil ◽  
SV Patil
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Serum Vitamin ◽  
Respiratory Illness ◽  
Respiratory Support ◽  
Critically Ill Children ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Low Serum

Objective: To know whether low levels of vitamin D affects severity of respiratory illness and its clinical outcomes. Design: Hospital based prospective cross sectional observational study. Setting : Pediatric Intensive Care Unit in Teaching Hospital affiliated with Medical College with study period of one and half years Methodology The study was performed on 50 cases of critically ill children with respiratory infectious disease admitted to the paediatric intensive care unit. Assessment of severity of respiratory infection was done with Paediatric respiratory severity score (PRESS). Serum vitamin D levels were assessed. Duration of PICU stay, hospital stay, need and type of respiratory support and its duration were also recorded. Results: Severe Vitamin D deficiency (<20ng/ml) was noted in 64% of total cases admitted with respiratory illness in PICU. Among these, 62.5% (20) cases had severe respiratory illness. The severity of respiratory illness was found to be highly significant with low Serum vitamin D values (p<0.01). Low serum vitamin D levels were also significantly associated with length of PICU stay (p<0.01), length of hospital stay (p=0.014), type of respiratory support (<0.001) and duration of respiratory support (p<0.001) Conclusion: A high prevalence of Vitamin D deficiency and insufficiency was found in critically ill children admitted with Respiratory infection. A strong statistical correlation was noted with Vitamin D deficiency and strongly associated with prolonged PICU care, respiratory support and hospitalization.

Vitamin D deficiency in minority populations

2014 ◽  
Vol 18 (3) ◽  
pp. 379-391 ◽  
Author(s):  
Glen B Taksler ◽  
David M Cutler ◽  
Edward Giovannucci ◽  
Nancy L Keating
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Sun Exposure ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Minority Populations ◽  
Uv Index ◽  
Serum Vitamin D ◽  
Vitamin D Levels

AbstractObjectiveBlack and Hispanic individuals synthesize less vitamin D per unit of sun exposure than white individuals. The relationship between UV radiation and vitamin D insufficiency in minorities has not been well explored.DesignProspective cohort study.SettingUsing the National Health and Nutrition Examination Survey, we obtained serum vitamin D levels for non-Hispanic Whites, Hispanics and non-Hispanic Blacks aged ≥18 years from 2000–2006. We linked these data with the average monthly solar UV index by census tract and data on sun exposure, vitamin D supplementation, health and demographics. We used multivariable regression analyses to assess vitamin D deficiency (<15 ng/ml) and insufficiency (<20 ng/ml) in January (when the UV index was lowest) by race/ethnicity and geography.SubjectsAdults (n 14 319) aged ≥18 years.ResultsA 1-point increase in the UV index was associated with a 0·51 ng/ml increase in vitamin D (95 % CI 0·35, 0·67 ng/ml; P<0·001). Non-Hispanic Black race and Hispanic ethnicity were associated with a 7·47 and 3·41 ng/ml decrease in vitamin D, respectively (both P<0·001). In January, an estimated 65·4 % of non-Hispanic Blacks were deficient in vitamin D, compared with 28·9 % of Hispanics and 14·0 % of non-Hispanic Whites. An estimated 84·2 % of non-Hispanic Blacks were insufficient in vitamin D v. 56·3 % of Hispanics and 34·8 % of non-Hispanic Whites. More non-Hispanic Blacks were estimated to be deficient in vitamin D in January in the highest UV index quartile than were non-Hispanic Whites in the lowest UV index quartile (60·2 % v. 25·7 %).ConclusionsWintertime vitamin D insufficiency is pervasive among minority populations, and not uncommon among non-Hispanic Whites.

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