scholarly journals Autonomic dysfunction and white matter microstructural changes in drug-naïve patients with Parkinson’s disease

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5539 ◽  
Author(s):  
Amir Ashraf-Ganjouei ◽  
Alireza Majd ◽  
Ali Javinani ◽  
Mohammad Hadi Aarabi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nervous System ◽  
Distribution Function ◽  
White Matter ◽  
Autonomic Dysfunction ◽  
Spin Distribution ◽  
Microstructural Changes ◽  
Spin Distribution Function ◽  
Drug Naïve

Background Autonomic dysfunction (AD) is one of the non-motor features of Parkinson’s disease (PD). Some symptoms tend to occur in the early stages of PD. AD also has a great impact on patient’s quality of life. In this study, we aimed to discover the association between AD (Scales for Outcomes in Parkinson’s disease-Autonomic, SCOPA-AUT) and microstructural changes in white matter tracts in drug-naïve early PD patients to elucidate the central effects of autonomic nervous system impairments. Method In total, this study included 85 subjects with PD recruited from the Parkinson’s Progression Markers Initiative (PPMI) database. Among the 85 PD patients, 38 were in Hoehn & Yahr stage 1 (HY1PD) and 47 were in stage 2 (HY2PD). Diffusion magnetic resonance imaging (DMRI) data were reconstructed in the MNI space using q-space diffeomorphic reconstruction to obtain the spin distribution function. The spin distribution function (SDF) values were used in DMRI connectometry analysis. We investigated through diffusion MRI connectometry the structural correlates of white matter tracts with SCOPA-AUT subscores and total score. Results Connectometry analysis also revealed positive association with white matter density in bilateral corticospinal tract in HY1PD patients and negative association in genu of corpus callosum (CC) and, bilateral cingulum in both groups. In addition, there were associations between gastrointestinal, sexual, thermoregulatory and urinary items and structural brain connectivity in PD. Conclusion Our study reveals positive correlation, suggesting neural compensations in early PD. Cingulum and CC tracts have well-known roles in PD pathology, compatible with our findings that bring new insights to specific areas of AD and its role in central nervous system (CNS) neurodegeneration, paving the way for using prodromal makers in the diagnosis and treatment of PD.

scholarly journals White Matter Tract Alterations in Drug-Naïve Parkinson’s Disease Patients With Impulse Control Disorders

2018 ◽  
Vol 9 ◽  
Author(s):  
Mahtab Mojtahed Zadeh ◽  
Amir Ashraf-Ganjouei ◽  
Farzaneh Ghazi Sherbaf ◽  
Maryam Haghshomar ◽  
Mohammad Hadi Aarabi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Impulse Control ◽  
Impulse Control Disorders ◽  
White Matter Tract ◽  
Drug Naïve

scholarly journals Characterizing white matter alterations in drug-naïve de novo Parkinson’s disease with diffusion MRI

2021 ◽  
Author(s):  
Yiming Xiao ◽  
Terry M. Peters ◽  
Ali R. Khan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
De Novo ◽  
Neurodegenerative Disorder ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Motor Dysfunction ◽  
White Matter Integrity ◽  
Drug Naïve

AbstractParkinson’s disease (PD) is a progressive neurodegenerative disorder that is characterized by a range of motor and non-motor symptoms, often with the motor dysfunction initiated unilaterally. Knowledge regarding disease-related alterations in white matter pathways can effectively help improve the understanding of the disease and propose targeted treatment strategies. Microstructural imaging techniques, including diffusion tensor imaging (DTI), allows inspection of white matter integrity to study the pathogenesis of various neurological conditions. Previous voxel-based analyses with DTI measures, such as fractional anisotropy and mean diffusivity have uncovered changes in brain regions that are associated with PD, but the conclusions were inconsistent, partially due to small patient cohorts and the lack of consideration for clinical laterality onset, particularly in early PD. Fixel-based analysis (FBA) is a recent framework that offers tract-specific insights regarding white matter health, but very few FBA studies on PD exist. We present a study that reveals strengthened and weakened white matter integrity that is subject to symptom laterality in a large drug-naïve de novo PD cohort using complementary DTI and FBA measures. The findings suggest that the disease gives rise to both functional degeneration and the creation of compensatory networks in the early stage.

scholarly journals Differential White Matter Regional Alterations in Motor Subtypes of Early Drug-Naive Parkinson’s Disease Patients

2018 ◽  
Vol 32 (2) ◽  
pp. 129-141 ◽  
Author(s):  
Ming-Ching Wen ◽  
Hannah S. E. Heng ◽  
Zhonghao Lu ◽  
Zheyu Xu ◽  
Ling Ling Chan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Drug Naïve ◽  
Early Drug

scholarly journals Microstructural changes in white matter associated with freezing of gait in Parkinson's disease

2015 ◽  
Vol 30 (4) ◽  
pp. 567-576 ◽  
Author(s):  
Sarah Vercruysse ◽  
Inge Leunissen ◽  
Griet Vervoort ◽  
Wim Vandenberghe ◽  
Stephan Swinnen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Freezing Of Gait ◽  
Microstructural Changes

White matter microstructural changes preceding the development of impulse control disorders in patients with Parkinson's disease

2021 ◽  
Vol 429 ◽  
pp. 119516
Author(s):  
Simone Aloisio ◽  
Rosa De Micco ◽  
Giusy Caiazzo ◽  
Mattia Siciliano ◽  
Federica Di Nardo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Impulse Control ◽  
Impulse Control Disorders ◽  
Microstructural Changes

scholarly journals White Matter Tract Alterations in Drug-Naïve Parkinson's Disease Patients With Excessive Daytime Sleepiness

2019 ◽  
Vol 10 ◽  
Author(s):  
Amir Ashraf-Ganjouei ◽  
Ghazaleh Kheiri ◽  
Maryam Masoudi ◽  
Bahram Mohajer ◽  
Mahtab Mojtahed Zadeh ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
White Matter Tract ◽  
Drug Naïve

Brain pathway differences between Parkinson's disease patients with and without depressive symptoms

2017 ◽  
Vol 41 (S1) ◽  
pp. S349-S349 ◽  
Author(s):  
S. Mohammadi Jooyandeh ◽  
T.C. Baghai ◽  
M.H. Aarabi ◽  
M. Dolatshahi ◽  
B. Langguth
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Depressive Symptoms ◽  
Brain Connectivity ◽  
Neural Basis ◽  
Spin Distribution ◽  
Inferior Longitudinal Fasciculus ◽  
Spin Distribution Function ◽  
Progression Markers ◽  
Competing Interest

IntroductionDepression occurs frequently in patients suffering from Parkinson's disease (PD). However, the neural basis of depression in PD remains unclear. Diffusion magnetic resonance imaging (DMRI) connectometry is based on the spin distribution function (SDF), which quantifies the density of diffusing water.AimThe aim of this study was to assess the microstructural changes in the brain connectivity of PD patients with and without depressive symptoms.MethodsDMRI was used to assess microstructural abnormalities in the brains of 16 PD patients with depressive symptoms compared to 11 PD patients without depressive symptoms. Data used in the preparation of this paper were obtained from the Parkinson's progression markers initiative (PPMI) database (http://www.ppmi-info.org/data/). This dataset was acquired on a 3-Tesla scanner (Siemens), producing 64 DWI at b = 1000 s/mm2 and one b0 image. Diffusion MRI data were corrected for subject motion, eddy current distortions, and susceptibility artefacts due to magnetic field inhomogeneity. DMRI connectometry was conducted in a total of 27 patients using percentage measurement.ResultsPD Patients with depressive symptoms showed decreased anisotropy (FDR < 0.05) in the fornix bilaterally, left inferior longitudinal fasciculus (ILF) and corticospinal tract bilaterally compared to PD patients without depressive symptoms.ConclusionsLesser WM integrity of the left ILF fibers, which connect visual face recognition areas to the amygdala and hippocampus, seems to be associated with depressive symptoms in PD patients. Our study supports the hypothesis that neurodegenerative processes in projections from the somatosensory, cingulate, and insular cortices may be related to depression in PD.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Plasma DNA Mediate Autonomic Dysfunctions and White Matter Injuries in Patients with Parkinson’s Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Meng-Hsiang Chen ◽  
Pei-Chin Chen ◽  
Cheng-Hsien Lu ◽  
Hsiu-Ling Chen ◽  
Yi-Ping Chao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Autonomic Dysfunction ◽  
Baroreflex Sensitivity ◽  
Nuclear Dna ◽  
Mediation Model ◽  
Plasma Dna ◽  
Cardiovascular Autonomic Dysfunction

Background. Cardiovascular autonomic dysfunction is well known in Parkinson’s disease (PD) presentation and it produces hypoperfusion of vital organs. The association between cardiovascular autonomic dysfunction and oxidative stress was examined in previous animal models. Oxidative stress and neuroinflammation were thought to have roles in PD pathogenesis. Owing to the relative low intrinsic antioxidative properties, brain white matter (WM) is vulnerable to the oxidative stress. This study is conducted to examine possible relationships by using a hypothesis-driven mediation model. Methods. Twenty-nine patients with PD and 26 healthy controls participated in this study, with complete examinations of cardiac autonomic parameters, plasma DNA level, and WM integrity. A single-level three-variable mediation model was used to investigate the possible relationships. Results. The elevated serum oxidative stress biomarkers include plasma nuclear DNA and mitochondrial DNA, and poorer cardiac autonomic parameters and multiple regional microstructural WM changes are demonstrated. Further mediation analysis shows that plasma nuclear DNA served as the mediators between poorer baroreflex sensitivity and mean diffusivity changes in cingulum. Conclusions. These results provide a possible pathophysiology for how the poor baroreflex sensitivity and higher oxidative stress adversely impacted the WM integrity. This model could provide us with a piece of the puzzle of the entire PD pathogenesis.

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