scholarly journals Microstructural changes in white matter associated with freezing of gait in Parkinson's disease

2015 ◽  
Vol 30 (4) ◽  
pp. 567-576 ◽  
Author(s):  
Sarah Vercruysse ◽  
Inge Leunissen ◽  
Griet Vervoort ◽  
Wim Vandenberghe ◽  
Stephan Swinnen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Freezing Of Gait ◽  
Microstructural Changes

White matter hyperintensities as a predictor of freezing of gait in Parkinson's disease

2019 ◽  
Vol 66 ◽  
pp. 105-109 ◽  
Author(s):  
Seok Jong Chung ◽  
Yang Hyun Lee ◽  
Han Soo Yoo ◽  
Jungsu S. Oh ◽  
Jae Seung Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Freezing Of Gait

scholarly journals Autonomic dysfunction and white matter microstructural changes in drug-naïve patients with Parkinson’s disease

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5539 ◽  
Author(s):  
Amir Ashraf-Ganjouei ◽  
Alireza Majd ◽  
Ali Javinani ◽  
Mohammad Hadi Aarabi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nervous System ◽  
Distribution Function ◽  
White Matter ◽  
Autonomic Dysfunction ◽  
Spin Distribution ◽  
Microstructural Changes ◽  
Spin Distribution Function ◽  
Drug Naïve

Background Autonomic dysfunction (AD) is one of the non-motor features of Parkinson’s disease (PD). Some symptoms tend to occur in the early stages of PD. AD also has a great impact on patient’s quality of life. In this study, we aimed to discover the association between AD (Scales for Outcomes in Parkinson’s disease-Autonomic, SCOPA-AUT) and microstructural changes in white matter tracts in drug-naïve early PD patients to elucidate the central effects of autonomic nervous system impairments. Method In total, this study included 85 subjects with PD recruited from the Parkinson’s Progression Markers Initiative (PPMI) database. Among the 85 PD patients, 38 were in Hoehn & Yahr stage 1 (HY1PD) and 47 were in stage 2 (HY2PD). Diffusion magnetic resonance imaging (DMRI) data were reconstructed in the MNI space using q-space diffeomorphic reconstruction to obtain the spin distribution function. The spin distribution function (SDF) values were used in DMRI connectometry analysis. We investigated through diffusion MRI connectometry the structural correlates of white matter tracts with SCOPA-AUT subscores and total score. Results Connectometry analysis also revealed positive association with white matter density in bilateral corticospinal tract in HY1PD patients and negative association in genu of corpus callosum (CC) and, bilateral cingulum in both groups. In addition, there were associations between gastrointestinal, sexual, thermoregulatory and urinary items and structural brain connectivity in PD. Conclusion Our study reveals positive correlation, suggesting neural compensations in early PD. Cingulum and CC tracts have well-known roles in PD pathology, compatible with our findings that bring new insights to specific areas of AD and its role in central nervous system (CNS) neurodegeneration, paving the way for using prodromal makers in the diagnosis and treatment of PD.

scholarly journals Amyloid ß Impacts Future Freezing of Gait in Parkinson’s Disease Via White Matter Hyperintensities

2020 ◽  
Author(s):  
Mahsa Dadar ◽  
Janis Miyasaki ◽  
Simon Duchesne ◽  
Richard Camicioli
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Freezing Of Gait ◽  
Amyloid Β ◽  
Common Symptom ◽  
Activity Levels ◽  
Lewy Body Pathology ◽  
The Impact

AbstractBackgroundFreezing of gait (FOG) is a common symptom in Parkinson’s Disease (PD) patients. Previous studies have reported relationships between FOG, substantia nigra (SN) degeneration, dopamine transporter (DAT) concentration, as well as amyloid β deposition. However, there is a paucity of research on the concurrent impact of white matter damage.ObjectivesTo assess the inter-relationships between these different co-morbidities, their impact on future FOG and whether they act independently of each other.MethodsWe used baseline MRI and longitudinal gait data from the Parkinson’s Progression Markers Initiative (PPMI). We used deformation based morphometry (DBM) from T1-weighted MRI to measure SN atrophy, and segmentation of white matter hyperintensities (WMH) as a measure of WM pathological load. Putamen and caudate DAT levels from SPECT as well as cerebrospinal fluid (CSF) amyloid β were obtained directly from the PPMI. Following correlation analyses, we investigated whether WMH burden mediates the impact of amyloid β on future FOG.ResultsSN DBM, WMH load, putamen and caudate DAT activity and CSF amyloid β levels were significantly different between PD patients with and without future FOG (p < 0.008). Mediation analysis demonstrated an effect of CSF amyloid β levels on future FOG via WMH load, independent of SN atrophy and striatal DAT activity levels.ConclusionsAmyloid β might impact future FOG in PD patients through an increase in WMH burden, in a pathway independent of Lewy body pathology.

White matter microstructural changes preceding the development of impulse control disorders in patients with Parkinson's disease

2021 ◽  
Vol 429 ◽  
pp. 119516
Author(s):  
Simone Aloisio ◽  
Rosa De Micco ◽  
Giusy Caiazzo ◽  
Mattia Siciliano ◽  
Federica Di Nardo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Impulse Control ◽  
Impulse Control Disorders ◽  
Microstructural Changes

Freezing of gait in Parkinson’s disease: gray and white matter abnormalities

2017 ◽  
Vol 265 (1) ◽  
pp. 52-62 ◽  
Author(s):  
Sara Pietracupa ◽  
Antonio Suppa ◽  
Neeraj Upadhyay ◽  
Costanza Giannì ◽  
Giovanni Grillea ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Freezing Of Gait ◽  
White Matter Abnormalities

scholarly journals Alterations in white matter network topology contribute to freezing of gait in Parkinson’s disease

2018 ◽  
Vol 265 (6) ◽  
pp. 1353-1364 ◽  
Author(s):  
Julie M. Hall ◽  
James M. Shine ◽  
Kaylena A. Ehgoetz Martens ◽  
Moran Gilat ◽  
Kathryn M. Broadhouse ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Network Topology ◽  
Freezing Of Gait

scholarly journals Relating Response Inhibition, Brain Connectivity, and Freezing of Gait in People with Parkinson’s Disease

2020 ◽  
pp. 1-11
Author(s):  
Daniel S. Peterson ◽  
Katrijn Smulders ◽  
Martina Mancini ◽  
John G. Nutt ◽  
Fay B. Horak ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Response Inhibition ◽  
Structural Integrity ◽  
Right Hemisphere ◽  
Freezing Of Gait ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Microstructural Integrity

ABSTRACT Objective: Freezing of gait (FoG) in Parkinson’s disease (PD) has been associated with response inhibition. However, the relationship between response inhibition, neural dysfunction, and PD remains unclear. We assessed response inhibition and microstructural integrity of brain regions involved in response inhibition [right hemisphere inferior frontal cortex (IFC), bilateral pre-supplementary motor areas (preSMA), and subthalamic nuclei (STN)] in PD subjects with and without FoG and elderly controls. Method: Twenty-one people with PD and FoG (PD-FoG), 18 without FoG (PD-noFoG), and 19 age-matched controls (HC) completed a Stop-Signal Task (SST) and MRI scan. Probabilistic fiber tractography assessed structural integrity (fractional anisotropy, FA) among IFC, preSMA, and STN regions. Results: Stop-signal performance did not differ between PD and HC, nor between PD-FoG and PD-noFoG. Differences in white matter integrity were observed across groups (.001 < p < .064), but were restricted to PD versus HC groups; no differences in FA were observed between PD-FoG and PD-noFoG (p > .096). Interestingly, worse FoG was associated with higher (better) mean FA in the r-preSMA, (β = .547, p = .015). Microstructural integrity of the r-IFC, r-preSMA, and r-STN tracts correlated with stop-signal performance in HC (p ≤ .019), but not people with PD. Conclusion: These results do not support inefficient response inhibition in PD-FoG. Those with PD exhibited white matter loss in the response inhibition network, but this was not associated with FoG, nor with response inhibition deficits, suggesting FoG-specific neural changes may occur outside the response inhibition network. As shown previously, white matter loss was associated with response inhibition in elderly controls, suggesting PD may disturb this relationship.

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