scholarly journals Mindfulness and autonomous sensory meridian response (ASMR)

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5414 ◽  
Author(s):  
Beverley K. Fredborg ◽  
James M. Clark ◽  
Stephen D. Smith
Keyword(s):  
Emotional State ◽  
Matched Control ◽  
Emotional Experiences ◽  
Global Measure ◽  
Mindful Attention ◽  
Distinct Subset ◽  
Audiovisual Stimuli ◽  
Toronto Mindfulness Scale ◽  
Age And Sex ◽  
Perceptual Phenomenon

Background Autonomous sensory meridian response (ASMR) is a perceptual phenomenon in which specific audiovisual stimuli frequently elicit tingling sensations on the scalp and neck. These stimuli (“ASMR triggers”) are typically social in nature (e.g., watching someone brush their hair, hearing whispering,) and often elicit a calm and positive emotional state that may last up to several minutes. ASMR experiences phenomenologically overlap with mindfulness; however, no research has directly examined how mindfulness might relate to ASMR. Methods In the current study, 284 individuals with ASMR completed the Toronto Mindfulness Scale (TMS), the Mindful Attention and Awareness Scale (MAAS), and a questionnaire examining ASMR experiences. Age- and sex-matched control participants were asked to view two ASMR-eliciting videos to ensure that they did not experience tingling sensations associated with ASMR; they then completed the TMS and MAAS questionnaires. Results When compared with matched controls, individuals with ASMR generated significantly higher scores on the MAAS, a global measure of mindfulness, as well as significantly higher scores on the Curiosity subscale of the TMS. Conclusions These results suggest that the sensory-emotional experiences associated with ASMR may be partially explained by a distinct subset of characteristics associated with mindfulness.

scholarly journals Circulating miRNA-202-3p is a potential novel biomarker for diagnosis of type 1 gastric neuroendocrine neoplasms

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dou Dou ◽  
Xiao-kou Li ◽  
Qi-sheng Xia ◽  
Ying-ying Chen ◽  
Yuan-liang Li ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Matched Control ◽  
Future Research ◽  
Control Group ◽  
Neuroendocrine Neoplasms ◽  
Diagnostic Biomarkers ◽  
Standard Curve ◽  
Qrt Pcr ◽  
Age And Sex

Abstract Background Currently, there are no circulating diagnostic biomarkers for gastric neuroendocrine neoplasms (g-NENs). In previous studies, we found that miRNA-202-3p is overexpressed in the tumour tissue of type 1 g-NEN. We speculated that miRNA-202-3p is also likely to be highly expressed in circulating blood. Methods A total of 27 patients with type 1 g-NEN and 27 age- and sex-matched control participants were enrolled in this study. The miRNA-202-3p levels in serum obtained from the participants were measured by qRT‐PCR. The expression level of miRNA-202-3p in the samples was calculated by comparison with a standard curve. Results The clinical characteristics of the patients were similar to those of the patient samples in previous reports. Expression of miRNA-202-3p was significantly higher in the patient group (3.84 × 107 copies/nl) than in the control group (0.635 × 107 copies/nl). The area under the ROC curve (AUC) was 0.878 (95% CI: 0.788–0.968), and the optimal cut-off point was approximately 1.12 × 107 copies/nl. The sensitivity and specificity were 88.9% and 77.8%, respectively. Conclusion This study suggests that miRNA-202-3p is potentially useful as a biomarker of type 1 g-NEN; further investigation and verification should be performed in future research.

Enlargement of cerebrospinal fluid spaces in long-term benzodiazepine abusers

1987 ◽  
Vol 17 (4) ◽  
pp. 869-873 ◽  
Author(s):  
C. Schmauss ◽  
J.-C. Krieg
Keyword(s):  
Low Dose ◽  
Matched Control ◽  
Control Group ◽  
High Dose ◽  
Withdrawal Therapy ◽  
The Mean ◽  
Dose Dependent ◽  
Dose Dependent Effect ◽  
Age And Sex

SynopsisIn 17 benzodiazepine (BDZ) dependent in-patients a CT scan was performed before initiation of withdrawal therapy. The evaluation of the ventricular to brain ratio (VBR) by standardized and computerized measurements revealed significantly higher mean VBRs for both high-and low-dose BDZ-dependent patients compared to the mean VBR of an age- and sex-matched control group. In addition, the mean VBR of high-dose BDZ-dependent patients (N = 8) was significantly higher than the mean VBR of low-dose BDZ-dependent patients (N = 9). This difference could not be accounted for by the age of the patients or duration of BDZ-dependency and, therefore, suggests a dose-dependent effect of BDZs on the enlargement of internal CSF-spaces. On the other hand, higher values for the width of external CSF-spaces were found to be related to increasing age of the patients and duration of BDZ-dependency.

Increased Fraction of Circulating Activated Platelets in Acute and Previous Cerebrovascular Ischemia

1998 ◽  
Vol 80 (08) ◽  
pp. 298-301 ◽  
Author(s):  
Andreas Ruf ◽  
Axel Vogt ◽  
Christoph Lichy ◽  
Florian Buggle ◽  
Heinrich Patscheke ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Phase Contrast ◽  
Matched Control ◽  
Shape Change ◽  
Antigen Expression ◽  
Phase Contrast Microscopy ◽  
Activated Platelets ◽  
Contrast Microscopy ◽  
Age And Sex

SummaryDetermination of circulating activated platelets may be helpful to estimate the prognosis and to stratify therapies in arterial vascular disorders including stroke. We used flow cytometry and phase contrast microscopy to study whether the fraction of platelets expressing p-selectin and CD63 and the fraction of platelets with shape change are increased in patients with acute and previous cerebrovascular ischemia.The proportion of platelets expressing activation dependent antigens was higher in patients with acute (n = 24; p-selectin: 8.23 ± 4.21%; CD63: 3.53 ± 2.53%) and with previous cerebrovascular ischemia (n = 46; 3.86 ± 1.98%; 2.80 ± 1.79%) as compared to age- and sex-matched control subjects (n = 35; 2.17 ± 0.96%; 1.79 ± 0.75%; p ≤0.005, respectively). In patients with previous ischemia, there was no difference between treatment with aspirin (n = 25) or phenprocoumon (n = 21). Hypertension, diabetes mellitus and smoking were not associated with increased antigen expression (analysis of variance). The fraction of discoid platelets and platelet counts were not significantly different between groups.Our results indicate increased expression of platelet neoantigens in acute and to a less degree in previous cerebrovascular ischemia. Ongoing platelet activation after cerebrovascular ischemia despite therapy with aspirin or phenprocoumon indicates that new anti-platelet drugs may be of benefit for these patients. Flow cytometry appears to be a useful tool to assess platelet function in cerebrovascular ischemia.

Abstract 165: Platelet Derived Growth Factor (pdgf) is Associated With Progression of Symptomatic Intracranial Large Artery Atherosclerosis

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Sang-Wuk Jeong
Keyword(s):  
Logistic Model ◽  
Matched Control ◽  
Univariate Analysis ◽  
Platelet Derived Growth Factor ◽  
Smoking History ◽  
Tnf Alpha ◽  
Large Artery ◽  
Risk Of Progression ◽  
The Relationship ◽  
Age And Sex

Background and Purpose: Studies on the molecular pathways involved in the progression of intracranial large artery atherosclerosis are rare. We aimed to study the relationship between biomarkers and the risk of progression of symptomatic intracranial large artery atherosclerosis. Methods: Of 409 patients in Trial of cilostazol in symptomatic intracranial stenosis-2 (TOSS-2) study, 52 patients showed progression of symptomatic intracranial large artery atherosclerosis on MRA after 7 months. We selected 20 patients with progression and 40 age- and sex- matched control patients. We collected blood sample initially, one month and 7 month after infarction, and multiplex analysis of biomarkers including interleukin-1,2,6,8,10, soluble CD40ligand, TNF alpha, PDGF, soluble ICAM, E-selectin and VCAM , MMP-2,3,9, SOD1,2,3 and adipokines, were performed. Results: Demographic features such as age, sex, hypertension, diabetes and smoking history were not different between both groups. On univariate analysis, 7 month PDGF-AA (3053 ± 2896 pg/ml, vs 1444±1548 pg/ml), PDGF-AB/BB (15304.0±15634 pg/ml vs 5627±8656 pg/ml) level and MPO(25.7±33.9vs 9.9±8.7ng/ml) were higher in progression group. On multivariate analysis using logistic model, 7 month PDGF AA is independent prognostic factor for progression of intracranial large artery atherosclerosis (p=0.012). Conclusion: PDGF-AB/BB level is associated with progression of symptomatic intracranial large artery atherosclerosis.

Rousseau

Kinesic Humor ◽  
2021 ◽  
pp. 81-92
Author(s):  
Guillemette Bolens
Keyword(s):  
Emotional State ◽  
Emotional Experiences ◽  
The Impact ◽  
Vital Action

Jean-Jacques Rousseau expressed the need to be genuinely understood. This need is manifest in the precision with which he describes in his Confessions the kinesthetic valence of his emotional experiences and the impact kinesic dialogues had on him. Several of the kinesic dialogues he records in his autobiography revolve around surprising shifts in tonicity, tone, and tempo in verbal utterances, gestures, and the vital action of breathing. This chapter considers four such passages, including a scene of writing in which Rousseau’s emotional state is specifically communicated by the very fact that his handwriting is unreadable owing to the trembling of his hand.

Uncovering Relationships Between Emotional States and Higher-Order Needs

2013 ◽  
Vol 3 (1) ◽  
pp. 31-46 ◽  
Author(s):  
Andrew Pressey ◽  
Laura Salciuviene ◽  
Stuart Barnes
Keyword(s):  
Survey Data ◽  
Virtual Worlds ◽  
Second Life ◽  
Emotional State ◽  
Higher Order ◽  
Emotional States ◽  
Emotional Experiences ◽  
Informed Decisions ◽  
Computer Mediated ◽  
Self Actualization

The purpose of the study is to examine the effects of emotional states on higher-order need attainment in the computer-mediated environment. A survey data were collected from 404 adult visitors within the Second Life of virtual worlds. The findings suggest that the emotional states exert significant effects on attainment of higher-order needs (i.e. belongingness, esteem and self-actualization); the flow emotional state exerts a greater effect on attaining higher-order needs than the remaining emotional states of anxiety, confusion and apathy. Companies with presence in the Second Life of virtual worlds will be able to make more informed decisions when directing their efforts to enhance visitors’ emotional experiences in their virtual islands.

Emotional Control in Adulthood

1997 ◽  
Vol 80 (2) ◽  
pp. 499-507 ◽  
Author(s):  
Jasmin Tahmaseb McConatha ◽  
Frances Marshall Leone ◽  
Jill M. Armstrong
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Emotional Control ◽  
Emotional Intensity ◽  
Socioemotional Selectivity Theory ◽  
Emotional Experiences ◽  
Men And Women ◽  
Socioemotional Selectivity ◽  
Similarities And Differences ◽  
Age And Sex

Although it is widely believed that emotions vary with age, there is a dearth of information on emotional experiences in later adulthood. Several researchers think that older adults experience less emotional intensity than younger people while others have suggested that aging is accompanied by a decrease in positive affect and an increase in negative emotions. Sex similarities and differences in emotionality have also been documented. This study focuses on age and sex similarities and differences in emotional control. Three hundred and twenty seven men and women aged 19 to 92 years were administered two emotion measures. The results support previous research which suggests that the control of emotions increases with age. In evaluating sex differences in emotional control, women scored as more emotionally expressive than men, a finding which is consistent with previous research. Results are discussed in relation to socioemotional selectivity theory.

Increased Concentrations of Total IgM At Clinical Onset of Type 1 (Insulin-Dependent) Diabetes: Correlation with IgM Binding to Cells. The Belgian Diabetes Registry

1992 ◽  
Vol 38 (9) ◽  
pp. 1762-1767 ◽  
Author(s):  
T Decraene ◽  
C Vandewalle ◽  
D Pipeleers ◽  
F K Gorus
Keyword(s):  
Matched Control ◽  
Islet Cells ◽  
Insulin Dependent Diabetes ◽  
Diabetes Registry ◽  
Control Subjects ◽  
Clinical Onset ◽  
Natural Autoantibodies ◽  
Insulin Dependent ◽  
Age And Sex

Abstract Eighty patients with type 1 (insulin-dependent) diabetes (ages 0-39 years) were consecutively recruited by the Belgian Diabetes Registry. Sera obtained at clinically diagnosed onset (i.e., before start of insulin therapy or within 7 days of initial treatment) were analyzed for total IgM concentrations and for IgM binding to fixed rat splenocytes (IgM-LyAb) and permeabilized rat islet cells (IgM-ICAb). Comparison of results with those in age- and sex-matched control subjects, by fluorescence-activated cell-sorter analysis, indicated greater concentrations of IgM-LyAb and IgM-ICAb in sera from the patients. IgM antibodies reacted indiscriminately with islet beta and islet endocrine non-beta cells. The prevalence of IgM-ICAb, but not of IgM-LyAB, was significantly (P less than 0.05) higher in patients than in the control subjects. Of the ICAb-positive patients, 54% were also LyAb-positive, whereas none of the control subjects were doubly positive. IgM-ICAb and IgM-LyAb binding signals were positively correlated. Serum IgM concentrations were significantly (P less than 0.001) greater in patients than in control subjects and were significantly correlated with IgM-LyAb (P less than 0.001) and IgM-ICAb (P less than 0.01). The positivity for IgM binding was not, however, merely a reflection of total IgM, because no such correlation was found in sera from seven patients with Waldenström macroglobulinemia. Clinical onset of type 1 diabetes is apparently accompanied by increased production of IgM. The correlation between IgM concentrations and IgM binding to islet cells might reflect polyclonal activation or natural autoantibodies.

Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4+ T cells in thymomas

Blood ◽  
2002 ◽  
Vol 100 (1) ◽  
pp. 159-166 ◽  
Author(s):  
Philipp Ströbel ◽  
Markus Helmreich ◽  
Georgios Menioudakis ◽  
Sharon R. Lewin ◽  
Thomas Rüdiger ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Myasthenia Gravis ◽  
Cell Sorting ◽  
Cd4 T Cells ◽  
Matched Control ◽  
Cell Subset ◽  
Autoreactive T Cells ◽  
T Cell Subset ◽  
Age And Sex

Abstract Myasthenia gravis (MG) is the leading paraneoplastic manifestation of thymomas and is probably related to the capacity of thymomas to mature and export potentially autoreactive T cells. Why some thymomas are MG associated (MG+) and others are not (MG−) has been unclear. We addressed this question by comparing the percentages of intratumorous naive mature CD45RA+ thymocytes in 9 MG(+) and in 13 MG(−) thymomas by fluorescence-activated cell sorting analysis. Our results show that intratumorous naive CD4 T cells were present in all MG(+) thymomas and in one MG(−) thymoma with the development of MG only 2 months after surgery. By contrast, the percentage of naive CD4+ T cells was significantly reduced in all 13 MG(−) thymomas (P < .0001). Alterations in intratumorous thymopoiesis were reflected by corresponding alterations of naive T-cell subset composition in the blood, in that only MG(−) patients had significantly decreased levels (P = .02) of naive CD4+ T cells compared with age- and sex-matched control persons. We conclude that paraneoplastic MG is highly associated with the efficiency of thymomas to produce and export naive CD4+T cells. The acquisition of the CD45RA+ phenotype on CD4+ T cells during terminal intratumorous thymopoiesis is associated with the presence of MG in most thymoma patients.

Migraine and Left-Handedness are not Associated. A New Case—Control Study and Meta-Analysis

Cephalalgia ◽  
2008 ◽  
Vol 28 (5) ◽  
pp. 553-557 ◽  
Author(s):  
K Biehl ◽  
A Frese ◽  
M Marziniak ◽  
I-W Husstedt ◽  
S Evers
Keyword(s):  
Diagnostic Criteria ◽  
Case Control Study ◽  
Matched Control ◽  
International Headache Society ◽  
Meta Analysis ◽  
Case Control ◽  
Left Handedness ◽  
Significant Difference ◽  
Control Study ◽  
Age And Sex

To investigate the possible association between migraine and left-handedness, we enrolled 100 patients with a diagnosis of migraine according to the International Headache Society diagnostic criteria and 100 age- and sex-matched control subjects into a case—control study. Handedness was determined by the Edinburgh Handedness Inventory. There was no significant difference in the frequency or grade of left-handedness between the two groups. Additionally, we pooled our data with those from five similar studies, which did not alter the result. Thus, neither our study nor the meta-analysis support Geschwind and Behan's hypothesis of an association between migraine and left-handedness.

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