scholarly journals Comparison between radial artery tonometry pulse analyzer and pulsed-Doppler echocardiography derived hemodynamic parameters in cardiac surgery patients: a pilot study

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e4132 ◽  
Author(s):  
Rashad Zayat ◽  
Andreas Goetzenich ◽  
Ju-Yeon Lee ◽  
HeeJung Kang ◽  
So-Hyun Jansen-Park ◽  
...  
Keyword(s):  
Pilot Study ◽  
Radial Artery ◽  
Pearson Correlation ◽  
Hemodynamic Parameters ◽  
Altman Analysis ◽  
Limits Of Agreement ◽  
Bland Altman Analysis ◽  
Number Of Patients ◽  
The Mean ◽  
Lower Limits

BackgroundBedside non-invasive techniques, such as radial artery tonometry, to estimate hemodynamic parameters have gained increased relevance as an attractive alternative and efficient method to measure hemodynamics in outpatient departments. For our pilot study, we sought to compare cardiac output (CO), and stroke volume (SV) estimated from a radial artery tonometry blood pressure pulse analyzer (BPPA) (DMP-Life, DAEYOMEDI Co., Gyeonggi-do, South Korea) to pulsed-wave Doppler (PWD) echocardiography derived parameters.MethodsFrom January 2015 to December 2016, all patients scheduled for coronary artery bypass (CABG) surgery at our department were screened. Exclusion criteria were, inter alia, moderate to severe aortic- or Mitral valve disease and peripheral arterial disease (PAD) > stage II. One hundred and seven patients were included (mean age 66.1 ± 9.9, 15 females, mean BMI 27.2 ± 4.1 kg/m2). All patients had pre-operative transthoracic echocardiography (TTE). We measured the hemodynamic parameters with the BPPA from the radial artery, randomly before or after TTE. For the comparison between the measurement methods we used the Bland-Altman test and Pearson correlation.ResultsMean TTE-CO was 5.1 ± 0.96 L/min, and the mean BPPA-CO was 5.2 ± 0.85 L/min. The Bland-Altman analysis for CO revealed a bias of −0.13 L/min and SD of 0.90 L/min with upper and lower limits of agreement of −1.91 and +1.64 L/min. The correlation of CO measurements between DMP-life and TTE was poor (r = 0.501,p < 0.0001). The mean TTE-SV was 71.3 ± 16.2 mL and the mean BPPA-SV was 73.8 ± 19.2 mL. SV measurements correlated very well between the two methods (r = 0.900,p < 0.0001). The Bland-Altman analysis for SV revealed a bias of −2.54 mL and SD of ±8.42 mL and upper and lower limits of agreement of −19.05 and +13.96 mL, respectively.ConclusionOur study shows for the first time that the DMP-life tonometry device measures SV and CO with reasonable accuracy and precision of agreement compared with TTE in preoperative cardiothoracic surgery patients. Tonometry BPPA are relatively quick and simple measuring devices, which facilitate the collection of cardiac and hemodynamic information. Further studies with a larger number of patients and with repeated measurements are in progress to test the reliability and repeatability of DMP-Life system.

scholarly journals COMPARISON BETWEEN RECTAL AND BODY SURFACE TEMPERATURES OBTAINED BY DIGITAL AND NON-CONTACT INFRARED THERMOMETER IN SOME LARGE ANIMAL SPECIES

2019 ◽  
Vol 7 (8) ◽  
pp. 62-68
Author(s):  
Mera Usman Muhammed ◽  
Mayaki Abubakar Musa ◽  
Gambo Abdulrahman Abdullahi
Keyword(s):  
Animal Species ◽  
Large Animal ◽  
Altman Analysis ◽  
Limits Of Agreement ◽  
Infrared Thermometer ◽  
Bland Altman Analysis ◽  
The Face ◽  
Body Temperature Measurement ◽  
The Mean ◽  
The Moment

This study was carried out to compare the digital rectal (DR) thermometer with non-contact infrared thermometer (IRT) measurements at two locations on the face in some large animal species. Two hundred and forty (240) animals comprising of equal numbers of three species (cattle, camel and horses) of varying age and either sex was used. The IR temperature was taken from two sites [frontal (FIRT) and temporal (TIRT) region] on the animal face. The mean IR temperatures (FIRT and TIRT) were higher than the RT in all the animal species. The two thermometers correlate poorly in all the animal species. Bland-Altman analysis showed high biases and limits of agreement not acceptable for clinical purposes. In conclusion, IRT seems to offer a quick and easy way to determine the animal temperature but clinically it cannot be used interchangeably with DR thermometer at the moment for body temperature measurement in these animal species.

VALIDITY OF THE RETROSPECTIVE APPLICATION OF OXFORD HIP AND KNEE SCORES

2015 ◽  
Vol 18 (01) ◽  
pp. 1550003
Author(s):  
Travis M. Falconer ◽  
Julie Headford ◽  
Stephen Edmondston ◽  
Piers J. Yates
Keyword(s):  
Positive Relationship ◽  
Oxford Knee Score ◽  
Knee Score ◽  
Altman Analysis ◽  
Limits Of Agreement ◽  
Bland Altman Analysis ◽  
Oxford Hip Score ◽  
The Mean ◽  
Mean Time

The Oxford Hip Score (OHS) and Oxford Knee Score (OKS) are validated, reliable and reproducible outcome measures, however their use retrospectively has not been examined. The aim of this prospective cohort study was to examine the accuracy and reliability of patients' ability to recall their OHS and OKS in a retrospective manner. A total of 137 patients undergoing primary hip (40) or primary knee (97) arthroplasty with a mean age of 70.8 years (range, 47–88) and a mean time to follow up of 27.2 months (range, 6–46) were included in the study. The mean retrospective OHS and OKS decreased compared to the pre-operative score (OHS = 1.6 ± SD, p = 0.36, OKS = 4.7 ± SD, p < 0.001). There was only a weak positive relationship between the actual pre-operative scores and the retrospective scores (OHS: r2 = 0.30, OKS: r2 = 0.19). Bland–Altman analysis demonstrated 95% limits of agreement between scores of -19.9 to 23.1 for the OHS and -15.3 to 24.8 for the OKS. This study shows that patients are poor at retrospectively recalling their pre-operative OHS and OKS and therefore these scores should not be used in a retrospective manner.

scholarly journals Comparison of IOP Measurement by Goldmann Applanation Tonometer, ICare Rebound Tonometer, and Tono-Pen in Keratoconus Patients after MyoRing Implantation

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Mahmoud Rateb ◽  
Mahmoud Abdel-Radi ◽  
Zeiad Eldaly ◽  
Mohamed Nagy Elmohamady ◽  
Asaad Noor El Din
Keyword(s):  
Central Corneal Thickness ◽  
Pearson Correlation ◽  
Corneal Thickness ◽  
Altman Analysis ◽  
Bland Altman Analysis ◽  
Rebound Tonometer ◽  
Goldmann Applanation Tonometer ◽  
Significant Difference ◽  
Applanation Tonometer ◽  
Icare Rebound Tonometer

Purpose. To evaluate the different IOP readings by Goldmann applanation tonometer (GAT), ICare rebound tonometer, and Tono-Pen in keratoconus patients after MyoRing implantation. To assess the influence of central corneal thickness (CCT) and thinnest corneal location (TCL) on IOP measurements by different tonometers. Setting. Prospective observational study was conducted in two private centers in Egypt from February 2015 to November 2016. Methods. Seventeen eyes of 10 patients suffering from keratoconus and who underwent MyoRing implantation were recruited. All subjects underwent GAT, ICare, and Tono-Pen IOP measurements in random order. Central corneal thickness and thinnest corneal location were assessed by Pentacam. Difference in mean in IOP readings was assessed by T-test. Correlation between each pair of devices was evaluated by Pearson correlation coefficient. The Bland–Altman analysis was used to assess intertonometer agreement. Results. Seventeen eyes (10 patients) were evaluated. The mean IOP reading was 13.9 ± 3.68, 12.41 ± 2.87, and 14.29 ± 1.31 mmHg in GAT, ICare, and Tono-Pen group, respectively. There was a significant difference between IOP readings by GAT/ICare and Tono-Pen/ICare (p value: 0.032 and 0.002, respectively) with no significant difference between GAT/Tono-Pen (p value: 0.554). Mean difference in IOP measurements between GAT/ICare was 1.49 ± 2.61 mmHg, Tono-Pen/ICare was 1.89 ± 2.15 mmHg, and GAT/Tono-Pen was −0.39 ± 2.59 mmHg. There was no significant correlation between the difference in IOP readings among any pair of devices and CCC or TCL. The Bland–Altman analysis showed a reasonable agreement between any pair of tonometers.

The Accuracy and Reproducibility of Linear Measurements Made on CBCT-derived Digital Models

2016 ◽  
Vol 17 (4) ◽  
pp. 294-299 ◽  
Author(s):  
Mohammad Y Hajeer ◽  
Ahmad L Maroua ◽  
Mowaffak Ajaj
Keyword(s):  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Intraobserver Reliability ◽  
Altman Analysis ◽  
Digital Models ◽  
Linear Measurements ◽  
Bland Altman Analysis ◽  
Accuracy Of Measurements ◽  
The Mean ◽  
Plaster Models

ABSTRACT Objective To evaluate the accuracy and reproducibility of linear measurements made on cone-beam computed tomography (CBCT)-derived digital models. Materials and methods A total of 25 patients (44% female, 18.7 ± 4 years) who had CBCT images for diagnostic purposes were included. Plaster models were obtained and digital models were extracted from CBCT scans. Seven linear measurements from predetermined landmarks were measured and analyzed on plaster models and the corresponding digital models. The measurements included arch length and width at different sites. Paired t test and Bland–Altman analysis were used to evaluate the accuracy of measurements on digital models compared to the plaster models. Also, intraclass correlation coefficients (ICCs) were used to evaluate the reproducibility of the measurements in order to assess the intraobserver reliability. Results The statistical analysis showed significant differences on 5 out of 14 variables, and the mean differences ranged from −0.48 to 0.51 mm. The Bland–Altman analysis revealed that the mean difference between variables was (0.14 ± 0.56) and (0.05 ± 0.96) mm and limits of agreement between the two methods ranged from −1.2 to 0.96 and from −1.8 to 1.9 mm in the maxilla and the mandible, respectively. The intraobserver reliability values were determined for all 14 variables of two types of models separately. The mean ICC value for the plaster models was 0.984 (0.924–0.999), while it was 0.946 for the CBCT models (range from 0.850 to 0.985). Conclusion Linear measurements obtained from the CBCTderived models appeared to have a high level of accuracy and reproducibility. How to cite this article Maroua AL, Ajaj M, Hajeer MY. The Accuracy and Reproducibility of Linear Measurements Made on CBCT-derived Digital Models. J Contemp Dent Pract 2016;17(4):294-299.

scholarly journals Comparison of two methods for measurement of equine adrenocorticotropin

2017 ◽  
Vol 30 (2) ◽  
pp. 233-237 ◽  
Author(s):  
Heidi E. Banse ◽  
Nichol Schultz ◽  
Molly McCue ◽  
Ray Geor ◽  
Dianne McFarlane
Keyword(s):  
Pars Intermedia ◽  
Plasma Samples ◽  
Altman Analysis ◽  
Poor Agreement ◽  
Limits Of Agreement ◽  
Cutoff Value ◽  
Bland Altman Analysis ◽  
Acth Concentration

Accurate measurement of equine adrenocorticotropin (ACTH) is important for the diagnosis of equine pituitary pars intermedia dysfunction (PPID). Several radioimmunoassays (RIAs) and chemiluminescent immunoassays (CIAs) are used for measurement of ACTH concentration in horses; whether these methods yield similar results across a range of concentrations is not determined. We evaluated agreement between a commercial RIA and CIA. Archived plasma samples ( n = 633) were measured with both assays. Correlation between the 2 methods was moderate ( r = 0.49, p < 0.001). Bland–Altman analysis revealed poor agreement, with a proportional bias and widening limits of agreement with increasing values. Poor agreement between assays was also observed when evaluating plasma samples with concentrations at or below the recommended diagnostic cutoff value for PPID testing. The lack of agreement suggests that measurements obtained should not be considered interchangeable between methods.

scholarly journals Better Performance of Flow-FISH in Comparison to qPCR As a Diagnostic Test for Telomere Diseases

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 1605-1605
Author(s):  
Fernanda Gutierrez-Rodrigues ◽  
Bárbara A Santana-Lemos ◽  
Priscila Santos Scheucher ◽  
Raquel M Alves-Paiva ◽  
Rodrigo T. Calado
Keyword(s):  
Telomere Length ◽  
Diagnostic Test ◽  
Quantitative Pcr ◽  
Measurement Techniques ◽  
Healthy Individuals ◽  
Altman Analysis ◽  
Poor Agreement ◽  
Limits Of Agreement ◽  
Gold Standard Method ◽  
Bland Altman Analysis

Abstract Excessive telomere erosion is the molecular etiology of a group of disorders (dyskeratosis congenita, aplastic anemia, idiopathic pulmonary fibrosis) collectively called telomeropathies. Telomere length measurement is an essential diagnostic test for these diseases. The most commonly used methods are terminal restriction fragment (TRF) analysis by Southern blotting (the gold-standard method), flow cytometry combined with fluorescence in situ hybridization (flow-FISH), and quantitative PCR (qPCR). Although the clinical use of these methods has been reported, their utility and characteristics have not been widely compared. Measurement techniques and coefficients of variations often differ among diagnostic services. Here, we directly compared the accuracy, reproducibility, sensitivity, and specificity of flow-FISH and qPCR in comparison to TRF to measure peripheral blood leukocyte’s telomere length in healthy individuals and patients with telomeropathies. TRF analyses and flow-FISH showed good correlation in the analysis of samples from healthy subjects (R2=0.60; p<0.0001) and patients (R2=0.51; p<0.0001). Bland-Altman analyses also displayed a very good agreement between these methods for both healthy individuals (bias±SD = 0.17±1.03; limits of agreement ranging from 2.24 to -1.88) and patients (bias±SD = 0.0±1.21; limits of agreement ranging from 2.41 to -2.41). In contrast, the comparison between TRF and qPCR yielded modest correlation for the analysis of samples of healthy individuals (R2=0.35; p<0.0001) and low correlation for patients (R2=0.20; p=0.001). Bland-Altman analysis indicated poor agreement between the two methods for both patients and controls. The differences averages were very different from zero and standard deviation was wide. For patients, the bias±SD was 0.78±1.34 with limits of agreement ranging from 3.47 to -1.90, and for controls, the bias±SD was 1.15±1.49 with limits of agreement ranging from 4.14 to -1.84. Finally, qPCR and flow-FISH also modestly correlated in the analysis of healthy individual samples (R2=0.33; p<0.0001) and did not correlate in the comparison of patients’ samples (R2=0.1, p=0.08). Bland-Altman analysis corroborate this finding. For controls, the bias±SD were very similar to the one found by comparison between qPCR and TRF analysis (-0.6±1.27; limits of agreement ranging from 1.94 to -3.16). For patients, bias ± SD were -1.15 ± 1.65 with limits of agreement ranging from 2.15 to -4.45, which evidenced a poor agreement between flow-FISH and qPCR in these samples. Intra-assay coefficient of variation (CV) was 10.8±7.1% for flow-FISH and 9.5±7.4% for qPCR (p=0.35). The inter-assay CV was lower for flow-FISH (9.6±7.6%) in comparison to qPCR (16±19.5%; p=0.02). Flow-FISH and qPCR were sensitive (both 100%) and specific (93% and 89%, respectively) to distinguish very short telomeres. However, qPCR sensitivity (40%) and specificity (63%) to detect telomere length below tenth percentile were lower in comparison to flow-FISH (80% sensitivity and 85% specificity). Taken together, these findings indicate that, in the clinical setting, flow-FISH is more accurate and reproducible in the measurement of human leukocyte’s telomere length in comparison to qPCR. Quantitative PCR exhibited low accuracy in the analysis of samples of patients with short telomeres. In conclusion, flow-FISH appears to be a more appropriate method for diagnostic purposes. Studies that compare methodologies are helpful in the selection of standard methods and to narrow the differences among laboratories. Disclosures No relevant conflicts of interest to declare.

scholarly journals The Reliability and Test-Retest Stability of the Treatment Perception Questionnaire (TPQ) in the Oncology Field: A Pilot Study

2021 ◽  
Vol 17 (1) ◽  
pp. 324-330
Author(s):  
Federica Sancassiani ◽  
Sara Gambino ◽  
Jutta Lindert ◽  
Lapo Sali ◽  
Irene Pinna ◽  
...  
Keyword(s):  
Limits Of Agreement ◽  
Good Reliability ◽  
Retest Reliability ◽  
The United Kingdom ◽  
Oncological Diseases ◽  
The Mean ◽  
Test Retest Reliability ◽  
Lower Limits ◽  
Total Test

Background: Patients' satisfaction is an indicator of technical, instrumental, environmental, and interpersonal aspects of care. It shows how much the health service “as a whole organization” meets the patients’ psychosocial expectations and if the health professionals combine their technical competence with relational skills. The Treatment Perception Questionnaire (TPQ) is a brief instrument developed in the United Kingdom for research with substance abuse disorder populations. The present study aimed at evaluating the reliability and test-retest stability of the TPQ Italian translation in a sample of patients with solid and blood cancers. Methods: The TPQ was administered to 263 people with solid and blood cancers. Test-retest reliability was evaluated in a subgroup of 116 participants who completed the TPQ again after 3 months. Results: The reliability of TPQ was good. Cronbach’s alpha: 0.83 (95%CI: 0.79-0.86), 0.66 (0.59-0.72), 0.71 (0.65-0.769), respectively, in the total test, and in subscales on “staff perception”, and “program perception”. Test-retest reliability was 0.82 (0.77-0.87). The mean difference between the first and the second assessment was 1.0 (SD = 7.1; 95% CI -0.35 to 2.33). By plotting the differences and the means of the two assessments, 5/116 cases (4.3%) were outside the upper and lower limits of agreement. Conclusions: This study points out good reliability and test-retest stability of the TPQ in the oncology field. The TPQ can be used to assess variation over time about satisfaction with care in patients with oncological diseases, favoring the identification of unmet patients’ needs about the quality of the service.

scholarly journals Comparing School-Aged Refraction Measurements Using the 2WIN-S Portable Refractor in Relation to Cycloplegic Retinoscopy: A Cross-Sectional Study

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Ziming Liu ◽  
Emmanuel Eric Pazo ◽  
Hong Ye ◽  
Cui Yu ◽  
Ling Xu ◽  
...  
Keyword(s):  
Gold Standard ◽  
Intraclass Correlation ◽  
Cross Sectional Study ◽  
Mean Value ◽  
Spherical Equivalent ◽  
Sectional Study ◽  
Altman Analysis ◽  
Cross Sectional ◽  
Bland Altman Analysis ◽  
The Mean

Purpose. To assess the repeatability and agreement of refractive measurements using 2WIN-S photoscreening with the gold-standard cycloplegic retinoscope refraction. Design. Single centre, cross-sectional study. Methods. Spherical, cylindrical, axis, and spherical equivalent of 194 bilateral eyes of 97 children were assessed using a retinoscope and 2WIN-S. One week later, another operator repeated the 2WIN-S measurements. The primary outcome measures were to assess the repeatability and agreement between spherical equivalent, J0, and J45 readings of 2WIN-S. The repeatability of measurements was assessed by the within-subject standard deviation (2.77 Sw) and intraclass correlation coefficient (ICC). The agreement between devices was assessed using 95% limits of agreement. The extent of the agreement between cycloplegic retinoscopy and noncycloplegic 2WIN-S measurements was assessed using Bland–Altman analysis. Results. The mean age ± SD was 10.3 ± 2.46 year (range, 4–14 years). The sphere, cylinder, and spherical equivalent measurements were found to be consistent with both apparatus (r value >0.86). ICC for SE, J0, and J45 was 0.900, 0.666, and 0.639, respectively; Sw for SE, J0, and J45 was 0.61D, 0.30D, and 0.31D, respectively; Bland–Altman analysis of retinoscopy with cycloplegia and 2WIN-S for SE was 184/194 (95%) in 95% confidence interval, and the mean value was 0.46. J0 was 184/194 (95%), and the mean value is −0.04. J45 was 181/194 (93%), and the mean value is −0.15. Conclusion. The objective refractive measurement of 2WIN-S had good reliability and high agreement with the gold-standard retinoscopy refraction in children and adolescents. While consistency was observed, it is essential to take into consideration that it is a screening tool.

scholarly journals Inter-Operator Reliability of an Onsite Machine Learning-Based Prototype to Estimate Ct Angiography-Derived Fractional Flow Reserve

2021 ◽  
Author(s):  
Yushui Han ◽  
Ahmed Ibrahim Ahmed ◽  
Chris Schwemmer ◽  
Myra Cocker ◽  
Talal S Alnabelsi ◽  
...  
Keyword(s):  
Machine Learning ◽  
Sensitivity Analysis ◽  
Ct Angiography ◽  
Coronary Ct Angiography ◽  
Altman Analysis ◽  
Fractional Flow ◽  
Limits Of Agreement ◽  
Bland Altman Analysis ◽  
Coronary Ct ◽  
Flow Reserve

Abstract Background: Advances in computed tomography (CT) and machine learning have enabled on-site non-invasive assessment of fractional flow reserve (FFRCT). Purpose: To assess the inter-operator variability of Coronary CT Angiography–derived FFRCT using a machine learning based post-processing prototype.Materials and Methods: We included 60 symptomatic patients who underwent coronary CT angiography. FFRCT was calculated by 2 independent operators after training using a machine learning based on-site prototype. FFRCT was measured 1 cm distal to the coronary plaque or in the middle of the segments if no coronary lesions were present. Intraclass correlation coefficient (ICC) and Bland-Altman analysis were used to evaluate inter-operator variability effect in FFRCT estimates. Sensitivity analysis was done by cardiac risk factors, degree of stenosis and image quality. Results: A total of 535 coronary segments in 60 patients were assessed. The overall ICC was 0.986 per patient (95% CI: 0.977 - 0.992) and 0.972 per segment (95% CI: 0.967 - 0.977). The absolute mean difference in FFRCT estimates was 0.012 per patient (95% CI for limits of agreement: -0.035 - 0.039) and 0.02 per segment (95% CI for limits of agreement: -0.077 - 0.080). Tight limits of agreement were seen on Bland-Altman analysis. Distal segments had greater variability compared to proximal/mid segments (absolute mean difference 0.011 vs 0.025, p<0.001). Results were similar on sensitivity analysis. Conclusion: A high degree of inter-operator reproducibility can be achieved by onsite machine learning based FFRCT assessment. Future research is required to evaluate the physiological relevance and prognostic value of FFRCT.

Sign in / Sign up

Export Citation Format

Share Document