scholarly journals THE EFFECT OF COMBINED EXERCISE TRAINING ON CAROTID ARTERY STRUCTURE AND FUNCTION, AND VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) IN OBESE OLDER WOMEN

2010 ◽  
Vol 59 (5) ◽  
pp. 495-504 ◽  
Author(s):  
JINKEE PARK ◽  
YOSHIO NAKAMURA ◽  
YOOCHAN KWON ◽  
HYUNTAE PARK ◽  
EUNHEE KIM ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Carotid Artery ◽  
Exercise Training ◽  
Older Women ◽  
Structure And Function ◽  
Vascular Endothelial ◽  
Combined Exercise ◽  
And Function ◽  
Endothelial Growth Factor

scholarly journals Leptin Matures Aspects of Lung Structure and Function in the Ovine Fetus

Endocrinology ◽  
2016 ◽  
Vol 157 (1) ◽  
pp. 395-404 ◽  
Author(s):  
Miles J. De Blasio ◽  
Maria Boije ◽  
Sarah L. Kempster ◽  
Gordon C. S. Smith ◽  
D. Stephen Charnock-Jones ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Structure And Function ◽  
Mrna Levels ◽  
Vascular Endothelial ◽  
Lung Structure ◽  
Lung Compartment ◽  
Ovine Fetus ◽  
And Function ◽  
Endothelial Growth Factor

Abstract In human and ovine fetuses, glucocorticoids stimulate leptin secretion, although the extent to which leptin mediates the maturational effects of glucocorticoids on pulmonary development is unclear. This study investigated the effects of leptin administration on indices of lung structure and function before birth. Chronically catheterized singleton sheep fetuses were infused iv for 5 days with either saline or recombinant ovine leptin (0.5 mg/kg · d leptin (LEP), 0.5 LEP or 1.0 mg/kg · d, 1.0 LEP) from 125 days of gestation (term ∼145 d). Over the infusion, leptin administration increased plasma leptin, but not cortisol, concentrations. On the fifth day of infusion, 0.5 LEP reduced alveolar wall thickness and increased the volume at closing pressure of the pressure-volume deflation curve, interalveolar septal elastin content, secondary septal crest density, and the mRNA abundance of the leptin receptor (Ob-R) and surfactant protein (SP) B. Neither treatment influenced static lung compliance, maximal lung volume at 40 cmH2O, lung compartment volumes, alveolar surface area, pulmonary glycogen, protein content of the long form signaling Ob-Rb or phosphorylated signal transducers and activators of transcription-3, or mRNA levels of SP-A, C, or D, elastin, vascular endothelial growth factor-A, the vascular endothelial growth factor receptor 2, angiotensin-converting enzyme, peroxisome proliferator-activated receptor γ, or parathyroid hormone-related peptide. Leptin administration in the ovine fetus during late gestation promotes aspects of lung maturation, including up-regulation of SP-B.

Local Delivery of Vascular Endothelial Growth Factor Accelerates Reendothelialization and Attenuates Intimal Hyperplasia in Balloon-Injured Rat Carotid Artery

Circulation ◽  
1995 ◽  
Vol 91 (11) ◽  
pp. 2793-2801 ◽  
Author(s):  
Takayuki Asahara ◽  
Christophe Bauters ◽  
Christopher Pastore ◽  
Marianne Kearney ◽  
Susan Rossow ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Carotid Artery ◽  
Intimal Hyperplasia ◽  
Local Delivery ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Myocyte vascular endothelial growth factor is required for exercise-induced skeletal muscle angiogenesis

2010 ◽  
Vol 299 (4) ◽  
pp. R1059-R1067 ◽  
Author(s):  
I. Mark Olfert ◽  
Richard A. Howlett ◽  
Peter D. Wagner ◽  
Ellen C. Breen
Keyword(s):  
Skeletal Muscle ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Exercise Training ◽  
Metabolic Adaptation ◽  
Vascular Endothelial ◽  
Vegf Expression ◽  
Running Speed ◽  
Endothelial Growth Factor ◽  
Adaptation To Exercise

We have previously shown, using a Cre-LoxP strategy, that vascular endothelial growth factor (VEGF) is required for the development and maintenance of skeletal muscle capillarity in sedentary adult mice. To determine whether VEGF expression is required for skeletal muscle capillary adaptation to exercise training, gastrocnemius muscle capillarity was measured in myocyte-specific VEGF gene-deleted (mVEGF−/−) and wild-type (WT) littermate mice following 6 wk of treadmill running (1 h/day, 5 days/wk) at the same running speed. The effect of training on metabolic enzyme activity levels and whole body running performance was also evaluated in mVEGF−/− and WT mice. Posttraining capillary density was significantly increased by 59% ( P < 0.05) in the deep muscle region of the gastrocnemius in WT mice but did not change in mVEGF−/− mice. Maximal running speed and time to exhaustion during submaximal running increased by 20 and 13% ( P < 0.05), respectively, in WT mice after training but were unchanged in mVEGF−/− mice. Training led to increases in skeletal muscle citrate synthase (CS) and phosphofructokinase (PFK) activities in both WT and mVEGF−/− mice ( P < 0.05), whereas β-hydroxyacyl-CoA dehydrogenase (β-HAD) activity was increased only in WT mice. These data demonstrate that skeletal muscle capillary adaptation to physical training does not occur in the absence of myocyte-expressed VEGF. However, skeletal muscle metabolic adaptation to exercise training takes place independent of myocyte VEGF expression.

scholarly journals Myoferlin Regulates Vascular Endothelial Growth Factor Receptor-2 Stability and Function

2007 ◽  
Vol 282 (42) ◽  
pp. 30745-30753 ◽  
Author(s):  
Pascal N. Bernatchez ◽  
Lisette Acevedo ◽  
Carlos Fernandez-Hernando ◽  
Takahisa Murata ◽  
Cecile Chalouni ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
And Function ◽  
Endothelial Growth Factor
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