scholarly journals Structure and function of vascular endothelial growth factor and its receptor system

BMB Reports ◽  
2018 ◽  
Vol 51 (2) ◽  
pp. 73-78 ◽  
Author(s):  
Seong Ah Park ◽  
Mi Suk Jeong ◽  
Ki-Tae Ha ◽  
Se Bok Jang
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Structure And Function ◽  
Vascular Endothelial ◽  
Receptor System ◽  
And Function ◽  
Endothelial Growth Factor

scholarly journals Leptin Matures Aspects of Lung Structure and Function in the Ovine Fetus

Endocrinology ◽  
2016 ◽  
Vol 157 (1) ◽  
pp. 395-404 ◽  
Author(s):  
Miles J. De Blasio ◽  
Maria Boije ◽  
Sarah L. Kempster ◽  
Gordon C. S. Smith ◽  
D. Stephen Charnock-Jones ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Structure And Function ◽  
Mrna Levels ◽  
Vascular Endothelial ◽  
Lung Structure ◽  
Lung Compartment ◽  
Ovine Fetus ◽  
And Function ◽  
Endothelial Growth Factor

Abstract In human and ovine fetuses, glucocorticoids stimulate leptin secretion, although the extent to which leptin mediates the maturational effects of glucocorticoids on pulmonary development is unclear. This study investigated the effects of leptin administration on indices of lung structure and function before birth. Chronically catheterized singleton sheep fetuses were infused iv for 5 days with either saline or recombinant ovine leptin (0.5 mg/kg · d leptin (LEP), 0.5 LEP or 1.0 mg/kg · d, 1.0 LEP) from 125 days of gestation (term ∼145 d). Over the infusion, leptin administration increased plasma leptin, but not cortisol, concentrations. On the fifth day of infusion, 0.5 LEP reduced alveolar wall thickness and increased the volume at closing pressure of the pressure-volume deflation curve, interalveolar septal elastin content, secondary septal crest density, and the mRNA abundance of the leptin receptor (Ob-R) and surfactant protein (SP) B. Neither treatment influenced static lung compliance, maximal lung volume at 40 cmH2O, lung compartment volumes, alveolar surface area, pulmonary glycogen, protein content of the long form signaling Ob-Rb or phosphorylated signal transducers and activators of transcription-3, or mRNA levels of SP-A, C, or D, elastin, vascular endothelial growth factor-A, the vascular endothelial growth factor receptor 2, angiotensin-converting enzyme, peroxisome proliferator-activated receptor γ, or parathyroid hormone-related peptide. Leptin administration in the ovine fetus during late gestation promotes aspects of lung maturation, including up-regulation of SP-B.

scholarly journals Myoferlin Regulates Vascular Endothelial Growth Factor Receptor-2 Stability and Function

2007 ◽  
Vol 282 (42) ◽  
pp. 30745-30753 ◽  
Author(s):  
Pascal N. Bernatchez ◽  
Lisette Acevedo ◽  
Carlos Fernandez-Hernando ◽  
Takahisa Murata ◽  
Cecile Chalouni ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
And Function ◽  
Endothelial Growth Factor

Iberian pig early pregnancy: Vascular endothelial growth factor receptor system expression in the maternofetal interface in healthy and arresting conceptuses

2015 ◽  
Vol 83 (3) ◽  
pp. 334-343 ◽  
Author(s):  
R.A. García Fernández ◽  
M.A. Sánchez Pérez ◽  
B. Sánchez Maldonado ◽  
P. García-Palencia ◽  
C. Naranjo Freixa ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Early Pregnancy ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Receptor System ◽  
Iberian Pig ◽  
Endothelial Growth Factor

scholarly journals Vascular Endothelial Growth Factor D Is Dispensable for Development of the Lymphatic System

2005 ◽  
Vol 25 (6) ◽  
pp. 2441-2449 ◽  
Author(s):  
Megan E. Baldwin ◽  
Michael M. Halford ◽  
Sally Roufail ◽  
Richard A. Williams ◽  
Margaret L. Hibbs ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Lymphatic Vessels ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Wild Type ◽  
Tissue Mass ◽  
And Function ◽  
Endothelial Growth Factor ◽  
Deficient Mice

ABSTRACT Vascular endothelial growth factor receptor 3 (Vegfr-3) is a tyrosine kinase that is expressed on the lymphatic endothelium and that signals for the growth of the lymphatic vessels (lymphangiogenesis). Vegf-d, a secreted glycoprotein, is one of two known activating ligands for Vegfr-3, the other being Vegf-c. Vegf-d stimulates lymphangiogenesis in tissues and tumors; however, its role in embryonic development was previously unknown. Here we report the generation and analysis of mutant mice deficient for Vegf-d. Vegf-d-deficient mice were healthy and fertile, had normal body mass, and displayed no pathologic changes consistent with a defect in lymphatic function. The lungs, sites of strong Vegf-d gene expression during embryogenesis in wild-type mice, were normal in Vegf-d-deficient mice with respect to tissue mass and morphology, except that the abundance of the lymphatics adjacent to bronchioles was slightly reduced. Dye uptake experiments indicated that large lymphatics under the skin were present in normal locations and were functional. Smaller dermal lymphatics were similar in number, location, and function to those in wild-type controls. The lack of a profound lymphatic phenotype in Vegf-d-deficient mice suggests that Vegf-d does not play a major role in lymphatic development or that Vegf-c or another, as-yet-unknown activating Vegfr-3 ligand can compensate for Vegf-d during development.

Sign in / Sign up

Export Citation Format

Share Document