Current Status and Therapeutic Perspectives for the Stem Cells Treatment of Ischemic Stroke

2012 ◽  
Vol 32 (3) ◽  
pp. 134
Author(s):  
Hyun Young Kim
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Current Status

scholarly journals Modern Concepts in Regenerative Therapy for Ischemic Stroke: From Stem Cells for Promoting Angiogenesis to 3D-Bioprinted Scaffolds Customized via Carotid Shear Stress Analysis

2019 ◽  
Vol 20 (10) ◽  
pp. 2574 ◽  
Author(s):  
Annabella Benedek ◽  
Daniel Cernica ◽  
Andras Mester ◽  
Diana Opincariu ◽  
Roxana Hodas ◽  
...  
Keyword(s):  
Stem Cells ◽  
Shear Stress ◽  
Ischemic Stroke ◽  
Therapeutic Angiogenesis ◽  
Current Status ◽  
Regenerative Therapy ◽  
Therapeutic Approaches ◽  
Ischemic Brain ◽  
Promising Tool ◽  
3D Geometry

Ischemic stroke is associated with a tremendous economic and societal burden, and only a few therapies are currently available for the treatment of this devastating disease. The main therapeutic approaches used nowadays for the treatment of ischemic brain injury aim to achieve reperfusion, neuroprotection and neurorecovery. Therapeutic angiogenesis also seems to represent a promising tool to improve the prognosis of cerebral ischemia. This review aims to present the modern concepts and the current status of regenerative therapy for ischemic stroke and discuss the main results of major clinical trials addressing the effectiveness of stem cell therapy for achieving neuroregeneration in ischemic stroke. At the same time, as a glimpse into the future, this article describes modern concepts for stroke prevention, such as the implantation of bioprinted scaffolds seeded with stem cells, whose 3D geometry is customized according to carotid shear stress.

Exosomes from Human Urine-Derived Stem Cells Promote Neurogenesis Via Histone Deacetylase6 Regulation in Ischemic Stroke

2018 ◽  
Author(s):  
Xiaozheng Ling ◽  
Guowei Zhang ◽  
Qingwei Zhu ◽  
Juntao Zhang ◽  
Qing Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Human Urine

Stem Cell Transplantation: A Promising Therapy for Spinal Cord Injury

2020 ◽  
Vol 15 (4) ◽  
pp. 321-331 ◽  
Author(s):  
Zhe Gong ◽  
Kaishun Xia ◽  
Ankai Xu ◽  
Chao Yu ◽  
Chenggui Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Therapeutic Potential ◽  
Embryonic Stem ◽  
Current Status ◽  
Cord Injury

Spinal Cord Injury (SCI) causes irreversible functional loss of the affected population. The incidence of SCI keeps increasing, resulting in huge burden on the society. The pathogenesis of SCI involves neuron death and exotic reaction, which could impede neuron regeneration. In clinic, the limited regenerative capacity of endogenous cells after SCI is a major problem. Recent studies have demonstrated that a variety of stem cells such as induced Pluripotent Stem Cells (iPSCs), Embryonic Stem Cells (ESCs), Mesenchymal Stem Cells (MSCs) and Neural Progenitor Cells (NPCs) /Neural Stem Cells (NSCs) have therapeutic potential for SCI. However, the efficacy and safety of these stem cellbased therapy for SCI remain controversial. In this review, we introduce the pathogenesis of SCI, summarize the current status of the application of these stem cells in SCI repair, and discuss possible mechanisms responsible for functional recovery of SCI after stem cell transplantation. Finally, we highlight several areas for further exploitation of stem cells as a promising regenerative therapy of SCI.

scholarly journals Current status of endovascular therapy for acute ischemic stroke

2013 ◽  
Vol 53 (11) ◽  
pp. 1166-1168
Author(s):  
Hiroshi Yamagami ◽  
Nobuyuki Sakai
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Endovascular Therapy ◽  
Current Status

scholarly journals Mesenchymal Stem Cells Overexpressing Interleukin-10 Promote Neuroprotection in Experimental Acute Ischemic Stroke

2017 ◽  
Vol 6 ◽  
pp. 102-111 ◽  
Author(s):  
Masataka Nakajima ◽  
Chikako Nito ◽  
Kota Sowa ◽  
Satoshi Suda ◽  
Yasuhiro Nishiyama ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Interleukin 10

Current Status of Stem Cells and Regenerative Medicine Research in Argentina

2014 ◽  
Vol 23 (S1) ◽  
pp. 17-19 ◽  
Author(s):  
Fernando J. Pitossi ◽  
Osvaldo L. Podhajcer
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Current Status ◽  
Medicine Research
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