Current Status of Stem Cells and Regenerative Medicine Research in Argentina

2014 ◽  
Vol 23 (S1) ◽  
pp. 17-19 ◽  
Author(s):  
Fernando J. Pitossi ◽  
Osvaldo L. Podhajcer
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Current Status ◽  
Medicine Research

RESEARCH FINDINGS

2011 ◽  
Vol 15 (12) ◽  
pp. 43-44
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Kawasaki Disease ◽  
Regenerative Medicine ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Medicine Research ◽  
Research Findings ◽  
Cell Study

Singapore Scientists Lead Human Embryonic Stem Cell Study to Advance Regenerative Medicine Research. Singapore Scientists Discover Genetic Link in Kawasaki Disease. Stem Cells Engineered to Kill Cancer.

Contact us for more information: an analysis of public enquiries about stem cells

2019 ◽  
Vol 14 (12) ◽  
pp. 1137-1150 ◽  
Author(s):  
Amy Zarzeczny ◽  
Claire Tanner ◽  
Jan Barfoot ◽  
Clare Blackburn ◽  
Anna Couturier ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Qualitative Analysis ◽  
Medicine Research ◽  
The Public ◽  
Related Information ◽  
Stem Cell Science ◽  
Research Initiatives

Aim: This study examines online enquiries received by two prominent stem cell science initiatives operating in different geographical jurisdictions. Materials & methods: Combined quantitative and qualitative analysis undertaken of internet-based queries (n = 1047) received by Stem Cells Australia and EuroStemCell from members of the public over a two-year period (May 2014–2016). Results: Findings reveal striking similarities between the two datasets and highlight the range of uncertainties, priorities and needs of those seeking information about stem cells online. Conclusion: Sustained and in-depth tailored guidance is needed to effectively meet the diverse stem cell-related information-based needs of communities internationally. Such efforts should be prioritized by regenerative medicine research initiatives and organizations, given the trust and hope diverse publics appear to place in these groups.

scholarly journals Advances in mesenchymal stem cell exosomes: a review

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yaya Tang ◽  
Yan Zhou ◽  
Hong-Jun Li
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Targeted Delivery ◽  
Tissue Repair ◽  
Medical Problems ◽  
Medicine Research ◽  
Paracrine Signalling ◽  
Tissue Repair And Regeneration ◽  
In Vitro Expansion

AbstractStem cells can be used for regenerative medicine and as treatments for disease. The application of tissue engineering-related transplantation, stem cells, and local changes in the microenvironment is expected to solve major medical problems. Currently, most studies focus on tissue repair and regeneration, and mesenchymal stem cells (MSCs) are among the most common research topics. MSCs are applicable as seed cells, and they represent one of the current hot topics in regenerative medicine research. However, due to storage limitations and because cell senescence occurs during in vitro expansion, their clinical application is challenging. Exosomes, which are secreted by MSCs through paracrine signalling, not only have the same effects as MSCs, but they also have the advantages of targeted delivery, low immunogenicity, and high repairability. This article reviews the acquisition methods, characteristics, biological functions, and clinical applications of exosomes.

Rg1 promotes the proliferation and adipogenic differentiation of human adipose-derived stem cells via FXR1/Lnc-GAS5-AS1 pathway

2021 ◽  
Vol 16 ◽  
Author(s):  
Fang-Tian Xu ◽  
Yin-Li Xu ◽  
Yong-Xian Rong ◽  
Dong-Lin Huang ◽  
Zhong-Hong Lai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Signaling Pathway ◽  
Regulatory Network ◽  
Transcriptional Regulatory Network ◽  
Adipogenic Differentiation ◽  
Cell Counting ◽  
Adipose Derived Stem Cells ◽  
Alizarin Red ◽  
Medicine Research

Background: Human adipose-derived stem cells (hASCs) play an important role in regenerative medicine. Objective: Exploring the mechanism of Rg1 in the promotion of the proliferation and adipogenic differentiation of hASCs is important in regenerative medicine research. Methods: In order to observe ginsenoside Rg1 in promoting the proliferation and adipogenic differentiation of hASCs, Rg1 medium at different concentrations was established and tested using the cell counting kit-8 (CCK-8) assay, oil red O staining, alizarin red, and alcian blue. Compared to the control, differentially expressed genes (DEGs) were screened via DEG analysis, which were carried out in the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. To explore the relationship among mRNA, long non-coding RNA (lncRNA) and microRNA (miRNA), we constructed a competing endogenous RNA (ceRNA) network. Results: In this study, Rg1 was observed to promote the proliferation and adipogenic differentiation of hASCs. Additionally, enriched BPs and KEGG pathways may be involved in the promotion process, where FXR1 and Lnc-GAS5-AS1 were found to be regulatory factors. The regulatory network suggested that Rg1 could regulate the adipocytokine signaling pathway and IL−17 signaling pathway via FXR1 and Lnc-GAS5-AS1, which served as the mechanism encompassing the promotion of Rg1 on the proliferation and adipogenic differentiation of hASCs. Conclusion: A comprehensive transcriptional regulatory network related to the promotion ability of Rg1 was constructed, revealing mechanisms regarding Rg1’s promotion of the proliferation and adipogenic differentiation of hASCs. The present study provides a theoretical basis in optimizing the function of hASCs.

scholarly journals LifeMap Discovery™: The Embryonic Development, Stem Cells, and Regenerative Medicine Research Portal

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e66629 ◽  
Author(s):  
Ron Edgar ◽  
Yaron Mazor ◽  
Ariel Rinon ◽  
Jacob Blumenthal ◽  
Yaron Golan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Embryonic Development ◽  
Medicine Research

scholarly journals Current Status and Future Prospects of Perinatal Stem Cells

Genes ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 6
Author(s):  
Paz de la Torre ◽  
Ana I. Flores
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Cord Blood ◽  
New Technologies ◽  
Primary Source ◽  
Cell Types ◽  
Current Status ◽  
Clinical Settings ◽  
Hematopoietic Stem

The placenta is a temporary organ that is discarded after birth and is one of the most promising sources of various cells and tissues for use in regenerative medicine and tissue engineering, both in experimental and clinical settings. The placenta has unique, intrinsic features because it plays many roles during gestation: it is formed by cells from two individuals (mother and fetus), contributes to the development and growth of an allogeneic fetus, and has two independent and interacting circulatory systems. Different stem and progenitor cell types can be isolated from the different perinatal tissues making them particularly interesting candidates for use in cell therapy and regenerative medicine. The primary source of perinatal stem cells is cord blood. Cord blood has been a well-known source of hematopoietic stem/progenitor cells since 1974. Biobanked cord blood has been used to treat different hematological and immunological disorders for over 30 years. Other perinatal tissues that are routinely discarded as medical waste contain non-hematopoietic cells with potential therapeutic value. Indeed, in advanced perinatal cell therapy trials, mesenchymal stromal cells are the most commonly used. Here, we review one by one the different perinatal tissues and the different perinatal stem cells isolated with their phenotypical characteristics and the preclinical uses of these cells in numerous pathologies. An overview of clinical applications of perinatal derived cells is also described with special emphasis on the clinical trials being carried out to treat COVID19 pneumonia. Furthermore, we describe the use of new technologies in the field of perinatal stem cells and the future directions and challenges of this fascinating and rapidly progressing field of perinatal cells and regenerative medicine.

Amniotic fluid-derived stem cells in regenerative medicine research

2012 ◽  
Vol 35 (2) ◽  
pp. 271-280 ◽  
Author(s):  
Sunyoung Joo ◽  
In Kap Ko ◽  
Anthony Atala ◽  
James J. Yoo ◽  
Sang Jin Lee
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Amniotic Fluid ◽  
Medicine Research
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