scholarly journals EFFECT OF HIGH-DENSITY ORAL RABIES VACCINE BAITING ON RABIES VIRUS NEUTRALIZING ANTIBODY RESPONSE IN RACCOONS (PROCYON LOTOR)

2019 ◽  
Vol 55 (2) ◽  
pp. 399 ◽  
Author(s):  
Kerri Pedersen ◽  
Amy T. Gilbert ◽  
Eric S. Wilhelm ◽  
Kathleen M. Nelson ◽  
Amy J. Davis ◽  
...  
Keyword(s):  
Antibody Response ◽  
Rabies Virus ◽  
Procyon Lotor ◽  
Neutralizing Antibody ◽  
Rabies Vaccine ◽  
High Density ◽  
Oral Rabies Vaccine

scholarly journals Raccoon (Procyon lotor) biomarker and rabies antibody response to varying oral rabies vaccine bait densities in northwestern Pennsylvania

Heliyon ◽  
2018 ◽  
Vol 4 (9) ◽  
pp. e00754 ◽  
Author(s):  
Kerri Pedersen ◽  
Brandon S. Schmit ◽  
Thomas J. DeLiberto ◽  
Jason R. Suckow ◽  
Amy J. Davis ◽  
...  
Keyword(s):  
Antibody Response ◽  
Procyon Lotor ◽  
Rabies Vaccine ◽  
Oral Rabies Vaccine

scholarly journals No adverse effects of simultaneous vaccination with the immunocontraceptive GonaCon™ and a commercial rabies vaccine on rabies virus neutralizing antibody production in dogs

Vaccine ◽  
2009 ◽  
Vol 27 (51) ◽  
pp. 7210-7213 ◽  
Author(s):  
Scott C. Bender ◽  
David L. Bergman ◽  
Krista M. Wenning ◽  
Lowell A. Miller ◽  
Dennis Slate ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Rabies Virus ◽  
Antibody Production ◽  
Neutralizing Antibody ◽  
Rabies Vaccine

scholarly journals Oral vaccination of foxes and raccoon dogs against rabies with the 3rd generation oral rabies virus vaccine, SPBN GASGAS, in Finland

2021 ◽  
Vol 63 (1) ◽  
Author(s):  
Ad Vos ◽  
Tiina Nokireki ◽  
Marja Isomursu ◽  
Tuija Gadd ◽  
Ferenc Kovacs
Keyword(s):  
Rabies Virus ◽  
Virus Vaccine ◽  
Field Performance ◽  
Rabies Vaccine ◽  
Red Foxes ◽  
Suitable Alternative ◽  
Generation Vaccine ◽  
Significant Difference ◽  
Oral Rabies Vaccine ◽  
Raccoon Dogs

Abstract Background To prevent re-emergence of wildlife-mediated rabies in Finland, oral rabies vaccine baits are distributed every year during autumn in southern Finland in a vaccination zone bordering Russia. Recently, Finland introduced a 3rd generation oral rabies virus vaccine bait. By analysing bait uptake and seroconversion in red foxes and raccoon dogs, the field efficacy of this new vaccine strain, SPBN GASGAS, was compared with the originally used highly efficacious 1st generation vaccine SAD B19. Results Overall, 74.6% and 53.9% of the animals submitted from the vaccination area after the campaigns (2017–2019) tested positive for the presence of the bait marker and anti-rabiesvirus antibodies, respectively. No significant difference was observed between years, species and vaccine. Conclusions The field performance of the highly attenuated 3rd generation oral rabies vaccine, SPBN GASGAS, in terms of bait uptake and seroconversion was similar to the 1st generation vaccine, SAD B19, and therefore offers a suitable alternative.

scholarly journals Rabies Virus-specific Human T Cell Clones Provide Help for an in vitro Antibody Response against Neutralizing Antibody-inducing Determinants of the Viral Glycoprotein

1989 ◽  
Vol 70 (6) ◽  
pp. 1513-1521 ◽  
Author(s):  
H. Bunschoten ◽  
R. J. Klapmuts ◽  
I. J. Th. M. Claassen ◽  
S. D. Reyneveld ◽  
A. D. M. E. Osterhaus ◽  
...  
Keyword(s):  
T Cell ◽  
Antibody Response ◽  
Rabies Virus ◽  
Neutralizing Antibody ◽  
Viral Glycoprotein ◽  
T Cell Clones ◽  
Human T Cell ◽  
Cell Clones

scholarly journals Humoral Immune Response of Thai Dogs after Oral Vaccination against Rabies with the SPBN GASGAS Vaccine Strain

Vaccines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 573
Author(s):  
Kansuda Leelahapongsathon ◽  
Suwicha Kasemsuwan ◽  
Tanu Pinyopummintr ◽  
Orawan Boodde ◽  
Parinya Phawaphutayanchai ◽  
...  
Keyword(s):  
Immune Response ◽  
Oral Administration ◽  
Rabies Virus ◽  
Vaccine Strain ◽  
Humoral Immune Response ◽  
Rabies Vaccine ◽  
Oral Vaccination ◽  
Specific Antibodies ◽  
Humoral Immune ◽  
Oral Rabies Vaccine

Applied research is crucial in pushing the boundaries and finding a solution to the age-old problem of dog-mediated rabies. Although oral vaccination of dogs is considered to have great potential in mass dog vaccination campaigns and could have far-reaching benefits, it is perhaps the most ignored of all available tools in efforts to eliminate dog-mediated rabies, not least because of limited data on immunogenicity, efficacy, and safety of potential oral rabies vaccine candidates. In this study, the long-term immunogenicity in local Thai dogs after oral administration of the highly attenuated 3rd generation rabies virus vaccine strain SPBN GASGAS was assessed. The oral rabies vaccine was administered to dogs by either direct oral administration (n = 10) or by offering a vaccine loaded intestine bait (n = 15). The humoral immune response was then compared to three groups of dogs; a group that received a parenteral delivered inactivated rabies vaccine (n = 10), a group offered a placebo intestine bait (n = 7), and a control group (n = 4) for an observation period of 365 days. There was no significant difference in the immune response of dogs that received oral and parenteral vaccine in terms of magnitude, kinetics, and persistence of both rabies virus (RABV) neutralizing (RFFIT) and binding (ELISA) antibodies. Although the single parenteral injection of an inactivated rabies vaccine mounted a slightly higher humoral immune response than the orally delivered live vaccine, RABV specific antibodies of both types were still detectable after one year in most animals for all treatment groups and resulted in no difference in seropositivity. Characterization of rabies specific antibodies revealed two main classes of antibodies involved in the immune response of dogs vaccinated. While IgM antibodies were the first to appear, the succeeding IgG response was mainly IgG2 dominated independent of the vaccine type used. The results support the view that SPBN GASGAS induces a sustained detectable immune response in local dogs both after direct oral administration and via bait application.

scholarly journals Recombinant rabies virus expressing dog GM-CSF is an efficacious oral rabies vaccine for dogs

Oncotarget ◽  
2015 ◽  
Vol 6 (36) ◽  
pp. 38504-38516 ◽  
Author(s):  
Ming Zhou ◽  
Lei Wang ◽  
Songqin Zhou ◽  
Zhao Wang ◽  
Juncheng Ruan ◽  
...  
Keyword(s):  
Rabies Virus ◽  
Rabies Vaccine ◽  
Gm Csf ◽  
Oral Rabies Vaccine

The Early Kinetics of the Neutralizing Antibody Response after Booster Immunizations with Human Diploid Cell Rabies Vaccine

1986 ◽  
Vol 35 (3) ◽  
pp. 663-670 ◽  
Author(s):  
Daniel B. Fishbein ◽  
Kenneth W. Bernard ◽  
Lawrence B. Schonberger ◽  
John W. Sumner ◽  
Robert A. Parker ◽  
...  
Keyword(s):  
Antibody Response ◽  
Neutralizing Antibody ◽  
Diploid Cell ◽  
Rabies Vaccine ◽  
Human Diploid Cell ◽  
Kinetics Of

scholarly journals Serological Responses of Raccoons and Striped Skunks to Ontario Rabies Vaccine Bait in West Virginia during 2012–2016

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 157
Author(s):  
Shylo R. Johnson ◽  
Dennis Slate ◽  
Kathleen M. Nelson ◽  
Amy J. Davis ◽  
Samual A. Mills ◽  
...  
Keyword(s):  
West Virginia ◽  
Rabies Virus ◽  
Neutralizing Antibody ◽  
Rabies Vaccine ◽  
Striped Skunk ◽  
Eastern Usa ◽  
Wildlife Populations ◽  
Raccoon Rabies Virus ◽  
Striped Skunks ◽  
Rabies Vaccination

Since the 1990s, oral rabies vaccination (ORV) has been used successfully to halt the westward spread of the raccoon rabies virus (RV) variant from the eastern continental USA. Elimination of raccoon RV from the eastern USA has proven challenging across targeted raccoon (Procyon lotor) and striped skunk (Mephitis mephitis) populations impacted by raccoon RV. Field trial evaluations of the Ontario Rabies Vaccine Bait (ONRAB) were initiated to expand ORV products available to meet the rabies management goal of raccoon RV elimination. This study describes the continuation of a 2011 trial in West Virginia. Our objective was to evaluate raccoon and skunk response to ORV occurring in West Virginia for an additional two years (2012–2013) at 75 baits/km2 followed by three years (2014–2016) of evaluation at 300 baits/km2. We measured the change in rabies virus-neutralizing antibody (RVNA) seroprevalence in targeted wildlife populations by comparing levels pre- and post-ORV during each year of study. The increase in bait density from 75/km2 to 300/km2 corresponded to an increase in average post-ORV seroprevalence for raccoon and skunk populations. Raccoon population RVNA levels increased from 53% (300/565, 95% CI: 50–57%) to 82.0% (596/727, 95% CI: 79–85%) during this study, and skunk population RVNA levels increased from 11% (8/72, 95% CI: 6–20%) to 39% (51/130, 95% CI: 31–48%). The RVNA seroprevalence pre-ORV demonstrated an increasing trend across study years for both bait densities and species, indicating that multiple years of ORV may be necessary to achieve and maintain RVNA seroprevalence in target wildlife populations for the control and elimination of raccoon RV in the eastern USA.

scholarly journals Experimental rabies infection in haematophagous bats Desmodus rotundus

2005 ◽  
Vol 133 (3) ◽  
pp. 523-527 ◽  
Author(s):  
M. F. ALMEIDA ◽  
L. F. A. MARTORELLI ◽  
C. C. AIRES ◽  
P. C. SALLUM ◽  
E. L. DURIGON ◽  
...  
Keyword(s):  
Antibody Response ◽  
Rabies Virus ◽  
Neutralizing Antibodies ◽  
Fluorescent Antibody ◽  
Lethal Dose ◽  
Clinical Signs ◽  
Neutralizing Antibody ◽  
Pectoral Muscle ◽  
Desmodus Rotundus ◽  
Virus Dose

In order to determine the susceptibility and serum neutralizing antibody response of Desmodus rotundus to rabies virus, bats were inoculated with a virus isolated from a naturally infected haematophagous bat. Bats were divided into four groups of 10 animals each. Dilutions of rabies virus containing 100, 1000, 10000 and 100000 MICLD50 (lethal dose 50% for mice inoculated by the intracerebral route) were administrated in the pectoral muscle. The presence of rabies virus was detected in brain and salivary glands by fluorescent antibody, mouse inoculation and RT–PCR. The observed mortality for each virus dose was 0, 20, 20 and 60% respectively. Serum neutralizing antibodies were tested for by the rapid fluorescent focus inhibition test, and antibody titres greater than 0·5 IU/ml were found in 53% of bats 30 days after virus inoculation. Resistance to infection was seen in bats that developed low or no detectable antibody response as well as in bats with high titres. Among the 10 bats that died of rabies, eight showed signs of paralytic rabies and two bats showed no clinical signs.

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