Detection of Bisgaard Taxon 40 in Rhinoceros Auklets (Cerorhinca monocerata) with Pneumonia and Septicemia from a Mortality Event in Washington, USA

2019 ◽  
Vol 55 (1) ◽  
pp. 246
Author(s):  
Susan Knowles ◽  
Barbara L. Bodenstein ◽  
Brenda M. Berlowski-Zier ◽  
Susan M. Thomas ◽  
Scott F. Pearson ◽  
...  
Keyword(s):  
Mortality Event ◽  
Cerorhinca Monocerata

scholarly journals Outcomes associated with modern treatment paradigms in connective tissue disease (CTD)-associated pulmonary arterial hypertension (PAH): a meta-analysis of randomized controlled trials (RCTs)

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
V McLaughlin ◽  
C Zhao ◽  
J.G Coghlan ◽  
L.S Chung ◽  
S.C Mathai ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Treatment Effect ◽  
Meta Analysis ◽  
Response To Treatment ◽  
Funding Source ◽  
Class Iii ◽  
Inclusion Criteria ◽  
Private Company ◽  
Mortality Event

Abstract Background CTD-PAH has historically represented a PAH subtype with poor prognosis. New therapies, as well as combination therapy approaches targeting multiple pathways have been approved for PAH based on RCTs. CTD-PAH patients comprise a subgroup of the RCT populations and efficacy analyses are based on subgroup analyses which can be less reliable than the overall analysis. We conducted a meta-analysis of RCTs of approved PAH therapies to evaluate outcomes of patients with CTD-PAH. Purpose To use meta-analysis to determine response to treatment in patients with CTD-PAH. Methods The PubMed and EMBASE databases were searched for English-only articles published between January 1, 2000 and November 25, 2019. Inclusion criteria were multicenter RCTs that enrolled adults with WHO group 1 pulmonary hypertension (PAH); enrollment in 2000 or later; long-term clinical morbidity and/or mortality event or 6-minute walk distance (6MWD) as an efficacy endpoint reported for ≥30 patients with CTD-PAH; and evaluation of a US Food and Drug Administration-approved PAH therapy. The primary outcomes were treatment effect as measured by the study time to first morbidity or morality event and change in 6MWD from baseline to between 3–6 months, per the data provided in each article. Results from individual studies were combined using a random-effects model for overall study population (PAH patients) and the subgroup of CTD-PAH patients. Results Ten RCTs (N=4329 PAH patients; n=1263 (29%) with CTD-PAH) met inclusion criteria and were included in the meta-analysis. At baseline, PAH patients had a mean age of 50 years, approximately 78% were female, and approximately 58% had functional class III or IV disease. These characteristics were balanced between treatment and control groups. Baseline 6MWD was 356 m for the overall population and 337 m for patients with CTD-PAH. Five RCTs (N=3172; n=941 with CTD-PAH [30%]) reported hazard ratios (HRs) for time to a morbidity or mortality event by drug treatment and PAH etiology: overall population HR=0.63 (95% confidence interval [CI], 0.56–0.72; P<0.001); CTD-PAH population HR=0.64 (95% CI, 0.51–0.80; P<0.001) (Figure). Nine RCTs reported mean change with drug treatment from baseline to 3 to 6 months in 6MWD for PAH and CTD patients: 33.9 m (95% CI, 21.9–45.9; P<0.001) in the overall population; 20.2 m (95% CI, 10.8–29.7; P<0.001) in CTD-PAH patients. Conclusions The improvement in 6MWD in patients with CTD-PAH is smaller than in those with other types of PAH, perhaps reflecting comorbidities and CTD-induced mobility constraints, independent of their cardiopulmonary capacity. Data from long term clinical morbidity/mortality endpoint studies in this large group of patients with CTD-PAH demonstrate that these patients derive significant benefit from currently available PAH therapies which, in many patients, comprised the addition of a drug targeting a second or third pathway involved in the pathophysiology of PAH. Treatment effect on morbidity/mortality Funding Acknowledgement Type of funding source: Private company. Main funding source(s): Actelion Pharmaceuticals US, Inc.

scholarly journals Proximate Factors Determining Age and Mass at Fledging in Rhinoceros Auklets (Cerorhinca Monocerata): Intra- and Interyear Variations

The Auk ◽  
2004 ◽  
Vol 121 (2) ◽  
pp. 452-462 ◽  
Author(s):  
Tomohiro Deguchi ◽  
Akinori Takahashi ◽  
Yutaka Watanuki
Keyword(s):  
Growth Rate ◽  
Wing Length ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Major Effect ◽  
Timing Of Breeding ◽  
Hatching Date ◽  
Cerorhinca Monocerata ◽  
Parental Provisioning ◽  
Underlying Mechanisms

Abstract In alcids, growth rate and hatching date of chicks appear to affect fledging age and mass. Underlying mechanisms are hypothesized to be (1) critical wing length at fledging for postfledging survival, (2) synchronization of fledging to dilute predation risk, and (3) variable parental provisioning according to timing of breeding. To elucidate the effects of growth rate and hatching date on fledging age and mass, and to test those mechanistic hypotheses, we measured chick growth and fledging periods in Rhinoceros Auklets (Cerorhinca monocerata) at Teuri Island from 1995 to 2000. The multiple-linear regression analysis showed that intrayear variations of fledging age and mass were explained by growth rate or hatching date in five out of six years. Faster-growing chicks fledged younger and heavier, and earlier-hatched chicks fledged older and heavier. Consequently, no apparent correlation between fledging age and mass was observed in five out of six years. Analysis of interyear variation showed a negative correlation between fledging age and mass, which indicates that growth rates rather than hatching dates had a major effect. Wing length at fledging was independent of growth in mass. More than 80% of chicks fledged when they attained a narrow range of wing length (130–150 mm), presumably because they remained in their nests until they attained the critical wing length. In five out of six years, the chicks did not synchronize timing of fledging relative to timing of hatching. Later-hatched chicks attained lighter peak masses and at younger ages, which may indicate that their parents decreased provisioning rates when the chicks were still young. We suggest that (1) critical wing length at fledging and (2) variable parental provisioning according to timing of breeding could be underlying mechanisms determining these relationships between fledging age and mass.

First description of a mortality event in adult Pacific oysters in Italy associated with infection by a Tenacibaculum soleae strain

2017 ◽  
Vol 41 (2) ◽  
pp. 215-221 ◽  
Author(s):  
E A V Burioli ◽  
K Varello ◽  
S Trancart ◽  
E Bozzetta ◽  
A Gorla ◽  
...  
Keyword(s):  
Mortality Event ◽  
Pacific Oysters

scholarly journals Beached bachelors: An extensive study on the largest recorded sperm whale Physeter macrocephalus mortality event in the North Sea

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0201221 ◽  
Author(s):  
Lonneke L. IJsseldijk ◽  
Abbo van Neer ◽  
Rob Deaville ◽  
Lineke Begeman ◽  
Marco van de Bildt ◽  
...  
Keyword(s):  
North Sea ◽  
Sperm Whale ◽  
Extensive Study ◽  
Physeter Macrocephalus ◽  
Mortality Event ◽  
The North ◽  
The North Sea

Long-term declines in common breeding seabirds in Japan

2019 ◽  
Vol 30 (3) ◽  
pp. 434-446
Author(s):  
MASAYUKI SENZAKI ◽  
AKIRA TERUI ◽  
NAOKI TOMITA ◽  
FUMIO SATO ◽  
YOSHIHIRO FUKUDA ◽  
...  
Keyword(s):  
State Space Model ◽  
Common Species ◽  
Population Trends ◽  
Seabird Species ◽  
Common Murre ◽  
Cerorhinca Monocerata ◽  
Conservation Actions ◽  
Declining Species ◽  
The Japanese Archipelago

SummaryGlobal seabird populations are in decline, with nearly half of all seabird species currently in an extinction crisis. Understanding long-term seabird population trends is an essential first step to inform conservation actions. In this study, we assembled historical breeding records of seabirds throughout the Japanese archipelago and quantified the long-term population trends of 10 major breeding seabird species using a hierarchical Bayesian state-space model. The model revealed that six species had increasing or no detectable trends (Short-tailed Albatross Phoebastria albatrus, Leach’s Storm Petrel Oceanodroma leucorhoa, Pelagic Cormorant Phalacrocorax pelagicus, Japanese Cormorant Phalacrocorax capillatus, Spectacled Guillemot Cepphus carbo, and Rhinoceros Auklet Cerorhinca monocerata). However, decreasing trends were found not only in nationally threatened species (Common Murre Uria aalge, and Tufted Puffin Fratercula cirrhata) but also common species that are often described as abundant (Black-tailed Gull Larus crassirostris and Slaty-backed Gull Larus schistisagus). These declining species have declined to 3–35% of baseline levels over the past 30 years. This study provides the first evidence of long-term declines in common and widespread seabirds in Japan.

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