scholarly journals Author response: Response to Nodal morphogen gradient is determined by the kinetics of target gene induction

2015 ◽  
Author(s):  
Julien Dubrulle ◽  
Benjamin M Jordan ◽  
Laila Akhmetova ◽  
Jeffrey A Farrell ◽  
Seok-Hyung Kim ◽  
...  
Keyword(s):  
Target Gene ◽  
Gene Induction ◽  
Author Response ◽  
Morphogen Gradient ◽  
Target Gene Induction ◽  
Kinetics Of

scholarly journals Response to Nodal morphogen gradient is determined by the kinetics of target gene induction

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Julien Dubrulle ◽  
Benjamin M Jordan ◽  
Laila Akhmetova ◽  
Jeffrey A Farrell ◽  
Seok-Hyung Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Target Gene ◽  
Target Genes ◽  
Expression Patterns ◽  
Gene Induction ◽  
Morphogen Gradient ◽  
Morphogen Gradients ◽  
Zebrafish Embryogenesis ◽  
Target Gene Induction ◽  
Kinetics Of

Morphogen gradients expose cells to different signal concentrations and induce target genes with different ranges of expression. To determine how the Nodal morphogen gradient induces distinct gene expression patterns during zebrafish embryogenesis, we measured the activation dynamics of the signal transducer Smad2 and the expression kinetics of long- and short-range target genes. We found that threshold models based on ligand concentration are insufficient to predict the response of target genes. Instead, morphogen interpretation is shaped by the kinetics of target gene induction: the higher the rate of transcription and the earlier the onset of induction, the greater the spatial range of expression. Thus, the timing and magnitude of target gene expression can be used to modulate the range of expression and diversify the response to morphogen gradients.

scholarly journals Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction

FEBS Letters ◽  
1995 ◽  
Vol 360 (2) ◽  
pp. 137-143 ◽  
Author(s):  
Claudia Lütticken ◽  
Paul Coffer ◽  
Juping Yuan ◽  
Claudia Schwartz ◽  
Eric Caldenhoven ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Interleukin 6 ◽  
Target Gene ◽  
Gene Induction ◽  
Serine Phosphorylation ◽  
Target Gene Induction

scholarly journals Layer-Specific CREB Target Gene Induction in Human Neocortical Epilepsy

2012 ◽  
Vol 32 (41) ◽  
pp. 14389-14401a ◽  
Author(s):  
T. L. Beaumont ◽  
B. Yao ◽  
A. Shah ◽  
G. Kapatos ◽  
J. A. Loeb
Keyword(s):  
Target Gene ◽  
Gene Induction ◽  
Neocortical Epilepsy ◽  
Target Gene Induction

scholarly journals Insulin‐like Growth Factor‐1 Impacts p53 Target Gene Induction in UVB‐irradiated Keratinocytes and Human Skin

2020 ◽  
Vol 96 (6) ◽  
pp. 1332-1341
Author(s):  
Abdulrahman M.M. Alkawar ◽  
Amber J. Castellanos ◽  
Mae Alexandra Carpenter ◽  
Rebekah J. Hutcherson ◽  
Mariyyah A.O. Madkhali ◽  
...  
Keyword(s):  
Growth Factor ◽  
Human Skin ◽  
Target Gene ◽  
Gene Induction ◽  
Insulin Like Growth Factor ◽  
P53 Target Gene ◽  
Target Gene Induction

scholarly journals Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control

2017 ◽  
Vol 67 (5) ◽  
pp. 757-769.e5 ◽  
Author(s):  
Maxwell Z. Wilson ◽  
Pavithran T. Ravindran ◽  
Wendell A. Lim ◽  
Jared E. Toettcher
Keyword(s):  
Information Flow ◽  
Target Gene ◽  
Gene Induction ◽  
Combinatorial Control ◽  
Target Gene Induction
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