scholarly journals A Comparison of Pathogens in Skin and Soft Tissue Infections and Pedal Osteomyelitis in Puncture Wound Injuries Affecting the Foot

2020 ◽  
Author(s):  
David H Truong ◽  
Javier La Fontaine ◽  
Matthew Malone ◽  
Dane K Wukich ◽  
Kathryn E Davis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Bacterial Pathogen ◽  
Soft Tissue Infections ◽  
Puncture Wound ◽  
Common Pathogen ◽  
Patients With Diabetes

ObjectiveTo compare pathogens involved in skin and soft tissue infection (SSTI) and pedal osteomyelitis (OM) in patients with and without diabetes with puncture wounds to the foot. MethodsWe evaluated 113 consecutive patients between June 2011 and March 2019 with foot infection (SSTI and OM) from a puncture injury sustained to the foot. Eighty-three patients had diabetes (DM) and 30 did not (NDM). We evaluated the bacterial pathogens in patients with skin and soft tissue infections (SSTI) and pedal osteomyelitis (OM). ResultsPolymicrobial infection were more common in patients with diabetes mellitus (83.1% vs 53.3%, p=.001). The most common pathogen for SSTI and OM in DM was s. aureus (SSTI 50.7%, OM 32.3%), whereas in NDM patients it was Pseudomonas (25%) for SSTI. Anaerobes (9.4%) and fungal (3.1%) infection were uncommon. Pseudomonas aeruginosa was only identified in 5.8% of people with diabetes. ConclusionsThe most common bacterial pathogen in both SSTIs and pedal OM was staphylococcus aureus in patients with DM. Pseudomonas spp., was the most common pathogen in people without diabetes with SSTIs.

scholarly journals Efficacy of Lantibiotic Treatment of Staphylococcus aureus-Induced Skin Infections, Monitored byIn VivoBioluminescent Imaging

2016 ◽  
Vol 60 (7) ◽  
pp. 3948-3955 ◽  
Author(s):  
Anton Du Preez van Staden ◽  
Tiaan Heunis ◽  
Carine Smith ◽  
Shelly Deane ◽  
Leon M. T. Dicks
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Treatment Options ◽  
Bacterial Pathogen ◽  
Antimicrobial Activities ◽  
Skin Infections ◽  
Soft Tissue Infections ◽  
Content Type ◽  
Alternative Treatment Option

ABSTRACTStaphylococcus aureusis a bacterial pathogen responsible for the majority of skin and soft tissue infections. Antibiotics are losing their efficacy as treatment for skin and soft tissue infections as a result of increased resistance in a variety of pathogens, includingS. aureus. It is thus imperative to explore alternative antimicrobial treatments to ensure future treatment options for skin and soft tissue infections. A select few lantibiotics, a group of natural defense peptides produced by bacteria, inhibit the growth of numerous clinicalS. aureusisolates, including methicillin-resistant strains. In this study, the antimicrobial activities of nisin, clausin, and amyloliquecidin, separately administered, were compared to that of a mupirocin-based ointment, which is commonly used as treatment forS. aureus-induced skin infections. Full-thickness excisional wounds, generated on the dorsal surfaces of mice, were infected with a bioluminescent strain ofS. aureus(strain Xen 36). The infections were monitored in real time usingin vivobioluminescent imaging. Lantibiotic treatments significantly reduced the bioluminescence ofS. aureusXen 36 to a level similar to that recorded with mupirocin treatment. Wound closure, however, was more pronounced during lantibiotic treatment. Lantibiotics thus have the potential to be used as an alternative treatment option forS. aureus-induced skin infections.

scholarly journals Identifikasi Bakteri Infeksi Saluran Pernafasan Bawah Non Tuberkulosis (Non TB) dan Pola Resistensinya pada Penderita Diabetes Melitus di RSUP M. Djamil

2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Virgi Anggia Lubis ◽  
Yusticia Katar ◽  
Elizabeth Bahar
Keyword(s):  
Diabetes Mellitus ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Respiratory Infection ◽  
Bacterial Resistance ◽  
Klebsiella Pneumonia ◽  
Lower Respiratory Infection ◽  
Streptococcus Pneumonia ◽  
Medicine Department ◽  
Patients With Diabetes

AbstrakKadar gula darah yang tinggi pada pasien diabetes mellitus (DM) menyebabkan pasien ini rentan akan terjadinya infeksi, salah satunya infeksi saluran pernafasan bawah non tuberkulosis (Non TB) yang disebabkan oleh bakteri Gram negatif dan Gram positif, maka terapi pilihannya antibiotik spektrum luas. Survei awal di Bagian Penyakit Dalam RSUP M. Djamil didapatkan bahwa terapi yang dilakukan adalah terapi empiris yang  mengakibatkan meningkatnya resistensi. Tujuan penelitian ini adalah mengidentifikasi bakteri penyebab infeksi pernafasan bawah non tuberkulosis dan pola resistensinya pada penderita DM di  RSUP M. Djamil. Penelitian deskriptif ini dilakukan di Laboratorium Mikrobiologi FK Unand Padang dan Bagian Penyakit Dalam RSUP M. Djamil terhadap 16 pasien dengan diagnosis DM disertai infeksi saluran pernafasan bawah dari Januari sampai Februari 2014. Hasil penelitian menunjukkan Klebsiella pneumonia (56,25%) sebagai penyebab terbanyak, diikuti Staphylococcus aureus (18,25%), Pseudomonas aeruginosa (12,50%), dan Streptococcus pneumonia (12.50%). Uji resistensi menunjukkan Klebsiella pneumonia mengalami resistensi yang besar terhadap Ceftriaxone (66,63%), Pseudomonas aeruginosa resisten terhadap Ceftriaxone dan Amoxicilin Clavulanat Acid (50%), Staphylococcus aureus resisten terhadap Ciprofloxacin (33,33), sedangkan Streptococcus pneumonia  sensitif terhadap Azitromicin (100%). Dapat disimpulkan bakteri yang ditemukan mengalami resistensi yang cukup besar terhadap beberapa antibiotik yang digunakan.Kata kunci: diabetes melitus, infeksi saluran pernafasan bawah no TB, bakteri, resistensi AbstractHigh concentration of blood glucose in patients with diabetes mellitus cause susceptible to be infected, including lower respiratory infections non tuberculosis caused by Gram negatif and Gram positif. Treatment of these infections are broad spectrum antibiotics. The objective of this study was to indentify the causal bacteria of lower respiratory infection non tuberculous infection and the  bacterial resistance patterns in patients with diabetes mellitus in RSUP M. Djamil. From the primary survey in RSUP M. Djamil Internal Medicine Department, the treatment that usually used is empirical therapy that could increase risk of bacterial resistance. This descriptive study was conducted in Microbiology laboratory Medical Faculty of Andalas University and Inpatient Care of Internal Medicine Department of RSUP M. Djamil to 16 patients with Diabetes Mellitus and lower respiratory infection from January until February 2014. Culture result showed that Klebsiella pneumonia (56,25%)  was the main cause, followed by Staphylococcus aureus (18,25%), Pseudomonas aeruginosa (12,50%), and Streptococcus pneumonia(12,50%). Sensitivity test result shows that Klebsiella pneumonia has great resistance to Ceftriaxone (66,63%), Pseudomonas aeruginosa is resistant to Ceftriaxone and Amoxicilin Clavulanat Acid (50%), Staphylococcus aureus is resistant to Ciprofloxacin (33,33), while Streptococcus pneumonia is sensitive to Azitromicin (100%). It can be concluded that the bacteria found had a appreciable resistance to some antibiotics used.Keywords: diabetes mellitus, lower respiratory infection non TB, bacteria, resistance

Soft Tissue Infections: Necrotizing or Toxigenic

2012 ◽  
Author(s):  
John W. Wilson ◽  
Lynn L. Estes
Keyword(s):  
Diabetes Mellitus ◽  
Soft Tissue ◽  
Major Trauma ◽  
High Index ◽  
Immunocompromised Patients ◽  
Obese Patients ◽  
Soft Tissue Infections ◽  
Patients With Diabetes ◽  
Necrotizing Soft Tissue Infections ◽  
High Index Of Suspicion

• A high index of suspicion is critical in the diagnosis of necrotizing or toxigenic soft tissue infections.• Minor or major trauma can predispose patients to necrotizing soft tissue infections, which are more common in obese patients, patients with diabetes mellitus, and immunocompromised patients....

scholarly journals Staphylococcus aureus soft tissue infection may increase the risk of subsequent staphylococcal soft tissue infections

2017 ◽  
Vol 60 ◽  
pp. 44-48 ◽  
Author(s):  
Cindy Bouvet ◽  
Shpresa Gjoni ◽  
Besa Zenelaj ◽  
Benjamin A. Lipsky ◽  
Elif Hakko ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Soft Tissue Infections

Case Report: When all claims that it is necrotizing fasciitis but Point of care ultrasound (POCUS) proves the opposite!

POCUS Journal ◽  
2018 ◽  
Vol 3 (1) ◽  
pp. 13-14
Author(s):  
Hadiel Kaiyasah, MD, MRCS (Glasgow), ABHS-GS ◽  
Maryam Al Ali, MBBS
Keyword(s):  
Emergency Department ◽  
Critical Care ◽  
Case Report ◽  
Soft Tissue ◽  
Necrotizing Fasciitis ◽  
Soft Tissue Infection ◽  
Critical Care Unit ◽  
Point Of Care ◽  
Point Of Care Ultrasound ◽  
Soft Tissue Infections

Soft tissue ultrasound (ST-USS) has been shown to be of utmost importance in assessing patients with soft tissue infections in the emergency department or critical care unit. It aids in guiding the management of soft tissue infection based on the sonographic findings.

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