scholarly journals Research progress of biological effects of cell membrane under infrared and terahertz irradiation

2021 ◽  
Vol 70 (24) ◽  
pp. 248707-248707
Author(s):  
Bo Wen-Fei ◽  
◽  
Che Rong ◽  
Kong Lei ◽  
Zhang Ming-Jie ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Biological Effects ◽  
Research Progress ◽  
Terahertz Irradiation

scholarly journals Research progress on the antibacterial mechanisms of carvacrol: a mini review

2018 ◽  
Vol 1 (6) ◽  
pp. 71
Author(s):  
Dan Zhang ◽  
Ren-You Gan ◽  
Ying-Ying Ge ◽  
Qiong-Qiong Yang ◽  
Jiao Ge ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Antibacterial Activity ◽  
Quorum Sensing ◽  
Cell Membrane ◽  
Molecular Mechanisms ◽  
Food Preservation ◽  
Research Progress ◽  
Oxygen Species ◽  
Aromatic Plants ◽  
Volatile Oils

Background: Carvacrol is an aromatic phenolic terpenoid widely existing in the volatile oils of thyme, oregano, and some other aromatic plants. Recent studies have found that carvacrol possesses excellent antibacterial activity. In order to provide an updated information about the antibacterial potentials of carvacrol, herein, we summarized recent publications about the antibacterial activity of carvacrol, with special attention paid to its antibacterial molecular mechanisms, including desrupting cell membrane, depleting intracellular ATP, inducing reactive oxygen species, inhibiting efflux pumps, as well as suppressing two important virulence factors, biofilm and quorum sensing. In conclusion, carvacrol is a promising natural antibacterial compound with potential application in food preservation and infection.Keywords：Carvacrol, antibacterial mechanisms, biofilm, quorum sensing

scholarly journals Ultrasound microbubble contrast agent – carried chemotherapeutic drug microbubbles

2019 ◽  
Vol 131 ◽  
pp. 01015
Author(s):  
Junyang Song
Keyword(s):  
Contrast Agent ◽  
Biological Effects ◽  
Tumor Therapy ◽  
Development Prospect ◽  
Research Progress ◽  
Chemotherapeutic Drug ◽  
Invasive Treatment ◽  
Microbubble Contrast Agent ◽  
Chemotherapy Drugs ◽  
Non Invasive

With the continuous research and development of ultrasound microbubble contrast agent-carried chemotherapeutic drug microbubbles, ultrasound microbubble contrast agent not only facilitates the early detection and early diagnosis of tumors but also provides a new direction and development prospect for the drug delivery route. With a broad development prospect, it is expected to become a new safe, effective and non-invasive treatment. This paper reviews the biological effects and research progress of contrast-enhanced microbubble-loaded chemotherapy drugs in tumor therapy.

scholarly journals PC 12 Pheochromocytoma Cell Response to Super High Frequency Terahertz Radiation from Synchrotron Source

Cancers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 162 ◽  
Author(s):  
Palalle Perera ◽  
Dominique Appadoo ◽  
Samuel Cheeseman ◽  
Jason Wandiyanto ◽  
Denver Linklater ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Cell Membrane ◽  
Electromagnetic Radiation ◽  
High Frequency ◽  
Biological Effects ◽  
Cell Membrane Permeability ◽  
Temporary Increase ◽  
Thz Radiation ◽  
Synchrotron Source ◽  
Pc 12 Cells

High frequency (HF) electromagnetic fields (EMFs) have been widely used in many wireless communication devices, yet within the terahertz (THz) range, their effects on biological systems are poorly understood. In this study, electromagnetic radiation in the range of 0.3–19.5 × 1012 Hz, generated using a synchrotron light source, was used to investigate the response of PC 12 neuron-like pheochromocytoma cells to THz irradiation. The PC 12 cells remained viable and physiologically healthy, as confirmed by a panel of biological assays; however, exposure to THz radiation for 10 min at 25.2 ± 0.4 °C was sufficient to induce a temporary increase in their cell membrane permeability. High-resolution transmission electron microscopy (TEM) confirmed cell membrane permeabilization via visualisation of the translocation of silica nanospheres (d = 23.5 ± 0.2 nm) and their clusters (d = 63 nm) into the PC 12 cells. Analysis of scanning electron microscopy (SEM) micrographs revealed the formation of atypically large (up to 1 µm) blebs on the surface of PC 12 cells when exposed to THz radiation. Long-term analysis showed no substantial differences in metabolic activity between the PC 12 cells exposed to THz radiation and untreated cells; however, a higher population of the THz-treated PC 12 cells responded to the nerve growth factor (NGF) by extending longer neurites (up to 0–20 µm) compared to the untreated PC12 cells (up to 20 µm). These findings present implications for the development of nanoparticle-mediated drug delivery and gene therapy strategies since THz irradiation can promote nanoparticle uptake by cells without causing apoptosis, necrosis or physiological damage, as well as provide a deeper fundamental insight into the biological effects of environmental exposure of cells to electromagnetic radiation of super high frequencies.

scholarly journals Multi-Pharmacology of Berberine in Atherosclerosis and Metabolic Diseases: Potential Contribution of Gut Microbiota

2021 ◽  
Vol 12 ◽  
Author(s):  
Shengjie Yang ◽  
Dan Li ◽  
Zongliang Yu ◽  
Yujuan Li ◽  
Min Wu
Keyword(s):  
Gut Microbiota ◽  
Energy Homeostasis ◽  
Metabolic Diseases ◽  
Biological Effects ◽  
Intestinal Barrier ◽  
Isoquinoline Alkaloid ◽  
Research Progress ◽  
Intestinal Barrier Function ◽  
Potential Contribution ◽  
Nonalcoholic Fatty Liver

Atherosclerosis (AS), especially atherosclerotic cardiovascular diseases (ASCVDs), and metabolic diseases (such as diabetes, obesity, dyslipidemia, and nonalcoholic fatty liver disease) are major public health issues worldwide that seriously threaten human health. Exploring effective natural product-based drugs is a promising strategy for the treatment of AS and metabolic diseases. Berberine (BBR), an important isoquinoline alkaloid found in various medicinal plants, has been shown to have multiple pharmacological effects and therapeutic applications. In view of its low bioavailability, increasing evidence indicates that the gut microbiota may serve as a target for the multifunctional effects of BBR. Under the pathological conditions of AS and metabolic diseases, BBR improves intestinal barrier function and reduces inflammation induced by gut microbiota-derived lipopolysaccharide (LPS). Moreover, BBR reverses or induces structural and compositional alterations in the gut microbiota and regulates gut microbe-dependent metabolites as well as related downstream pathways; this improves glucose and lipid metabolism and energy homeostasis. These findings at least partly explain the effect of BBR on AS and metabolic diseases. In this review, we elaborate on the research progress of BBR and its mechanisms of action in the treatment of AS and metabolic diseases from the perspective of gut microbiota, to reveal the potential contribution of gut microbiota to the multifunctional biological effects of BBR.

scholarly journals Research Progress on the Biological Effects of Low-Dose Radiation in China

Dose-Response ◽  
2019 ◽  
Vol 17 (1) ◽  
pp. 155932581983348 ◽  
Author(s):  
Kaihua Ji ◽  
Yan Wang ◽  
Liqing Du ◽  
Chang Xu ◽  
Yang Liu ◽  
...  
Keyword(s):  
Low Dose ◽  
Biological Effects ◽  
Research Progress ◽  
Low Dose Radiation ◽  
Dose Radiation
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