scholarly journals TLR4 AND PI3K/AKT PATHWAY ACTIVATION: NEW APPROACH FOR CANCER DETECTION

2011 ◽  
Vol 2 (6) ◽  
Author(s):  
Dugeshwar Karley ◽  
Archana Tiwari ◽  
Deepesh Gupta
Keyword(s):  
Cancer Detection ◽  
Akt Pathway ◽  
New Approach ◽  
Pathway Activation

Phosphatidylinositol 3-Kinase/AKT Pathway Activation in Human Vestibular Schwannoma

2008 ◽  
Vol 29 (1) ◽  
pp. 58-68 ◽  
Author(s):  
Abraham Jacob ◽  
Tina X. Lee ◽  
Brian A. Neff ◽  
Shyra Miller ◽  
Bradley Welling ◽  
...  
Keyword(s):  
Vestibular Schwannoma ◽  
Akt Pathway ◽  
Phosphatidylinositol 3 Kinase ◽  
Pathway Activation ◽  
Phosphatidylinositol 3

scholarly journals Alternative HER/PTEN/Akt Pathway Activation in HPV Positive and Negative Penile Carcinomas

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e17517 ◽  
Author(s):  
Elzbieta Stankiewicz ◽  
David M. Prowse ◽  
Mansum Ng ◽  
Jack Cuzick ◽  
David Mesher ◽  
...  
Keyword(s):  
Akt Pathway ◽  
Pathway Activation

scholarly journals The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation

2018 ◽  
Vol 9 (2) ◽  
Author(s):  
Qiong Wu ◽  
Jin-xian Chen ◽  
Yu Chen ◽  
Li-li Cai ◽  
Xiao-zhong Wang ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Akt Pathway ◽  
Pathway Activation

Evaluation of diagnostic accuracy in free-response detection-localization tasks using ROC tools

2018 ◽  
Vol 28 (6) ◽  
pp. 1808-1825 ◽  
Author(s):  
Andriy I Bandos ◽  
Nancy A Obuchowski
Keyword(s):  
Cancer Detection ◽  
Roc Analysis ◽  
Operating Characteristic ◽  
Roc Curves ◽  
Design Parameters ◽  
Diagnostic Systems ◽  
Free Response ◽  
New Approach ◽  
Alternative Approaches ◽  
Response Detection

Diagnostic systems designed to detect possibly multiple lesions per patient (e.g. multiple polyps during CT colonoscopy) are often evaluated in “free-response” studies that allow for diagnostic responses unconstrained in their number and locations. Analysis of free-response studies requires extensions of the traditional receiver operating characteristic (ROC) analysis, which are termed free-response ROC (FROC) methodology. Despite substantial developments in this area, FROC tools and approaches are much more cumbersome than traditional ROC methods. Alternative approaches that use well-known ROC tools (e.g. ROI-ROC) require defining and physically delineating regions of interest (ROI) and combine FROC data within ROIs. We propose an approach that allows analyzing FROC data using conventional ROC tools without delineating the actual ROIs or reducing data. The design parameters of FROC study are used to make FROC data analyzable using ROC tools and to calibrate the corresponding FROC and ROC curves on both conceptual and numerical levels. Differences in the performance indices of the nonparametric FROC and the new approach are shown to be asymptotically negligible and typically rather small in practice. Data from a large multi-reader study of colon cancer detection are used to illustrate the new approach.

scholarly journals PD‐L1 promotes OCT4 and Nanog expression in breast cancer stem cells by sustaining PI3K/AKT pathway activation

2017 ◽  
Vol 141 (7) ◽  
pp. 1402-1412 ◽  
Author(s):  
Sheema Almozyan ◽  
Dilek Colak ◽  
Fatmah Mansour ◽  
Ayodele Alaiya ◽  
Olfat Al‐Harazi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Akt Pathway ◽  
Breast Cancer Stem Cells ◽  
Nanog Expression ◽  
Pathway Activation

Sa1793 Cooperation Between Antagonists of Constitutive Wnt/ß-Catenin and MAPK or PI3K/AKT Pathway Activation in Pancreatic Adenocarcinomas

2012 ◽  
Vol 142 (5) ◽  
pp. S-327
Author(s):  
Stefania Asciutti ◽  
Gal Akiri ◽  
Sapna Vijayakumar ◽  
Luca Grumolato ◽  
Phyllus Mong ◽  
...  
Keyword(s):  
Akt Pathway ◽  
Pathway Activation
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