scholarly journals Differential Muscle Hypertrophy Is Associated with Satellite Cell Numbers and Akt Pathway Activation Following Activin Type IIB Receptor Inhibition in Mtm1 p.R69C Mice

2014 ◽  
Vol 184 (6) ◽  
pp. 1831-1842 ◽  
Author(s):  
Michael W. Lawlor ◽  
Marissa G. Viola ◽  
Hui Meng ◽  
Rachel V. Edelstein ◽  
Fujun Liu ◽  
...  
Keyword(s):  
Satellite Cell ◽  
Muscle Hypertrophy ◽  
Akt Pathway ◽  
Cell Numbers ◽  
Receptor Inhibition ◽  
Pathway Activation

Phosphatidylinositol 3-Kinase/AKT Pathway Activation in Human Vestibular Schwannoma

2008 ◽  
Vol 29 (1) ◽  
pp. 58-68 ◽  
Author(s):  
Abraham Jacob ◽  
Tina X. Lee ◽  
Brian A. Neff ◽  
Shyra Miller ◽  
Bradley Welling ◽  
...  
Keyword(s):  
Vestibular Schwannoma ◽  
Akt Pathway ◽  
Phosphatidylinositol 3 Kinase ◽  
Pathway Activation ◽  
Phosphatidylinositol 3

scholarly journals Alternative HER/PTEN/Akt Pathway Activation in HPV Positive and Negative Penile Carcinomas

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e17517 ◽  
Author(s):  
Elzbieta Stankiewicz ◽  
David M. Prowse ◽  
Mansum Ng ◽  
Jack Cuzick ◽  
David Mesher ◽  
...  
Keyword(s):  
Akt Pathway ◽  
Pathway Activation

scholarly journals The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation

2018 ◽  
Vol 9 (2) ◽  
Author(s):  
Qiong Wu ◽  
Jin-xian Chen ◽  
Yu Chen ◽  
Li-li Cai ◽  
Xiao-zhong Wang ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Akt Pathway ◽  
Pathway Activation

scholarly journals Methodological issues limit interpretation of negative effects of satellite cell depletion on adult muscle hypertrophy

Development ◽  
2017 ◽  
Vol 144 (8) ◽  
pp. 1363-1365 ◽  
Author(s):  
John J. McCarthy ◽  
Esther E. Dupont-Versteegden ◽  
Christopher S. Fry ◽  
Kevin A. Murach ◽  
Charlotte A. Peterson
Keyword(s):  
Satellite Cell ◽  
Muscle Hypertrophy ◽  
Cell Depletion ◽  
Methodological Issues ◽  
Negative Effects ◽  
Adult Muscle

scholarly journals Akt1 deficiency diminishes skeletal muscle hypertrophy by reducing satellite cell proliferation

2018 ◽  
Vol 314 (5) ◽  
pp. R741-R751 ◽  
Author(s):  
Nobuki Moriya ◽  
Mitsunori Miyazaki
Keyword(s):  
Skeletal Muscle ◽  
Cell Proliferation ◽  
Protein Synthesis ◽  
Satellite Cell ◽  
Muscle Mass ◽  
Satellite Cells ◽  
Muscle Hypertrophy ◽  
Mtor Signaling ◽  
Skeletal Muscle Hypertrophy ◽  
Satellite Cell Proliferation

Skeletal muscle mass is determined by the net dynamic balance between protein synthesis and degradation. Although the Akt/mechanistic target of rapamycin (mTOR)-dependent pathway plays an important role in promoting protein synthesis and subsequent skeletal muscle hypertrophy, the precise molecular regulation of mTOR activity by the upstream protein kinase Akt is largely unknown. In addition, the activation of satellite cells has been indicated as a key regulator of muscle mass. However, the requirement of satellite cells for load-induced skeletal muscle hypertrophy is still under intense debate. In this study, female germline Akt1 knockout (KO) mice were used to examine whether Akt1 deficiency attenuates load-induced skeletal muscle hypertrophy through suppressing mTOR-dependent signaling and satellite cell proliferation. Akt1 KO mice showed a blunted hypertrophic response of skeletal muscle, with a diminished rate of satellite cell proliferation following mechanical overload. In contrast, Akt1 deficiency did not affect the load-induced activation of mTOR signaling and the subsequent enhanced rate of protein synthesis in skeletal muscle. These observations suggest that the load-induced activation of mTOR signaling occurs independently of Akt1 regulation and that Akt1 plays a critical role in regulating satellite cell proliferation during load-induced muscle hypertrophy.

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