scholarly journals Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study

2021 ◽  
Author(s):  
Ashley Kieran Clift ◽  
Defne Saatci ◽  
Carol A.C. Coupland ◽  
Hajira Dambha-Miller ◽  
Julia Hippisley-Cox ◽  
...  
Keyword(s):  
Cohort Study ◽  
Sickle Cell ◽  
Sickle Cell Disorders

Retrospective Cohort Study Comparing the Effect of Obesity in Children with Sickle Cell Disease

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 264A-264A
Author(s):  
Parth J. Bhatt ◽  
Dinesh Singh ◽  
Akingbola Olubenga ◽  
Devraj Chavda ◽  
Achint Patel
Keyword(s):  
Cohort Study ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Cell Disease ◽  
Obesity In Children

Fluorescence spectroscopy as a novel technique for premarital screening of sickle cell disorders

2021 ◽  
pp. 102276
Author(s):  
Sandhanasamy Devanesan ◽  
Mohamad S. AlSalhi ◽  
Vadivel Masilamani ◽  
Fathima AlQatahny ◽  
Aruliah Rajasekar ◽  
...  
Keyword(s):  
Fluorescence Spectroscopy ◽  
Sickle Cell ◽  
Novel Technique ◽  
Premarital Screening ◽  
Sickle Cell Disorders

Generalization of a genetic risk score for time to first albuminuria in children with sickle cell anaemia: SCCRIP cohort study results

2021 ◽  
Author(s):  
Sara R. Rashkin ◽  
Evadnie Rampersaud ◽  
Guolian Kang ◽  
Kenneth I. Ataga ◽  
Jane S. Hankins ◽  
...  
Keyword(s):  
Cohort Study ◽  
Sickle Cell ◽  
Risk Score ◽  
Genetic Risk ◽  
Sickle Cell Anaemia ◽  
Genetic Risk Score ◽  
Study Results

scholarly journals Morbidity and mortality of sickle cell disease patients starting intermittent haemodialysis: a comparative cohort study with non- Sickle dialysis patients

2016 ◽  
Vol 174 (1) ◽  
pp. 148-152 ◽  
Author(s):  
Louise Nielsen ◽  
Florence Canouï-Poitrine ◽  
Jean-Philippe Jais ◽  
Djamal Dahmane ◽  
Pablo Bartolucci ◽  
...  
Keyword(s):  
Cohort Study ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Morbidity And Mortality ◽  
Cell Disease ◽  
Dialysis Patients ◽  
Intermittent Haemodialysis ◽  
Comparative Cohort Study

Developmental Pattern of Splenic Dysfunction in Sickle Cell Disorders

PEDIATRICS ◽  
1985 ◽  
Vol 76 (3) ◽  
pp. 392-397
Author(s):  
Howard A. Pearson ◽  
Diane Gallagher ◽  
Robert Chilcote ◽  
Edmund Sullivan ◽  
Judith Wilimas ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Bacterial Infections ◽  
Fetal Hemoglobin ◽  
Developmental Pattern ◽  
Cross Sectional ◽  
Serial Measurement ◽  
Hemoglobin C ◽  
Sickle Cell Disorders ◽  
Sectional Analysis

Splenic function in sickle hemoglobinopathy syndromes was assessed to determine the developmental pattern of splenic dysfunction. Nonvisualization of the spleen using technetium-99 metastable (99mTc) spleen scans correlated strongly with pocked (vesiculated) RBCs ≥3.5%. Cross-sectional analysis of pocked RBC data from 2,086 patients showed differences in the developmental pattern of splenic dysfunction between several disorders. In hemoglobin SS disease (sickle cell anemia) and hemoglobin Sβ° thalassemia, splenic dysfunction (≥3.5% pocked RBCs) often occurred in the first 6 to 12 months of life. In hemoglobin Sβ+ thalassemia, splenic dysfunction occurred less frequently and later. Splenic dysfunction in hemoglobin SC disease (sickle cell-hemoglobin C) was intermediate. The level of pocked RBCs was inversely associated with fetal hemoglobin (P < .007) and directly associated with age (P ≤ .001). These patterns of splenic dysfunction reflect the known severity of hemolysis and intravascular sickling and are consistent with the epidemiology of severe bacterial meningitis and sepsis in these diseases. Serial measurement of pocked RBCs permits determination of the onset of splenic dysfunction and the time of increased susceptibility to severe bacterial infections.

scholarly journals Comparison of Actual with Estimated Weight and Height in Children with Sickle Cell Anaemia in Lagos, Nigeria

2019 ◽  
Vol 2 (4) ◽  
pp. 185-190
Author(s):  
SO Akodu ◽  
AF Adekanmbi ◽  
AT Ogunlesi
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Genetic Disorders ◽  
Actual Length ◽  
Mean Values ◽  
Standard Methods ◽  
Positive Linear Relationship ◽  
Measured Weight ◽  
Sickle Cell Disorders ◽  
Paediatric Practice

Sickle cell disorders are the most common genetic disorders worldwide as well as in Nigeria. The weight and height are the most used anthropometric measurements in paediatric practice for the calculation of many parameters. The objective is to determine the reliability of weight and height estimates among children with sickle cell anaemia compared with measured weight and height. A random sample of SCA children aged eight months to 12 years was studied. Height and weight were measured using standard methods, while BMI was estimated using kg/m2. These were compared with estimated weight, height and BMI. Five subjects were adjudged obese using estimated BMI: three of these five subjects were identified as obese using actual BMI. Regression analysis showed that there appears to be more positive linear relationship for weight and length/height among children aged 1– 6 years. The measured mean weight and BMI were significantly lower than the estimated mean values. The overall mean of estimated length/height did not differ significantly from overall mean of the actual length/height. In comparison with the actual BMI, the estimated BMI did not identify any of the subjects with either thinness or overweight while children with obesity were over-estimated. The formula methods of estimating weights and heights for the various ages in children with sickle cell anaemia are over-estimating their actual values; this is more obvious for weight.

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