Comparison of Actual with Estimated Weight and Height in Children with Sickle Cell Anaemia in Lagos, Nigeria

SO Akodu; AF Adekanmbi; AT Ogunlesi

doi:10.46912/2i4.2019126

Comparison of Actual with Estimated Weight and Height in Children with Sickle Cell Anaemia in Lagos, Nigeria

Journal of BioMedical Research and Clinical Practice ◽

10.46912/jbrcp.126 ◽

2019 ◽

Vol 2 (4) ◽

pp. 185-190

Author(s):

SO Akodu ◽

AF Adekanmbi ◽

AT Ogunlesi

Keyword(s):

Sickle Cell ◽

Sickle Cell Anaemia ◽

Genetic Disorders ◽

Actual Length ◽

Mean Values ◽

Standard Methods ◽

Positive Linear Relationship ◽

Measured Weight ◽

Sickle Cell Disorders ◽

Paediatric Practice

Sickle cell disorders are the most common genetic disorders worldwide as well as in Nigeria. The weight and height are the most used anthropometric measurements in paediatric practice for the calculation of many parameters. The objective is to determine the reliability of weight and height estimates among children with sickle cell anaemia compared with measured weight and height. A random sample of SCA children aged eight months to 12 years was studied. Height and weight were measured using standard methods, while BMI was estimated using kg/m2. These were compared with estimated weight, height and BMI. Five subjects were adjudged obese using estimated BMI: three of these five subjects were identified as obese using actual BMI. Regression analysis showed that there appears to be more positive linear relationship for weight and length/height among children aged 1– 6 years. The measured mean weight and BMI were significantly lower than the estimated mean values. The overall mean of estimated length/height did not differ significantly from overall mean of the actual length/height. In comparison with the actual BMI, the estimated BMI did not identify any of the subjects with either thinness or overweight while children with obesity were over-estimated. The formula methods of estimating weights and heights for the various ages in children with sickle cell anaemia are over-estimating their actual values; this is more obvious for weight.

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Comparison of Actual with Estimated Weight and Height in Children with Sickle Cell Anaemia in Lagos, Nigeria

Journal of BioMedical Research and Clinical Practice ◽

10.46912/jbrcp2i4.2019126 ◽

2019 ◽

Vol 2 (4) ◽

pp. 185-190

Author(s):

SO Akodu ◽

AF Adekanmbi ◽

AT Ogunlesi

Keyword(s):

Sickle Cell ◽

Sickle Cell Anaemia ◽

Genetic Disorders ◽

Actual Length ◽

Mean Values ◽

Standard Methods ◽

Positive Linear Relationship ◽

Measured Weight ◽

Sickle Cell Disorders ◽

Paediatric Practice

Sickle cell disorders are the most common genetic disorders worldwide as well as in Nigeria. The weight and height are the most used anthropometric measurements in paediatric practice for the calculation of many parameters. The objective is to determine the reliability of weight and height estimates among children with sickle cell anaemia compared with measured weight and height. A random sample of SCA children aged eight months to 12 years was studied. Height and weight were measured using standard methods, while BMI was estimated using kg/m2. These were compared with estimated weight, height and BMI. Five subjects were adjudged obese using estimated BMI: three of these five subjects were identified as obese using actual BMI. Regression analysis showed that there appears to be more positive linear relationship for weight and length/height among children aged 1– 6 years. The measured mean weight and BMI were significantly lower than the estimated mean values. The overall mean of estimated length/height did not differ significantly from overall mean of the actual length/height. In comparison with the actual BMI, the estimated BMI did not identify any of the subjects with either thinness or overweight while children with obesity were over-estimated. The formula methods of estimating weights and heights for the various ages in children with sickle cell anaemia are over-estimating their actual values; this is more obvious for weight.

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Comparison of Actual with Estimated Weight and Height in Children with Sickle Cell Anaemia in Lagos, Nigeria

Journal of BioMedical Research and Clinical Practice ◽

10.46912/jbrcp.v2i42019.126 ◽

2019 ◽

Vol 2 (4) ◽

pp. 185-190

Author(s):

SO Akodu ◽

AF Adekanmbi ◽

AT Ogunlesi

Keyword(s):

Sickle Cell ◽

Sickle Cell Anaemia ◽

Genetic Disorders ◽

Actual Length ◽

Mean Values ◽

Standard Methods ◽

Positive Linear Relationship ◽

Measured Weight ◽

Sickle Cell Disorders ◽

Paediatric Practice

Sickle cell disorders are the most common genetic disorders worldwide as well as in Nigeria. The weight and height are the most used anthropometric measurements in paediatric practice for the calculation of many parameters. The objective is to determine the reliability of weight and height estimates among children with sickle cell anaemia compared with measured weight and height. A random sample of SCA children aged eight months to 12 years was studied. Height and weight were measured using standard methods, while BMI was estimated using kg/m2. These were compared with estimated weight, height and BMI. Five subjects were adjudged obese using estimated BMI: three of these five subjects were identified as obese using actual BMI. Regression analysis showed that there appears to be more positive linear relationship for weight and length/height among children aged 1– 6 years. The measured mean weight and BMI were significantly lower than the estimated mean values. The overall mean of estimated length/height did not differ significantly from overall mean of the actual length/height. In comparison with the actual BMI, the estimated BMI did not identify any of the subjects with either thinness or overweight while children with obesity were over-estimated. The formula methods of estimating weights and heights for the various ages in children with sickle cell anaemia are over-estimating their actual values; this is more obvious for weight.

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Comparison of Actual with Estimated Weight and Height in Children with Sickle Cell Anaemia in Lagos, Nigeria

Journal of BioMedical Research and Clinical Practice ◽

10.46912/jbrcp.v2.i4.2019.126 ◽

2019 ◽

Vol 2 (4) ◽

pp. 185-190

Author(s):

SO Akodu ◽

AF Adekanmbi ◽

AT Ogunlesi

Keyword(s):

Sickle Cell ◽

Sickle Cell Anaemia ◽

Genetic Disorders ◽

Actual Length ◽

Mean Values ◽

Standard Methods ◽

Positive Linear Relationship ◽

Measured Weight ◽

Sickle Cell Disorders ◽

Paediatric Practice

Sickle cell disorders are the most common genetic disorders worldwide as well as in Nigeria. The weight and height are the most used anthropometric measurements in paediatric practice for the calculation of many parameters. The objective is to determine the reliability of weight and height estimates among children with sickle cell anaemia compared with measured weight and height. A random sample of SCA children aged eight months to 12 years was studied. Height and weight were measured using standard methods, while BMI was estimated using kg/m2. These were compared with estimated weight, height and BMI. Five subjects were adjudged obese using estimated BMI: three of these five subjects were identified as obese using actual BMI. Regression analysis showed that there appears to be more positive linear relationship for weight and length/height among children aged 1– 6 years. The measured mean weight and BMI were significantly lower than the estimated mean values. The overall mean of estimated length/height did not differ significantly from overall mean of the actual length/height. In comparison with the actual BMI, the estimated BMI did not identify any of the subjects with either thinness or overweight while children with obesity were over-estimated. The formula methods of estimating weights and heights for the various ages in children with sickle cell anaemia are over-estimating their actual values; this is more obvious for weight.

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A study of HPLC patterns in patients of sickle cell anemia with analysis of red cell parameters

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20182823 ◽

2018 ◽

Vol 6 (7) ◽

pp. 2390

Author(s):

Ashish Jawarkar ◽

Varsha Bhatia

Keyword(s):

Sickle Cell Disease ◽

Sickle Cell ◽

Sickle Cell Trait ◽

Genetic Disorders ◽

Cell Disease ◽

Cell Parameters ◽

Rbc Indices ◽

Sickle Cell Disorders ◽

Low Levels ◽

High Index Of Suspicion

Background: Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS). In this study we want to profile various types of haemoglobins and their relative percentage in sickle cell cases. Also, we will analyse RBC indices such as Hb, HCT, MCV, MCH, MCHC and RDW-CV.Methods: We analysed blood from 200 patients suspected to have Sickle cell hemoglobinopathies and subjected it to Sickling screening test. All positive cases will be subjected to HPLC to separate constituent haemoglobins and CBC analysis was done to check RBC indices.Results: In sickle cell trait (SCT) patients, there is a significantly higher level of HbA2 and HbS and significantly lower level of HbA. In sickle cell disease patients, there were significantly higher levels of HbA2, HbF and HbS and significantly lower levels of HbA. Both sickle cell trait and sickle cell disease patients had significantly lower levels of haematocrit, MCH and higher RDW CV.Conclusions: While analysing HPLC patterns, appearance of HbS, low levels of HbA and high levels of HbF and HbA2 should raise a suspicion for presence of Sickle cell hemoglobinopathy. There was statistical difference in levels of Hb, HCT, MCH and RDW-CV between cases and controls. High index of suspicion should be maintained when these parameters are on lower side, especially in population who is prone to have sickle cell disorders.

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Screening of Hemoglobin disorder in non-endemic region

Journal of Pathology of Nepal ◽

10.3126/jpn.v7i2.18104 ◽

2017 ◽

Vol 7 (2) ◽

Author(s):

Shiva Raj K.C.

Keyword(s):

At Risk ◽

Sickle Cell ◽

Sickle Cell Anemia ◽

Genetic Disorders ◽

Deficiency Anemia ◽

Healthy Children ◽

Endemic Region ◽

Inherited Disorders ◽

Birth Prevalence ◽

Sickle Cell Disorders

Hemoglobinopathies are group of inherited disorders which can broadly be classified into qualitative and quantitative defects. Qualitative defects include Sickle cell anemia whereas quantitative defect includes Thalassemia. Sickle cell anemia is characterised by abnormality in the structure of haemoglobin in particular substitution of adenine in sixth codon of β gene (GAG-GTG), thereby encoding valine instead of glutamic acid in sixth position of β chain.1 In thalassemia there is reduced production of one or more globin chains. Thalassemia is generally classified into two broad categories: α-thalassemia and β-thalassemia usually caused by deletions of one or all four alleles of α- genes and point mutation β gene respectively. This results in reduction or absence in globin chain synthesis.Hemoglobinopathies can be either in trait or disease condition. People with traits do not require medical or follow-up care after the initial diagnosis is made. People with β-thalassemia trait should be warned that their condition can be misdiagnosed as the more common iron deficiency anemia and should avoid routine use of iron supplements. Counselling is indicated in all persons with genetic disorders, especially when the family is at risk of a severe form of disease that may be prevented.In Nepal, though actual data is not available, increased incidence of hemoglobinopathies is observed among the ethnic community of Terai region. As we know, inherited haemoglobin disorders (sickle-cell disorders and thalassaemias) were originally characteristic of the tropics and subtropics. However, due to migration it has become common worldwide.2-5 In Nepal; hemoglobinopathies are seen in other population than from Terai. Hemoglobinopathies can be controlled cost-effectively by programmes that integrate treatment with carrier detection and genetic counselling, WHO has recommended global development of these services.5 A policy of detecting carriers and informing them of their risk, and possibilities for reducing it, usually leads to a fall in births and deaths of affected children. Requirements are the same for thalassaemias and sickle-cell disorders. To prevent and minimize the disease regular screening; in all the communities; should be conducted at least in anaemic individuals with microcytic hypochromic anaema. Population screening is not the only useful strategy: family studies can be cost-effective.The effects of screening depend on the choices made by informed individuals. Birth prevalence of thalassaemia can fall by over 90%6,7 because most at-risk couples limit their family to two healthy children,6,7 there is very high uptake of prenatal diagnosis, and some carriers avoid risk by selecting a non-carrier partner.6,7 Available data for sickle-cell disorders shows lower use of prenatal diagnosis8 and improved survival of affected children with neonatal diagnosis.

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The morbidity pattern of children with sickle cell disorders admitted to the Queen Elizabeth Hospital, Barbados (2009–2013)

Tropical Doctor ◽

10.1177/0049475517740309 ◽

2017 ◽

Vol 48 (1) ◽

pp. 11-16 ◽

Cited By ~ 1

Author(s):

D Grannum ◽

Paula M Lashley

Keyword(s):

Retrospective Study ◽

Sickle Cell ◽

Universal Screening ◽

Sickle Cell Anaemia ◽

Queen Elizabeth Hospital ◽

Blood Transfusions ◽

Comprehensive Management ◽

Sickle Cell Disorders ◽

The Caribbean ◽

Reason For Admission

A retrospective study was conducted by examining all the medical files of all the children with sickle cell anaemia (Hb SS) admitted from 1 January 2009 to 31 December 2013. A total of 220 admission notes (59 patients aged 5 months–16 years) were analysed. Of these, 53.2% were boys; 85.8% of the patients had Hb SS. The most common reason for admission was vaso-occlusive crisis. Blood transfusions were used in 39.7% of admissions There were no deaths during the study period. We note the number of sickle cell-related admissions and morbidity has increased, along with an increase in the number of blood transfusions. The mortality rate for children with sickle cell in Barbados is low compared to other territories in the Caribbean and worldwide. The need for better comprehensive management protocols and universal screening should decrease the morbidity patterns seen in this study.

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Cormic Index Profile of Children with Sickle Cell Anaemia in Lagos, Nigeria

Anemia ◽

10.1155/2014/312302 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6

Author(s):

Samuel Olufemi Akodu ◽

Olisamedua Fidelis Njokanma ◽

Omolara Adeolu Kehinde

Keyword(s):

Sickle Cell ◽

Sickle Cell Anaemia ◽

Negative Relationship ◽

Significant Negative Correlation ◽

Full Length ◽

Leg Length ◽

Sitting Height ◽

Significant Negative Relationship ◽

Negative Effect ◽

Sickle Cell Disorders

Background. Sickle cell disorders are known to have a negative effect on linear growth. This could potentially affect proportional growth and, hence, Cormic Index.Objective. To determine the Cormic Index in the sickle cell anaemia population in Lagos.Methodology. A consecutive sample of 100 children with haemoglobin genotype SS, aged eight months to 15 years, and 100 age and sex matched controls (haemoglobin genotype AA) was studied. Sitting height (upper segment) and full length or height were measured. Sitting height was then expressed as a percentage of full length/height (Cormic Index).Results. The mean Cormic Index decreased with age among primary subjects (SS) and AA controls. The overall mean Cormic Index among primary subjects was comparable to that of controls (55.0±4.6% versus54.5±5.2%;54.8±4.5% versus53.6±4.9%) in boys and girls, respectively. In comparison with AA controls, female children with sickle cell anaemia who were older than 10 years had a significantly lower mean Cormic Index.Conclusion. There was a significant negative relationship between Cormic Index and height in subjects and controls irrespective of gender. Similarly, a significant negative correlation existed between age, sitting height, subischial leg length, weight, and Cormic Index in both subjects and controls.

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