scholarly journals Synergistic Study on n-Hexane Extract of Anredera cordifolia (Ten.)v Steenis (binahong) Leaves Combined with Antituberculosis Drugs against Drug-Sensitive and Drug-Resistant of Mycobacterium tuberculosis

2018 ◽  
pp. 134-138
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Hexane Extract ◽  
Drug Resistant ◽  
Antituberculosis Drugs

Mycobacterium tuberculosis topoisomerases and EthR as the targets for new anti-TB drugs development

2019 ◽  
Vol 11 (16) ◽  
pp. 2193-2203
Author(s):  
Rafal Sawicki ◽  
Grazyna Ginalska
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Short Review ◽  
Drug Resistant ◽  
Dna Topoisomerases ◽  
Antituberculosis Drugs ◽  
Drug Candidates ◽  
Computational Sciences ◽  
Resistant Strains ◽  
Drug Resistant Strains ◽  
New Strategies

The significant increase in the detection of drug-resistant strains of Mycobacterium tuberculosis caused an urgent need for the discovery new antituberculosis drugs. Development of bioinformatics and computational sciences enabled the progress of new strategies leading to design, discovery and identification of a series of interesting drug candidates. In this short review, we would like to present recently discovered compounds targeting important mycobacterial proteins: DNA topoisomerases and the transcriptional repressor of EthA monooxygenase – EthR.

A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs

Tuberculosis ◽  
2018 ◽  
Vol 108 ◽  
pp. 64-69 ◽  
Author(s):  
Ratikorn Gamngoen ◽  
Chanyanuch Putim ◽  
Parichat Salee ◽  
Ponrut Phunpae ◽  
Bordin Butr-Indr
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Drug Resistant ◽  
First Line ◽  
Antituberculosis Drugs

scholarly journals Antiprotozoal and Antimycobacterial Activities of Pure Compounds fromAristolochia elegansRhizomes

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Adelina Jiménez-Arellanes ◽  
Rosalba León-Díaz ◽  
Mariana Meckes ◽  
Amparo Tapia ◽  
Gloria María Molina-Salinas ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Clinical Isolate ◽  
Antimycobacterial Activity ◽  
Hexane Extract ◽  
Drug Resistant ◽  
Pure Compounds ◽  
Important Activity

We analyzed the antimycobacterial activity of the hexane extract of rhizomes fromAristolochia elegans. Some compounds of this extract were purified and tested against a group of drug-resistantMycobacterium tuberculosisstrains. We also evaluated their antiprotozoal activities. The hexane extract was active againstM. tuberculosisH37Rv at aMIC=100 μg mL−1; the pure compounds eupomatenoid-1, fargesin, and (8R,8′R,9R)-cubebin were active againstM. tuberculosisH37Rv (MIC = 50 μg mL−1), while fargesin presented activity against three monoresistant strains ofM. tuberculosisH37Rv and a MDR clinical isolate ofM. tuberculosis(MIC<50 μg mL-1). Both the extract and eupomatenoid-1 were very active againstE. histolyticaandG. lamblia(IC50<0.624 μg mL-1); in contrast, fargesin and (8R,8′R,9R)-cubebin were moderately active (IC50<275 μg mL-1). In this context, two compounds responsible for the antimycobacterial presented byA. elegansare fargesin and cubebin, although others may exert this activity also. In addition to the antimycobacterial activity, the hexane extract has important activity againstE. histolyticaandG. lamblia, and eupomatenoid-1 is one of the compounds responsible for the antiparasite activity.

scholarly journals Analysis of drug resistance and mutation profiles in Mycobacterium tuberculosis isolates in a surveillance site in Beijing, China

2021 ◽  
Vol 49 (1) ◽  
pp. 030006052098493
Author(s):  
Jie Zhang ◽  
Yixuan Ren ◽  
Liping Pan ◽  
Junli Yi ◽  
Tong Guan ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Drug Testing ◽  
Multidrug Resistant ◽  
High Rate ◽  
Drug Resistant ◽  
Surveillance Site ◽  
Mdr Tb ◽  
Previously Treated Patients ◽  
Beijing China

Objective This study analyzed drug resistance and mutations profiles in Mycobacterium tuberculosis isolates in a surveillance site in Huairou District, Beijing, China. Methods The proportion method was used to assess drug resistance profiles for four first-line and seven second-line anti-tuberculosis (TB) drugs. Molecular line probe assays were used for the rapid detection of resistance to rifampicin (RIF) and isoniazid (INH). Results Among 235 strains of M. tuberculosis, 79 (33.6%) isolates were resistant to one or more drugs. The isolates included 18 monoresistant (7.7%), 19 polyresistant (8.1%), 28 RIF-resistant (11.9%), 24 multidrug-resistant (MDR) (10.2%), 7 pre-extensively drug-resistant (XDR, 3.0%), and 2 XDR strains (0.9%). A higher rate of MDR-TB was detected among previously treated patients than among patients with newly diagnosed TB (34.5% vs. 6.8%). The majority (62.5%) of RIF-resistant isolates exhibited a mutation at S531L in the DNA-dependent RNA polymerase gene. Meanwhile, 62.9% of INH-resistant isolates carried a mutation at S315T1 in the katG gene. Conclusion Our results confirmed the high rate of drug-resistant TB, especially MDR-TB, in Huairou District, Beijing, China. Therefore, detailed drug testing is crucial in the evaluation of MDR-TB treatment.

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