scholarly journals Combination Effect of Antituberculosis Drugs and Ethanolic Extract of Selected Medicinal Plants against Multi-Drug Resistant Mycobacterium tuberculosis Isolates

2017 ◽  
Vol 85 (1) ◽  
pp. 14 ◽  
Author(s):  
Prabasiwi Nur Fauziyah ◽  
Elin Yulinah Sukandar ◽  
Dhyan Kusuma Ayuningtyas
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Medicinal Plants ◽  
Ethanolic Extract ◽  
Combination Effect ◽  
Drug Resistant ◽  
Antituberculosis Drugs

Mycobacterium tuberculosis topoisomerases and EthR as the targets for new anti-TB drugs development

2019 ◽  
Vol 11 (16) ◽  
pp. 2193-2203
Author(s):  
Rafal Sawicki ◽  
Grazyna Ginalska
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Short Review ◽  
Drug Resistant ◽  
Dna Topoisomerases ◽  
Antituberculosis Drugs ◽  
Drug Candidates ◽  
Computational Sciences ◽  
Resistant Strains ◽  
Drug Resistant Strains ◽  
New Strategies

The significant increase in the detection of drug-resistant strains of Mycobacterium tuberculosis caused an urgent need for the discovery new antituberculosis drugs. Development of bioinformatics and computational sciences enabled the progress of new strategies leading to design, discovery and identification of a series of interesting drug candidates. In this short review, we would like to present recently discovered compounds targeting important mycobacterial proteins: DNA topoisomerases and the transcriptional repressor of EthA monooxygenase – EthR.

Anti-mycobacterial Constituents from Medicinal Plants; A Review

2021 ◽  
Vol 21 ◽  
Author(s):  
Nandan Sarkar ◽  
Yadu Nandan Dey ◽  
Dharmendra Kumar ◽  
Mogana R
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Medicinal Plants ◽  
Development Process ◽  
Multidrug Resistant ◽  
Review Article ◽  
New Drugs ◽  
Drug Resistant ◽  
Drug Discovery And Development ◽  
Resistant Strains ◽  
Drug Resistant Strains

: Effective treatment of tuberculosis has been hindered by the emergence of drug-resistant strains of Mycobacterium therapeutic facilities tuberculosis. With the global resurgence of tuberculosis with the development of multidrug-resistant cases, there is a call for the development of new drugs to combat these diseases. Throughout history, natural products have afforded a rich source of compounds that have found many applications in the fields of medicine, pharmacy and biology, and continued to play a significant role in the drug discovery and development process. This review article depicts the various potential plant extracts as well as plant-derived phytoconstituents against the H37rv, the most persistent strains of Mycobacterium tuberculosis and its multidrug strains.

A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs

Tuberculosis ◽  
2018 ◽  
Vol 108 ◽  
pp. 64-69 ◽  
Author(s):  
Ratikorn Gamngoen ◽  
Chanyanuch Putim ◽  
Parichat Salee ◽  
Ponrut Phunpae ◽  
Bordin Butr-Indr
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Drug Resistant ◽  
First Line ◽  
Antituberculosis Drugs

scholarly journals Anti-tuberculosis Property of Various Extracts of Lannea against multi-drug resistant Mycobacterium tuberculosis

2020 ◽  
Vol 5 (1) ◽  
pp. 1-5
Author(s):  
Saravanakumar A ◽  
Gandhimathi R
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Medicinal Plants ◽  
Respiratory Tract ◽  
Aqueous Extracts ◽  
Drug Resistant ◽  
Human Beings ◽  
Pulmonary System ◽  
Infection And Inflammation ◽  
Upper Respiratory

Tuberculosis had been a stubborn disease that human beings are combating with from ages. It is a disease that affects the pulmonary system, basically the trachea and upper respiratory organs. It is caused by bacteria called Mycobacterium tuberculosis. Bacteria in the respiratory tract will cause infection and inflammation in the respiratory passages. It leads to narrowing and pain, which results in difficulty in breathing. There had been raising the confidence of the safety and potency of the herbs and medicinal plants. We have been using herbs to treat many diseases. The diseases that are caused primarily due to the viruses and bacteria are effectively treated using herbs in the traditional systems of medicine. One such plant is Lannea coramandelica which is proven to treat many diseases and is rich in polyphenols and flavonoids. The leaves of lannea were extracted using various solvents based on the polarity. It was then investigated for the anti-bacterial property against mycobacterium tuberculosis. All the extracts showed potency by inhibiting the bacteria, but Methanol and aqueous extracts showed a significantly better activity compared to the standard.

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