scholarly journals Sensitivity or resistance to steroid therapy in children with idiopathic nephrotic syndrome is not associated with polymorphism of angiotensin converting enzyme (ACE)

2016 ◽  
pp. 206-208
Author(s):  
Parisadat Ahmadi ◽  
Rozita Hoseini ◽  
Parvaneh Rahimi-moghaddam ◽  
Seyyed Ahmadi
Keyword(s):  
Nephrotic Syndrome ◽  
Angiotensin Converting Enzyme ◽  
Steroid Therapy ◽  
Idiopathic Nephrotic Syndrome ◽  
Converting Enzyme

scholarly journals Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis

2011 ◽  
Vol 12 (4) ◽  
pp. 601-610 ◽  
Author(s):  
Tian-Biao Zhou ◽  
Chao Ou ◽  
Yuan-Han Qin ◽  
Li-Na Su ◽  
Feng-Ying Lei ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Idiopathic Nephrotic Syndrome ◽  
Meta Analysis ◽  
Positive Association ◽  
Converting Enzyme ◽  
Positive Role ◽  
Different Populations ◽  
Search And Selection

Background and objective: Angiotensin converting enzyme (ACE) gene contains either an insertion (I) allele or a deletion (D) allele forming three potential genotypes: II, ID and DD. The D allele or DD genotype has been reported to be associated with higher plasma ACE level. An assessment of the association between ACE I/D gene polymorphism and idiopathic nephrotic syndrome (INS) susceptibility in children is still controversial. This meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and the onset of INS. Method: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases, and eligible investigations were synthesized using the meta-analysis method. Results: Nine investigations were identified for the analysis of association between ACE I/D gene polymorphism and INS risk in children, including six in Asians, one study for Caucasians and two for Africans. There was positive association between D allele or DD genotype and INS susceptibility in Asians (OR = 1.75, p = 0.01; OR = 2.01, p = 0.02), but not for Caucasian children and Africans (for Caucasians, D: OR=1.35, p = 0.27, DD: OR = 0.95, p = 0.91; for Africans, D: OR = 1.70, p = 0.56, DD: OR = 1.60, p = 0.73). Furthermore, II homozygous seemed to play a positive role against INS onset for Asians (OR = 0.59, p = 0.02), but the link between II genotype and INS risk was not observed in Caucasian children and Africans (Caucasians: OR = 0.31, p = 0.06; Africans: OR = 0.50, p = 0.59). Conclusions: D allele and DD homozygous might become significant genetic molecular markers for INS susceptibility in Asian children, but the association was not observed in Caucasians or Africans. However, the conclusion from our study cannot be sustained and more investigations on larger sample in different populations are required to further clarify the role of D allele or DD homozygous in the onset of INS in difference races.

Angiotensin-Converting Enzyme Gene Polymorphism in Children with Idiopathic Nephrotic Syndrome

2006 ◽  
Vol 26 (2) ◽  
pp. 157-162 ◽  
Author(s):  
I-Jung Tsai ◽  
Yao-Hsu Yang ◽  
Yen-Hung Lin ◽  
Vin-Cent Wu ◽  
Yong-Kwei Tsau ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Idiopathic Nephrotic Syndrome ◽  
Angiotensin Converting Enzyme Gene ◽  
Converting Enzyme ◽  
Enzyme Gene

scholarly journals The role of ACE inhibitor in reducing persistent proteinuria in nephrotic syndrome

2002 ◽  
Vol 42 (6) ◽  
pp. 243
Author(s):  
Erika Hutabarat ◽  
Husein Alatas ◽  
Sri Rezeki Hadinegoro
Keyword(s):  
Nephrotic Syndrome ◽  
Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Inhibitor ◽  
Enzyme Inhibitor ◽  
Mean Value ◽  
Converting Enzyme ◽  
Double Blind ◽  
Converting Enzyme Inhibitor ◽  
Persistent Proteinuria ◽  
End Stage

Background Patients with persistent proteinuria are at risk for progression to end-stage renal failure. Angiotensin converting enzyme inhibitor (ACEI) can decrease proteinuria in nephrotic syndrome (NS) patients with persistent proteinuria.Objective To evaluate the effectiveness of ACEI (enalapril) in reducing proteinuria in NS.Methods This study was conducted as a randomized double blind clinical trial with crossover design on persistent proteinuria NS patients who visited Cipto Mangunkusumo Hospital from December 2000 until July 2001. Twenty patients were enrolled in this study. Ten patients received enalapril 10 mg/day for 8 weeks and ten patients received placebo. Angiotensin converting enzyme inhibitor as considered effective if proteinuria was reduced for at least 50%.Results The patients aged between 2-16 years with a mean of 11.3 years and consisted of 16 boys and 4 girls with a ratio of 4:1. Urine protein and creatinine ratio (Up/Uc) was used to evaluate proteinuria. In the ACEI group, the mean value of proteinuria increasedtrom5.6 (95%CI 1.1 ;2.2)to 6.7 (95%CI 0.3;13.2) (p=0.721),  although it decreased in five patients. Decreased proteinuria to 50%or more was found in 2 out of 10 patients in the enalapril group while in the placebo group it was found in 3 out of 10, but this differences was not statistically significant (,0=0.5). Systolic blood pressure decreased significantly (p=0.0185) from 107 mmHg (95%CI 101.1;112.9 mmHg) to 103 mmHg (95%CI 96.2;109.8 mmHg) although still in nonnal range.Conclusions The efficacy of enalapril in reducing proteinuria could not be evaluated yet. A further study with greater sample and longer observation is needed.

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