Angiotensin-Converting Enzyme Genotype Is Not a Significant Genetic Risk Factor for Idiopathic Nephrotic Syndrome in Croatian Children

Nephron ◽  
2015 ◽  
Vol 130 (1) ◽  
pp. 29-34
Author(s):  
Danko Batinic ◽  
Jadranka Sertic ◽  
Marijana Coric ◽  
Pa�ko Konjevoda ◽  
Danica Batinic ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Risk Factor ◽  
Angiotensin Converting Enzyme ◽  
Genetic Risk ◽  
Idiopathic Nephrotic Syndrome ◽  
Genetic Risk Factor ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme Genotype

scholarly journals Deletion polymorphism in the angiotensin I converting enzyme (ACE) gene as a genetic risk factor for sarcoidosis.

Thorax ◽  
1996 ◽  
Vol 51 (8) ◽  
pp. 777-780 ◽  
Author(s):  
K. Furuya ◽  
E. Yamaguchi ◽  
A. Itoh ◽  
N. Hizawa ◽  
N. Ohnuma ◽  
...  
Keyword(s):  
Risk Factor ◽  
Genetic Risk ◽  
Genetic Risk Factor ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Deletion Polymorphism ◽  
Ace Gene ◽  
Angiotensin I Converting Enzyme

scholarly journals Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis

2011 ◽  
Vol 12 (4) ◽  
pp. 601-610 ◽  
Author(s):  
Tian-Biao Zhou ◽  
Chao Ou ◽  
Yuan-Han Qin ◽  
Li-Na Su ◽  
Feng-Ying Lei ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Idiopathic Nephrotic Syndrome ◽  
Meta Analysis ◽  
Positive Association ◽  
Converting Enzyme ◽  
Positive Role ◽  
Different Populations ◽  
Search And Selection

Background and objective: Angiotensin converting enzyme (ACE) gene contains either an insertion (I) allele or a deletion (D) allele forming three potential genotypes: II, ID and DD. The D allele or DD genotype has been reported to be associated with higher plasma ACE level. An assessment of the association between ACE I/D gene polymorphism and idiopathic nephrotic syndrome (INS) susceptibility in children is still controversial. This meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and the onset of INS. Method: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases, and eligible investigations were synthesized using the meta-analysis method. Results: Nine investigations were identified for the analysis of association between ACE I/D gene polymorphism and INS risk in children, including six in Asians, one study for Caucasians and two for Africans. There was positive association between D allele or DD genotype and INS susceptibility in Asians (OR = 1.75, p = 0.01; OR = 2.01, p = 0.02), but not for Caucasian children and Africans (for Caucasians, D: OR=1.35, p = 0.27, DD: OR = 0.95, p = 0.91; for Africans, D: OR = 1.70, p = 0.56, DD: OR = 1.60, p = 0.73). Furthermore, II homozygous seemed to play a positive role against INS onset for Asians (OR = 0.59, p = 0.02), but the link between II genotype and INS risk was not observed in Caucasian children and Africans (Caucasians: OR = 0.31, p = 0.06; Africans: OR = 0.50, p = 0.59). Conclusions: D allele and DD homozygous might become significant genetic molecular markers for INS susceptibility in Asian children, but the association was not observed in Caucasians or Africans. However, the conclusion from our study cannot be sustained and more investigations on larger sample in different populations are required to further clarify the role of D allele or DD homozygous in the onset of INS in difference races.

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