scholarly journals Cytotoxic effect and apoptotic activity of Parmentiera edulis DC. hexane extract on the breast cancer cell line MDA-MB-231

2016 ◽  
pp. 015-022
Author(s):  
Cynthia oacute,mez ◽  
Cynthia Pichardo ◽  
Eduardo iacute,n ◽  
Nury aacute,ndez ◽  
David Ishiwara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cytotoxic Effect ◽  
Cancer Cell Line ◽  
Hexane Extract ◽  
Apoptotic Activity

scholarly journals An Antioxidant Polysaccharide from Ganoderma lucidum Induces Apoptotic Activity in Breast Cancer Cell Line 

2022 ◽  
Author(s):  
Md. Moyen Uddin Pk ◽  
Rumana Pervin ◽  
Mohammad Shahangir Biswas ◽  
Matiar Rahman
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Ganoderma Lucidum ◽  
Cancer Cell Line ◽  
Dependent Manner ◽  
Apoptotic Activity ◽  
Mcf 7

The purpose of this study is to elucidate the apoptotic activity of Ganoderma lucidum  polysaccharide (GLP) in a human breast cancer cell line MCF-7 in vitro.  According to DPPH assay, GLP showed a good antioxidant (IC 50  value is 202.4 µg/mL). Based on MTT assay, the results showed that GLP inhibits MCF-7 cells proliferation in a dose- and time- dependent manner (p<0.001). IC 50   values of the cytotoxicity of GLP and doxorubin  were 110.907 µg/mL and 58.206 µg/mL respectively. The results from the flow cytometry indicated that GLP could induce apoptotic activity through inducing the up-regulation of the Bax and Caspase-9 and the down-regulation of the BcL-2 in MCF-7 cells. At 2×IC 50 , GLP increased the early-apoptotic and dead cells of MCF-7 from 18.23% to 34.76% and 8.45% to16.34% respectively. In conclusion, the GLP shows anticancer activity against MCF-7 through preventing the proliferation and inducing the apoptosis of MCF-7 cells. Our data provide the potential molecular targets in cancer prevention and reveal the key barriers in the current anticancer drugs development.

scholarly journals The Cytotoxic Effect of Hyssop Extract on Breast Cancer Cell Line

2019 ◽  
Vol 13 (7) ◽  
pp. 22-28
Author(s):  
Faranak Fallahian ◽  
Nafiseh Mahdavi ◽  
Mohammadreza Haeri ◽  
◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cytotoxic Effect ◽  
Cancer Cell Line

scholarly journals The tetrameric peptide LfcinB (20–25)4 derived from bovine lactoferricin induces apoptosis in the MCF-7 breast cancer cell line

RSC Advances ◽  
2019 ◽  
Vol 9 (36) ◽  
pp. 20497-20504 ◽  
Author(s):  
Jorge Rodríguez Guerra ◽  
Andrea Barragán Cárdenas ◽  
Alejandra Ochoa-Zarzosa ◽  
Joel López Meza ◽  
Adriana Umaña Pérez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cytotoxic Effect ◽  
Cancer Cell Line ◽  
Bovine Lactoferricin ◽  
Line P ◽  
Mcf 7

The cytotoxic effect of the tetrameric peptide LfcinB (20–25)4 against breast cancer cell line ATCC® HTB-22™ (MCF-7) was evaluated.

scholarly journals Selective cytotoxic effect against the MDA-MB-468 breast cancer cell line of the antibacterial palindromic peptide derived from bovine lactoferricin

RSC Advances ◽  
2020 ◽  
Vol 10 (30) ◽  
pp. 17593-17601 ◽  
Author(s):  
Andrea Barragán-Cárdenas ◽  
Maribel Urrea-Pelayo ◽  
Víctor Alfonso Niño-Ramírez ◽  
Adriana Umaña-Pérez ◽  
Jean Paul Vernot ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cytotoxic Effect ◽  
Cancer Cell Line ◽  
Alanine Scanning ◽  
Bovine Lactoferricin

The cytotoxic effect against the breast cancer cell line MDA-MB-468 of the palindromic peptide LfcinB (21–25)Pal: 1RWQWRWQWR9 and its analogous peptides, obtained via alanine scanning, was evaluated.

Characterization andin vitro cytotoxic effect of adriamycin conjugated monoclonal antibody prepared against breast cancer cell line

Breast Cancer ◽  
1997 ◽  
Vol 4 (2) ◽  
pp. 85-92
Author(s):  
Hisanori Ikegaki ◽  
Noriaki Ohuchi ◽  
Takashi Masuko ◽  
Shinya Suzuki ◽  
Yuko Harada ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Monoclonal Antibody ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cytotoxic Effect ◽  
Cancer Cell Line

scholarly journals Cytotoxic Effect of Post-Purified Herceptin Conjugated Recombinant Diphtheria Toxin on Sk-Br-3 Breast Cancer Cell Line

2017 ◽  
Vol 1 (Supplementary 1) ◽  
pp. 0-0
Author(s):  
Sahel Amoozadeh ◽  
Mohammad Morad Farajollahi ◽  
Maryam Hemmati ◽  
Parastoo Tarighi
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Diphtheria Toxin ◽  
Cytotoxic Effect ◽  
Cancer Cell Line

RGD peptide-mediated liposomal curcumin targeted delivery to breast cancer cells

2020 ◽  
pp. 088532822094936
Author(s):  
Reza Mahmoudi ◽  
Seyedeh Ashraf Mirahmadi-Babaheidri ◽  
Hamdollah Delaviz ◽  
Mohamad Hassan Fouani ◽  
Mohsen Alipour ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Targeted Delivery ◽  
Cytotoxic Effect ◽  
Cancer Cell Line ◽  
Control Group ◽  
Mcf 7

In this study, turmeric's active ingredient (Curcumin) was encapsulated into RGD modified Liposomes (RGD-Lip-Cur) its cytotoxic effect on the breast cancer cell line (MCF-7) was evaluated by MTT, flow cytometry and Caspase assay. Liposomes were characterized using transmission electron microscopy (TEM). Results demonstrated that the liposomes were spherical in shape, ranging from 70 to 100 nm. MTT assay revealed that RGD-Lip-Cur had a significant cytotoxic effect on MCF-7 cells at concentrations of 32, 16 and 4 μg/ml compared to Lip-Cur (P < 0.05) and curcumin (P < 0.01). The apoptosis assay demonstrated that RGD-Lip-Cur induces the apoptosis in MCF-7 cells (39.6% vs 40.2% for initial and secondary apoptosis) significantly more than Lip-Cur (67.7% vs 9.16% for initial and secondary apoptosis) and free curcumin (7.84% vs 38.8% for initial and secondary apoptosis). Moreover, caspase assay showed that RGD-Lip-Cur activates caspase 3/7 compared to Lip-Cur (P < 0.05) and free curcumin (P < 0.01). The RGD-Lip-Cur was similar to the control group and had no significant cytotoxicity effect. It is concluded that RGD-Lip-Cur as a novel carrier have high cytotoxicity effect on breast cancer cell line (MCF-7).

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