scholarly journals Anti-inflammatory and analgesic activities of methanol extracts of stem bark of Anthocleista djalonensis in wistar rats.

2015 ◽  
pp. 117-120 ◽  
Author(s):  
Olusayo Shorinwa ◽  
Adaora Enemuoh ◽  
Fidelia Uche
Keyword(s):  
Wistar Rats ◽  
Stem Bark ◽  
Methanol Extracts ◽  
Anti Inflammatory ◽  
Analgesic Activities

scholarly journals Investigation of the Anti-Inflammatory and Analgesic Activities of Ethanol Extract of Stem Bark of SonapathaOroxylum indicum In Vivo

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
K. Lalrinzuali ◽  
M. Vabeiryureilai ◽  
Ganesh Chandra Jagetia
Keyword(s):  
Inflammatory Diseases ◽  
Ethanol Extract ◽  
Stem Bark ◽  
The Body ◽  
Protective Measure ◽  
Analgesic Effects ◽  
Oroxylum Indicum ◽  
Anti Inflammatory ◽  
Analgesic Activities

Inflammation is all a pervasive phenomenon, which is elicited by the body in response to obnoxious stimuli as a protective measure. However, sustained inflammation leads to several diseases including cancer. Therefore it is necessary to neutralize inflammation. Sonapatha (Oroxylum indicum), a medicinal plant, is traditionally used as a medicine in Ayurveda and other folk systems of medicine. It is commonly used to treat inflammatory diseases including rheumatoid arthritis and asthma. Despite this fact its anti-inflammatory and analgesic effects are not evaluated scientifically. Therefore, the anti-inflammatory and analgesic activities of Sonapatha (Oroxylum indicum) were studied in Swiss albino mice by different methods. The hot plate, acetic acid, and tail immersion tests were used to evaluate the analgesic activity whereas xylene-induced ear edema and formalin induced paw edema tests were used to study the anti-inflammatory activity of Sonapatha. The administration of mice with 250 and 300 mg/kg b.wt. ofO. indicumreduced pain and inflammation indicating that Sonapatha possesses analgesic and anti-inflammatory activities. The maximum analgesic and anti-inflammatory activities were observed in mice receiving 300 mg/kg b.wt. ofO. indicumethanol extract.Our study indicates thatO. indicumpossesses both anti-inflammatory and analgesic activities and it may be useful as an anti-inflammatory agent in the inflammation related disorders.

scholarly journals Antinociceptive and Anti-Inflammatory Activities of Ethanolic Stem Bark Extract of Smilax zeylanica Linn. in Wistar Rats

2021 ◽  
pp. 103-113
Author(s):  
Rasheed Ahemad Shaik ◽  
Fazil Ahmad ◽  
Mohammed Abdul Aleem
Keyword(s):  
Acetic Acid ◽  
Wistar Rats ◽  
Ethanol Extract ◽  
Stem Bark ◽  
Drug Group ◽  
Bark Extract ◽  
Hot Plate ◽  
Paw Oedema ◽  
Stem Bark Extract ◽  
Anti Inflammatory

Background: Smilax zeylanica Linn (Smilaceae) is a woody climbing shrub native to Asia's tropical and subtropical highlands. Traditionally, this plant has been widely used to cure a variety of ailments. Smilax zeylanica stem bark was extracted with ethanol to test its antinociceptive and anti-inflammatory properties. Objective: To study the antinociceptive and anti-inflammatory activities of ethanolic stem bark extract of Smilax zeylanica Linn. in Wistar rats. Methods: The antinociceptive activity has been assessed in mice by formalin-induced paw licking, Eddy’s hot-plate, and acetic-acid induced abdominal stretching models. Carrageenan-induced paw oedema in rats has been conducted to explore the anti-inflammatory activity. Tween 80 (10ml/kg, p.o) was given to the control group, test drug group received ethanol extract of Smilax zeylanica (EESZ) orally at doses of 200 and 400 mg/kg, and standard drugs morphine (5 mg/kg, s.c), diclofenac sodium (10 mg/kg, i.p) were injected to the standard drug group. Results: Oral administration of ethanolic extract of Smilax zeylanica (EESZ) at test doses (200 and 400 mg/kg), produced a significant decrease of the paw licking time for 2 phases (neurogenic and inflammatory) in the formalin test, upsurge of the reaction time in Eddy’s hot plate test, and significantly decreased the abdominal stretching in the acetic acid-induced  writhes test. Ethanol extract of Smilax zeylanica significantly decreased the carrageenan-induced paw oedema. Conclusion: The ethanol extract of Smilax zeylanica possesses antinociceptive, anti-inflammatory activity, probably involving central and peripheral pathways

Anti-inflammatory and analgesic activities of the ethanolic extracts fromZanthoxylum riedelianum(Rutaceae) leaves and stem bark

2007 ◽  
Vol 59 (8) ◽  
pp. 1151-1158 ◽  
Author(s):  
Leonardo Mandalho Lima ◽  
Fábio Ferreira Perazzo ◽  
José Carlos Tavares Carvalho ◽  
Jairo Kenupp Bastos
Keyword(s):  
Stem Bark ◽  
Ethanolic Extracts ◽  
Anti Inflammatory ◽  
Analgesic Activities

scholarly journals Anti-Inflammatory Potentials of the n-Hexane Fraction of Alstonia boonei Stem Bark in Lipopolysaccharide-Induced Inflammation in Wistar Rats

2021 ◽  
Vol Volume 14 ◽  
pp. 3905-3920
Author(s):  
John Oludele Olanlokun ◽  
Adeola Oluwakemi Olowofolahan ◽  
Olusola Bodede ◽  
Adekunle Theophilus Adegbuyi ◽  
Gerhard Prinsloo ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Stem Bark ◽  
Hexane Fraction ◽  
Anti Inflammatory

scholarly journals Effects of Aqueous and Methanolic Extracts of Stem Bark of Alstonia boonei De Wild. (Apocynaceae) on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Wistar Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-15 ◽  
Author(s):  
Carine Flore Adjouzem ◽  
Ateufack Gilbert ◽  
Marius Mbiantcha ◽  
William Yousseu Nana ◽  
Vanessa Matah Marthe Mba ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Secondary Metabolites ◽  
Sodium Sulfate ◽  
Wistar Rats ◽  
Stem Bark ◽  
Dextran Sodium Sulfate ◽  
Chemical Screening ◽  
Methanol Extracts

Among the most exploited species in Cameroon, Alstonia boonei is widely used in African medicine for the relief of several pathologies including gastrointestinal disorders. This study was conducted in order to assess the effects of aqueous and methanol stem-bark extracts of Alstonia boonei on DSS- (dextran sodium sulfate-) induced intestinal colitis and to determine its antioxidant potential. The classes of secondary metabolites present in these extracts were determined by chemical screening. The production of TNF-α, IL-6, IL-1β, and PGE2 was performed by in vitro ELISA analysis. Anticolitis effects were determined using an in vivo model of ulcerative colitis induced by DSS. The colitis was induced with a double dose of DSS (3% and 1%), and the aqueous and methanol extracts were administered orally from the 6th day after commencement of induction. The phytochemical screening revealed the presence of six classes of secondary metabolites in these crude extracts: tannins, saponins, alkaloids, steroids, flavonoids, and phenols. Methanol and aqueous extracts of Alstonia boonei significantly (P<0.001) inhibited TNF-α, IL-6, IL-1β, and PGE2 production stimulated by LPS. Both extracts at all doses significantly reduced (P<0.01, P<0.001) the signs of DSS-induced colitis in the Wistar rats by decreasing inflammation and chronic colon damage. In addition, the extracts significantly (P<0.001) reduced malondialdehyde and nitric oxide levels in the colon and significantly (P<0.01) increased superoxide dismutase and catalase and reduced glutathione (P<0.05). Both extracts showed greater activity than the reference substance (prednisolone 4 mg/kg) used in this study. This study has demonstrated that aqueous and methanol extracts of Alstonia boonei stem bark have healing properties against colitis experimentally induced by DSS in rats.

scholarly journals Anti-inflammatory and Analgesic Activities of the Crude Extracts from Stem Bark of Bauhinia Guianensis

1999 ◽  
Vol 37 (4) ◽  
pp. 281-284 ◽  
Author(s):  
J.C.T. Carvalho ◽  
L.S. Santos ◽  
E.P. Viana ◽  
S.S.M.S. de Almeida ◽  
E. Marconato ◽  
...  
Keyword(s):  
Stem Bark ◽  
Crude Extracts ◽  
Anti Inflammatory ◽  
Analgesic Activities

Assessment of the antipyretic, and anti-inflammatory effects of Zanthoxylum Zanthoxyloides stem bark aqueous extract on Wistar rats

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Atèhèzi Tougoma ◽  
S. Komi Atchrimi ◽  
Adama Dénou ◽  
V. Oto-Obong Idah ◽  
U. Gideon Egesie ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Stem Bark ◽  
Zanthoxylum Zanthoxyloides ◽  
Anti Inflammatory
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