Assessment of the antipyretic, and anti-inflammatory effects of Zanthoxylum Zanthoxyloides stem bark aqueous extract on Wistar rats

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Atèhèzi Tougoma ◽  
S. Komi Atchrimi ◽  
Adama Dénou ◽  
V. Oto-Obong Idah ◽  
U. Gideon Egesie ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Stem Bark ◽  
Zanthoxylum Zanthoxyloides ◽  
Anti Inflammatory

Anti-inflammatory and anti-arthritic properties of aqueous extract of Nauclea diderrichii (Rubiaceae) stem bark in rats

2020 ◽  
Vol 20 (2) ◽  
pp. 199-212
Author(s):  
Marius Mbiantcha ◽  
Marcelle Bejoutance Djami ◽  
Gilbert Ateufack ◽  
Donatien Albert Atsamo ◽  
Gonzal Eric Tsafack ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Stem Bark ◽  
Nauclea Diderrichii ◽  
Anti Inflammatory

scholarly journals Antinociceptive and Anti-Inflammatory Activities of Ethanolic Stem Bark Extract of Smilax zeylanica Linn. in Wistar Rats

2021 ◽  
pp. 103-113
Author(s):  
Rasheed Ahemad Shaik ◽  
Fazil Ahmad ◽  
Mohammed Abdul Aleem
Keyword(s):  
Acetic Acid ◽  
Wistar Rats ◽  
Ethanol Extract ◽  
Stem Bark ◽  
Drug Group ◽  
Bark Extract ◽  
Hot Plate ◽  
Paw Oedema ◽  
Stem Bark Extract ◽  
Anti Inflammatory

Background: Smilax zeylanica Linn (Smilaceae) is a woody climbing shrub native to Asia's tropical and subtropical highlands. Traditionally, this plant has been widely used to cure a variety of ailments. Smilax zeylanica stem bark was extracted with ethanol to test its antinociceptive and anti-inflammatory properties. Objective: To study the antinociceptive and anti-inflammatory activities of ethanolic stem bark extract of Smilax zeylanica Linn. in Wistar rats. Methods: The antinociceptive activity has been assessed in mice by formalin-induced paw licking, Eddy’s hot-plate, and acetic-acid induced abdominal stretching models. Carrageenan-induced paw oedema in rats has been conducted to explore the anti-inflammatory activity. Tween 80 (10ml/kg, p.o) was given to the control group, test drug group received ethanol extract of Smilax zeylanica (EESZ) orally at doses of 200 and 400 mg/kg, and standard drugs morphine (5 mg/kg, s.c), diclofenac sodium (10 mg/kg, i.p) were injected to the standard drug group. Results: Oral administration of ethanolic extract of Smilax zeylanica (EESZ) at test doses (200 and 400 mg/kg), produced a significant decrease of the paw licking time for 2 phases (neurogenic and inflammatory) in the formalin test, upsurge of the reaction time in Eddy’s hot plate test, and significantly decreased the abdominal stretching in the acetic acid-induced  writhes test. Ethanol extract of Smilax zeylanica significantly decreased the carrageenan-induced paw oedema. Conclusion: The ethanol extract of Smilax zeylanica possesses antinociceptive, anti-inflammatory activity, probably involving central and peripheral pathways

scholarly journals Possible Antioxidant and Haematinic Properties of the Stem Bark of Theobroma cacao L. in Wistar Rats

2021 ◽  
pp. 18-26
Author(s):  
B. O. Oluwatayo ◽  
T. A. Kolawole ◽  
C. C. Wali ◽  
O. A. Olayanju ◽  
A. E. J. Okwori
Keyword(s):  
Aqueous Extract ◽  
Theobroma Cacao ◽  
Wistar Rats ◽  
Antioxidant Activities ◽  
Research Work ◽  
Stem Bark ◽  
Dependent Manner ◽  
Group 2 ◽  
Dose Dependent ◽  
Theobroma Cacao L

Background: This study investigated the potential antioxidant effects of aqueous extract of the stem bark of Theobroma cacao L. in Wistar rats. Methods: Twenty Wistar rats weighing between 126 g – 224 g were grouped randomly into 4groups of 5 rats each. Group 1 served as control and received water while groups 2, 3 and 4 rats were given 1000mg/kg, 3000mg/kg and 5000mg/kg b.wt of the extract respectively for 28days. On the 29th day, the rats were anaesthetized and blood samples were collected for analysis of some haematological parameters, enzymatic and non- enzymatic antioxidant activities. Results: The results obtained showed that there was significant increase (p<0.001) in SOD, Catalase activities and MDA levels in a dose dependent manner. The results also showed significant increase (p<0.001) in RBC Group 2, 3 and 4 rats when compared to the Group1. Significant increase was also observed in Hemoglobin (Hb) and Hematocrit (Hct) level in group 2 and 3 rats (p<0.001). Mean corpuscular volume was significantly increased in group 2 rats (p<0.001). Conclusion: The findings from this study showed the antioxidant and hematinic potentials of the stem bark of Theobroma cacao L.The aqueous extract of the stem bark of Theobroma cacao L. has a potential antioxidative and hematinic effects in Wistar rats. This is largely due to its rich phytochemical and nutritive contents. Further research work will be needed to see the possible application of these properties in humans.

Analgesic and Anti-Inflammatory Effects of Aqueous Extract of Zea mays Husk in Male Wistar Rats

2010 ◽  
Vol 13 (2) ◽  
pp. 343-347 ◽  
Author(s):  
Bamidele V. Owoyele ◽  
Muhammed N. Negedu ◽  
Samuel O. Olaniran ◽  
Samuel A. Onasanwo ◽  
Stephen O. Oguntoye ◽  
...  
Keyword(s):  
Zea Mays ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Male Wistar Rats ◽  
Anti Inflammatory

scholarly journals Anti-Inflammatory Potentials of the n-Hexane Fraction of Alstonia boonei Stem Bark in Lipopolysaccharide-Induced Inflammation in Wistar Rats

2021 ◽  
Vol Volume 14 ◽  
pp. 3905-3920
Author(s):  
John Oludele Olanlokun ◽  
Adeola Oluwakemi Olowofolahan ◽  
Olusola Bodede ◽  
Adekunle Theophilus Adegbuyi ◽  
Gerhard Prinsloo ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Stem Bark ◽  
Hexane Fraction ◽  
Anti Inflammatory

scholarly journals Effect of Allanblackia floribunda stem bark aqueous extract in male albino wistar rats: androgenic activities and penile nitric oxide (NO) production

2021 ◽  
Vol 7 (2) ◽  
pp. 63-73
Author(s):  
Antoine Kada Sanda ◽  
David Fotsing ◽  
Oumar Mahamat ◽  
Vijayakumar Natesan ◽  
Jayaprakash Rajendran ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Stem Bark ◽  
No Production

scholarly journals Evaluation of the curative role, Anti-inflammatory and anti-oxidative activity of some dietary spices on carrageenan induced paw edema in albino Wistar rats

2020 ◽  
Vol 10 (5-s) ◽  
pp. 90-96
Author(s):  
Khaoula Bouaoud ◽  
Noreddine Menadi ◽  
Mohammed Zairi ◽  
Sofiane Bouazza ◽  
Hadjer Bekhadda ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Red Pepper ◽  
Total Phenolic ◽  
Control Group ◽  
Paw Edema ◽  
Standard Drug ◽  
Reference Drug ◽  
Anti Inflammatory ◽  
Dietary Spices

Background: Inflammation is a major burning problem worldwide and billions of individuals are affected. Some of the spices used daily in Algerian cuisine have been known to possess major anti-inflammatory effects. Turmeric, red pepper, ginger, cinnamon and cumin  etc. are a few of the wide spectrum of spices used in Algeria. The aim of the study was to investigate the antiinflammatory effect  and anti actvity of some dietary spices in carrageenan induced models of inflammation on Wistar  rats. Methods: Albino wistar rats were divided into four groups. Inflammation was induced on the animal by injecting the right hand paw with carrageenan (0.1 ml of 1%). Group 1  was fed with food and water and  treated with carrageenan (control) whereas group 2 and  3 treated with different doses (100 and 200 mg/kg/bw) of aqueous extract of some dietary spices with carrageenan, respectively. Group 4  treated with standard drug diclofenac sodium (10 mg/kg b.w., reference drug for inflammation), once for 24 hrs. Results: The content of total phenolic was 137.2±21.6 mg/g and flavonoids 122.3±5.8 mg/g. After 60, 120, 180, 240 and 300 min, the data indicate that  some dietary spices 100 and 200 mg/kg was significantly effective reducing paw edema volumes induced by carrageenan compared to control (p <0.01). The levels of serum pro-inflammatory white blood cells, neutrophile, lymphocyte, monocyte,  eosinophile, total protein and protein c reactive and total cephalin KADIN  and platelts in the control group were significantly increased by carrageenan injection compared with the normal group. The rats pretreated with some spices 100 and 200 mg/kg had significantly lower levels of pro-inflammatory to compare control group. The paw edema in carrageenan-induced rats was considerably reduced by treating with 100 and 200  mg/kg aqueous extract of some dietary spices when compared to the untreated  rats (p<0.001). Conclusion : The present results clearly demonstarted that carrageenan significantly increased paw edema whereas some dietary treated rats significantly decreased the paw edema. The study underlines the importance of some of the frequently used spices (Turmeric, red pepper, ginger, cinnamon and cumin)  in the treatment of inflammation.

Sign in / Sign up

Export Citation Format

Share Document