scholarly journals Where do we go from here: Challenges and the future of endocrine disrupting compound screening and testing

2016 ◽  
Author(s):  
Vickie S Wilson ◽  
Gerald A LeBlanc ◽  
Seth Kullman ◽  
Kevin Crofton ◽  
Patricia Schmieder ◽  
...  
Keyword(s):  
Endocrine Disruption ◽  
Endocrine Disrupting Compounds ◽  
Environmental Toxicology ◽  
Current Status ◽  
Endocrine Regulation ◽  
Endocrine Activity ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting ◽  
Compound Screening

Worldwide concern about the impacts of endocrine disrupting compounds on both human and environmental health has led to implementation of multiple screening and testing programs. In most cases these programs have focused on impacts to the estrogen, androgen and thyroid hormone (EAT) signaling pathways. The goal of the presentations in session five of the Society of Environmental Toxicology and Chemistry (SETAC) North America Focused Topic Meeting: Endocrine Disruption (February 4 – 6, 2014) was to discuss moving beyond EAT pathways to address current challenges and identify future approaches for the expansion of screening and testing programs. The session was chaired by Drs. Gerald A. LeBlanc and Vickie S. Wilson and included five presentations. Dr. Gerald A. LeBlanc provided insight on non-EAT endocrine targets that are known to be susceptible to endocrine disrupting compounds. Dr. Seth Kullman gave an overview of emerging technologies that hold promise for the screening of chemicals for interaction with EAT and other endocrine pathways. These were followed by two presentations on the current status and future promise of computational (Dr. Kevin Crofton) and in silico (Dr. Patricia Schmieder) approaches for screening and ranking chemicals for endocrine activity. Dr. Miriam Jacobs culminated the session with an overview of the current understanding of the role of epigenetics in endocrine regulation and approaches for evaluating chemicals for their ability to disrupt the epigenetic regulation of endocrine processes.

scholarly journals Where do we go from here: Challenges and the future of endocrine disrupting compound screening and testing

2016 ◽  
Author(s):  
Vickie S Wilson ◽  
Gerald A LeBlanc ◽  
Seth Kullman ◽  
Kevin Crofton ◽  
Patricia Schmieder ◽  
...  
Keyword(s):  
Endocrine Disruption ◽  
Endocrine Disrupting Compounds ◽  
Environmental Toxicology ◽  
Current Status ◽  
Endocrine Regulation ◽  
Endocrine Activity ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting ◽  
Compound Screening

Worldwide concern about the impacts of endocrine disrupting compounds on both human and environmental health has led to implementation of multiple screening and testing programs. In most cases these programs have focused on impacts to the estrogen, androgen and thyroid hormone (EAT) signaling pathways. The goal of the presentations in session five of the Society of Environmental Toxicology and Chemistry (SETAC) North America Focused Topic Meeting: Endocrine Disruption (February 4 – 6, 2014) was to discuss moving beyond EAT pathways to address current challenges and identify future approaches for the expansion of screening and testing programs. The session was chaired by Drs. Gerald A. LeBlanc and Vickie S. Wilson and included five presentations. Dr. Gerald A. LeBlanc provided insight on non-EAT endocrine targets that are known to be susceptible to endocrine disrupting compounds. Dr. Seth Kullman gave an overview of emerging technologies that hold promise for the screening of chemicals for interaction with EAT and other endocrine pathways. These were followed by two presentations on the current status and future promise of computational (Dr. Kevin Crofton) and in silico (Dr. Patricia Schmieder) approaches for screening and ranking chemicals for endocrine activity. Dr. Miriam Jacobs culminated the session with an overview of the current understanding of the role of epigenetics in endocrine regulation and approaches for evaluating chemicals for their ability to disrupt the epigenetic regulation of endocrine processes.

scholarly journals Facile Synthesis of Porous ZnO Nanoparticles Efficient for Photocatalytic Degradation of Biomass-Derived Bisphenol A Under Simulated Sunlight Irradiation

2021 ◽  
Vol 8 ◽  
Author(s):  
Yujie Wang ◽  
Kang Hu ◽  
Zhiyu Yang ◽  
Chenlu Ye ◽  
Xin Li ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Photocatalytic Degradation ◽  
Inorganic Ions ◽  
Endocrine Disrupting Compounds ◽  
Degradation Process ◽  
Sunlight Irradiation ◽  
Calcination Temperatures ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting ◽  
Photocatalytic Removal

Bisphenol A (BPA) produced from biomass is a typical endocrine disrupting compound that is carcinogenic and genotoxic and can be accumulated in water due to its extensive use and difficult degradation. In this study, the porous ZnO photocatalyst with core-shell structure and large surface area was successfully developed for the efficient photocatalytic degradation of BPA. The various effects of calcination temperatures, BPA concentrations, ZnO dosages, pH and inorganic ions on the degradation performance were systemically studied. The results showed that 99% degradation of BPA was achieved in 1 h using the porous ZnO calcined at 550°C under the conditions of 30 mg/L BPA, 1 g/L ZnO, and pH of 6.5. Besides, the inhibition effects of anions for the photocatalytic removal of BPA decreased in the order of H2PO4- > HCO3- > SO42- > Cl−, while the cations K+, Ca2+, and Na+ had little effect on the photocatalytic degradation of BPA. The results of scavenging experiments showed that h+, ·O2-, and e− played the key role in the photocatalytic degradation process. Finally, the main pathways of BPA degradation were proposed based on ten intermediates found in the degradation process. This work may provide a good guideline to degrade various endocrine disrupting compounds in wastewater treatment.

scholarly journals Endocrine Disruptors and Leydig Cell Function

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
K. Svechnikov ◽  
G. Izzo ◽  
L. Landreh ◽  
J. Weisser ◽  
O. Söder
Keyword(s):  
Leydig Cells ◽  
Reproductive Tract ◽  
Cell Function ◽  
Large Body ◽  
External Genitalia ◽  
Endocrine Disrupting Compounds ◽  
Male Reproductive Tract ◽  
Adult Age ◽  
Endocrine Disrupting

During the past decades, a large body of information concerning the effects of endocrine disrupting compounds (EDCs) on animals and humans has been accumulated. EDCs are of synthetic or natural origin and certain groups are known to disrupt the action of androgens and to impair the development of the male reproductive tract and external genitalia. The present overview describes the effects of the different classes of EDCs, such as pesticides, phthalates, dioxins, and phytoestrogens, including newly synthesized resveratrol analogs on steroidogenesis in Leydig cells. The potential impact of these compounds on androgen production by Leydig cells during fetal development and in the adult age is discussed. In addition, the possible role of EDCs in connection with the increasing frequency of abnormalities in reproductive development in animals and humans is discussed.

Defining Endocrine Disruption

2017 ◽  
Author(s):  
Heather B. Patisaul ◽  
Scott M. Belcher
Keyword(s):  
Endocrine Disruption ◽  
Chemical Substance ◽  
Comprehensive Treatment ◽  
Endocrine Disrupting Compound ◽  
Specific Effects ◽  
Early Life Exposure ◽  
Endocrine Disrupting ◽  
Definition Of ◽  
Multigenerational Effects ◽  
Dose Responses

Chapter 2 reviews the origin of the concept of endocrine disruption and presents a comprehensive treatment of the changing and often competing definitions of endocrine disruptors. The factors influencing the different definitions, impacts of including specific terms, such as “adverse” or “harm,” in this definition, and the important influences surrounding a specific definition are examined. Building on this background, the concept and definition of “neuroendocrine disruption” as “an exogenous chemical substance or mixture that alters the structure or function(s) of the neuroendocrine system” are presented. The distinctions between neurotoxicity and neuroendocrine disruption are delineated, and sources of endocrine-disrupting compound (EDC) exposures from man-made chemicals and “natural” compounds are discussed. Key concepts related to EDC action, including critical windows of sensitivity, early life exposure and later in life disease, multigenerational effects, non-linear and non-monotonic dose responses, low-dose and sex-specific effects, along with key toxicological definitions, are presented.

Sign in / Sign up

Export Citation Format

Share Document