Tributyltin: Advancing the Science on Assessing Endocrine Disruption with an Unconventional Endocrine-Disrupting Compound

2017 ◽  
pp. 65-127 ◽  
Author(s):  
Laurent Lagadic ◽  
Ioanna Katsiadaki ◽  
Ron Biever ◽  
Patrick D. Guiney ◽  
Natalie Karouna-Renier ◽  
...  
Keyword(s):  
Endocrine Disruption ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting

Defining Endocrine Disruption

2017 ◽  
Author(s):  
Heather B. Patisaul ◽  
Scott M. Belcher
Keyword(s):  
Endocrine Disruption ◽  
Chemical Substance ◽  
Comprehensive Treatment ◽  
Endocrine Disrupting Compound ◽  
Specific Effects ◽  
Early Life Exposure ◽  
Endocrine Disrupting ◽  
Definition Of ◽  
Multigenerational Effects ◽  
Dose Responses

Chapter 2 reviews the origin of the concept of endocrine disruption and presents a comprehensive treatment of the changing and often competing definitions of endocrine disruptors. The factors influencing the different definitions, impacts of including specific terms, such as “adverse” or “harm,” in this definition, and the important influences surrounding a specific definition are examined. Building on this background, the concept and definition of “neuroendocrine disruption” as “an exogenous chemical substance or mixture that alters the structure or function(s) of the neuroendocrine system” are presented. The distinctions between neurotoxicity and neuroendocrine disruption are delineated, and sources of endocrine-disrupting compound (EDC) exposures from man-made chemicals and “natural” compounds are discussed. Key concepts related to EDC action, including critical windows of sensitivity, early life exposure and later in life disease, multigenerational effects, non-linear and non-monotonic dose responses, low-dose and sex-specific effects, along with key toxicological definitions, are presented.

scholarly journals Where do we go from here: Challenges and the future of endocrine disrupting compound screening and testing

2016 ◽  
Author(s):  
Vickie S Wilson ◽  
Gerald A LeBlanc ◽  
Seth Kullman ◽  
Kevin Crofton ◽  
Patricia Schmieder ◽  
...  
Keyword(s):  
Endocrine Disruption ◽  
Endocrine Disrupting Compounds ◽  
Environmental Toxicology ◽  
Current Status ◽  
Endocrine Regulation ◽  
Endocrine Activity ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting ◽  
Compound Screening

Worldwide concern about the impacts of endocrine disrupting compounds on both human and environmental health has led to implementation of multiple screening and testing programs. In most cases these programs have focused on impacts to the estrogen, androgen and thyroid hormone (EAT) signaling pathways. The goal of the presentations in session five of the Society of Environmental Toxicology and Chemistry (SETAC) North America Focused Topic Meeting: Endocrine Disruption (February 4 – 6, 2014) was to discuss moving beyond EAT pathways to address current challenges and identify future approaches for the expansion of screening and testing programs. The session was chaired by Drs. Gerald A. LeBlanc and Vickie S. Wilson and included five presentations. Dr. Gerald A. LeBlanc provided insight on non-EAT endocrine targets that are known to be susceptible to endocrine disrupting compounds. Dr. Seth Kullman gave an overview of emerging technologies that hold promise for the screening of chemicals for interaction with EAT and other endocrine pathways. These were followed by two presentations on the current status and future promise of computational (Dr. Kevin Crofton) and in silico (Dr. Patricia Schmieder) approaches for screening and ranking chemicals for endocrine activity. Dr. Miriam Jacobs culminated the session with an overview of the current understanding of the role of epigenetics in endocrine regulation and approaches for evaluating chemicals for their ability to disrupt the epigenetic regulation of endocrine processes.

scholarly journals Where do we go from here: Challenges and the future of endocrine disrupting compound screening and testing

2016 ◽  
Author(s):  
Vickie S Wilson ◽  
Gerald A LeBlanc ◽  
Seth Kullman ◽  
Kevin Crofton ◽  
Patricia Schmieder ◽  
...  
Keyword(s):  
Endocrine Disruption ◽  
Endocrine Disrupting Compounds ◽  
Environmental Toxicology ◽  
Current Status ◽  
Endocrine Regulation ◽  
Endocrine Activity ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting ◽  
Compound Screening

Worldwide concern about the impacts of endocrine disrupting compounds on both human and environmental health has led to implementation of multiple screening and testing programs. In most cases these programs have focused on impacts to the estrogen, androgen and thyroid hormone (EAT) signaling pathways. The goal of the presentations in session five of the Society of Environmental Toxicology and Chemistry (SETAC) North America Focused Topic Meeting: Endocrine Disruption (February 4 – 6, 2014) was to discuss moving beyond EAT pathways to address current challenges and identify future approaches for the expansion of screening and testing programs. The session was chaired by Drs. Gerald A. LeBlanc and Vickie S. Wilson and included five presentations. Dr. Gerald A. LeBlanc provided insight on non-EAT endocrine targets that are known to be susceptible to endocrine disrupting compounds. Dr. Seth Kullman gave an overview of emerging technologies that hold promise for the screening of chemicals for interaction with EAT and other endocrine pathways. These were followed by two presentations on the current status and future promise of computational (Dr. Kevin Crofton) and in silico (Dr. Patricia Schmieder) approaches for screening and ranking chemicals for endocrine activity. Dr. Miriam Jacobs culminated the session with an overview of the current understanding of the role of epigenetics in endocrine regulation and approaches for evaluating chemicals for their ability to disrupt the epigenetic regulation of endocrine processes.

High efficiency removal and recovery of an endocrine disrupting compound–bisphenol AF from wastewaters

2013 ◽  
Vol 116 ◽  
pp. 145-153 ◽  
Author(s):  
Lei Zhang ◽  
Junna Lv ◽  
Tianci Xu ◽  
Lijun Yang ◽  
Xiaoqing Jiang ◽  
...  
Keyword(s):  
High Efficiency ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting ◽  
Bisphenol Af ◽  
Removal And Recovery

scholarly journals Epigenetics, Evolution, Endocrine Disruption, Health, and Disease

Endocrinology ◽  
2006 ◽  
Vol 147 (6) ◽  
pp. s4-s10 ◽  
Author(s):  
David Crews ◽  
John A. McLachlan
Keyword(s):  
Mental Health ◽  
Recent Work ◽  
Endocrine Disruption ◽  
Endocrine Disrupting Chemicals ◽  
Epigenetic Mechanisms ◽  
Physical And Mental Health ◽  
Risk Levels ◽  
Endocrine Disrupting ◽  
Increase Risk ◽  
Health And Disease

Abstract Endocrine-disrupting chemicals (EDCs) in the environment have been linked to human health and disease. This is particularly evident in compounds that mimic the effects of estrogens. Exposure to EDCs early in life can increase risk levels of compromised physical and mental health. Epigenetic mechanisms have been implicated in this process. Transgenerational consequences of EDC exposure is also discussed in both a proximate (mechanism) and ultimate (evolution) context as well as recent work suggesting how such transmission might become incorporated into the genome and subject to selection. We suggest a perspective for exploring and ultimately coming to understand diseases that may have environmental or endocrine origins.

Nanocomposite Membrane-Based Photocatalytic Reactor for Degradation of Endocrine-Disrupting Compound in Water

2018 ◽  
pp. 403-439
Author(s):  
Hazlini Dzinun ◽  
Mohd Hafiz Dzarfan Othman ◽  
A. F. Ismail ◽  
Mohd Hafiz Puteh ◽  
Mukhlis A. Rahman ◽  
...  
Keyword(s):  
Nanocomposite Membrane ◽  
Photocatalytic Reactor ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting

scholarly journals Facile Synthesis of Porous ZnO Nanoparticles Efficient for Photocatalytic Degradation of Biomass-Derived Bisphenol A Under Simulated Sunlight Irradiation

2021 ◽  
Vol 8 ◽  
Author(s):  
Yujie Wang ◽  
Kang Hu ◽  
Zhiyu Yang ◽  
Chenlu Ye ◽  
Xin Li ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Photocatalytic Degradation ◽  
Inorganic Ions ◽  
Endocrine Disrupting Compounds ◽  
Degradation Process ◽  
Sunlight Irradiation ◽  
Calcination Temperatures ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting ◽  
Photocatalytic Removal

Bisphenol A (BPA) produced from biomass is a typical endocrine disrupting compound that is carcinogenic and genotoxic and can be accumulated in water due to its extensive use and difficult degradation. In this study, the porous ZnO photocatalyst with core-shell structure and large surface area was successfully developed for the efficient photocatalytic degradation of BPA. The various effects of calcination temperatures, BPA concentrations, ZnO dosages, pH and inorganic ions on the degradation performance were systemically studied. The results showed that 99% degradation of BPA was achieved in 1 h using the porous ZnO calcined at 550°C under the conditions of 30 mg/L BPA, 1 g/L ZnO, and pH of 6.5. Besides, the inhibition effects of anions for the photocatalytic removal of BPA decreased in the order of H2PO4- > HCO3- > SO42- > Cl−, while the cations K+, Ca2+, and Na+ had little effect on the photocatalytic degradation of BPA. The results of scavenging experiments showed that h+, ·O2-, and e− played the key role in the photocatalytic degradation process. Finally, the main pathways of BPA degradation were proposed based on ten intermediates found in the degradation process. This work may provide a good guideline to degrade various endocrine disrupting compounds in wastewater treatment.

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