scholarly journals Ganglionic melanoma without cutaneous localization: primitive, or metastasis?

2020 ◽  
Vol 11 (e) ◽  
pp. e175.1-e175.3
Author(s):  
Asmae Rasso ◽  
Zakia Douhi ◽  
Sara Elloudi
1988 ◽  
Vol 74 (5) ◽  
pp. 609-615 ◽  
Author(s):  
Silvia Moretti ◽  
Marco Santucci ◽  
Laura Brogelli ◽  
Alessandro Palermo ◽  
Umberto Maria Reali ◽  
...  

Continuing controversy exists concerning a possible relation between neoplastic cells of malignant fibrous histiocytoma (MFH) and the mononuclear phagocyte system. The aim of this study was to investigate the membrane and cytoenzymatic phenotype of a primary cutaneous MFH, storiform pleomorphic type, and to compare these data with ultrastructural observations. Cytoplasmic proteins (acid phosphatase, non specific esterase, alpha-1 antitrypsin, and lysozyme) suggestive of a mononuclear phagocyte origin were demonstrated in varying amounts in neoplastic cells infiltrating the dermis. Consistent with these data, two (LeuM3 and OKM5) out of four (OKM1 and LeuM1) monoclonal antibodies directed against mononuclear phagocyte antigens stained most of the neoplastic cells. Class II MCH antigens (DR and DQ) were variably expressed on distinct groups of neoplastic cells, suggesting different activation/differentiation states. The results favor the view that the present case of primary cutaneous MFH was of mononuclear phagocyte origin. However, the observed phenotypic profile was expressed on neoplastic cells irrespective of their ultrastructural morphology (histiocytic or fibroblastic). Together with previous data in the literature, the latter finding corroborates the view that distinction between these two cell types in MFH is likely to reflect divergent growth and differentiation patterns rather than histogenesis.


2018 ◽  
Vol 24 (4) ◽  
pp. 701-703 ◽  
Author(s):  
G. Genovese ◽  
G. Nazzaro ◽  
S. Alberti Violetti ◽  
E. Passoni ◽  
E. Berti

2021 ◽  
pp. 35-36
Author(s):  
Tannistha Chakraborty ◽  
Vamsi Krishna ◽  
T. Raghupathy

Lipoma, a benign neoplasm of adipocytes, is the most common mesenchymal soft tissue tumor of adulthood, but rarely present with huge sizes in their cutaneous localization. Liposarcomas are the second most common soft tissue sarcoma following malignant brous histiocytoma. They comprise approximately 16-18% of all malignant soft tissue tumours. It is most common in the trunk followed by lower extremity, upper extremity and head and neck.. While lipomas can be clinically diagnosed , transformation of lipomas into liposarcoma is rare. Here we report the case of a 55 gentleman, who came with a history of swelling over the right shoulder with a probable malignant transformation due to history of long duration of presence of swelling. Management is usually by wide excision. Local radiation and chemotherapy may be necessary for high grade lesions.


2002 ◽  
Vol 147 (4) ◽  
pp. 807-807 ◽  
Author(s):  
A. Baldi ◽  
L. Rossiello ◽  
R. Rossiello ◽  
F. Baldi

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