scholarly journals Single Oral Dose Toxicity Test of ACM(Added Chongmyung-tang) in Sprague-Dawley Rat

2012 ◽  
Vol 23 (2) ◽  
pp. 121-128 ◽  
Author(s):  
Woo-Chang Choi ◽  
In-Chul Jung ◽  
Jong-Soon Lim ◽  
Seung-Hyung Kim ◽  
Sang-Ryong Lee
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Toxicity Test ◽  
Sprague Dawley ◽  
Sprague Dawley Rat

A 26-Week Repeated Oral Dose Toxicity Test and a 4-Week Recovery Test of Cassia tora L. Water Extract in Sprague-Dawley Rats

2018 ◽  
Vol 26 (2) ◽  
pp. 157-169
Author(s):  
Jong Hyun Nho ◽  
Jong Choon Kim ◽  
Hyun Woo Cho ◽  
Mu Jin Lee ◽  
Ho Kyung Jung ◽  
...  
Keyword(s):  
Oral Dose ◽  
Toxicity Test ◽  
Water Extract ◽  
Sprague Dawley ◽  
Cassia Tora ◽  
Recovery Test ◽  
Sprague Dawley Rats

scholarly journals Interspecies Comparison of Pharmacokinetics of the Novel Triazole Antifungal Agent SYN-2869 and Its Derivatives

2000 ◽  
Vol 44 (4) ◽  
pp. 910-915 ◽  
Author(s):  
Jehangir K. Khan ◽  
Hashem Montaseri ◽  
Marzena Poglod ◽  
Hai-Zhi Bu ◽  
Zhong Zuo ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Half Life ◽  
Animal Species ◽  
Intravenous Dose ◽  
Single Intravenous Dose ◽  
Sprague Dawley ◽  
Time Curve ◽  
Toxicological Evaluation ◽  
Significant Difference

ABSTRACT The pharmacokinetics and distribution in tissue of several novel triazole antifungal agents were studied in different animal species in order to select an appropriate lead compound. The purpose of the study was also to determine species differences in pharmacokinetics for SYN azoles to select the most appropriate species for secondary efficacy and toxicological evaluation of the selected compound. SYN-2836, SYN-2869, SYN-2903, and SYN-2921 were rapidly absorbed into the systemic circulation and reached maximum concentrations (C maxs) of 7.31 ± 2.53, 6.29 ± 0.85, 6.16 ± 0.39, and 3.41 ± 0.34 μg/ml, respectively, in BALB/c mice after administration of an oral dose of 50 mg/kg of body weight, with bioavailability being greater than 45% in all mice. The areas under the concentration-time curve from time zero to infinity (AUC0–∞s) after administration of a single intravenous dose of 20 mg/kg to mice varied between 25.0 and 63.6 μg · h/ml. The half-life was in the range of 4.5 to 6 h. In Sprague-Dawley rats there was no significant difference in AUC0–∞ after administration of a single intravenous dose of 20 mg/kg, but on oral administration, the bioavailability of SYN-2836 was extremely low, while that of SYN-2869 was only 14.7%. In New Zealand White rabbits the C max and the time to reach C max for SYN-2836 and SYN-2869 after administration of a single oral dose of 50 mg/kg were similar. There were significant differences in AUC0–∞ and half-life between SYN-2836 and SYN-2869. On the other hand, in beagle dogs theC max and AUC0–∞ of SYN-2836 after administration of a single oral dose of 30 mg/kg were 4.82 ± 1.54 μg/ml and 41.8 ± 15.7 μg · h/ml, respectively, which were threefold higher than those of SYN-2869. The concentrations of the SYN compounds in tissue indicated that the AUC0–∞s of SYN-2836, SYN-2869, SYN-2903, and SYN-2921 in mouse lungs were significantly different from each other. The ratios of the concentrations of the SYN azoles in lungs to those in plasma were also significantly different from those for itraconazole. Among the SYN azoles the highest concentration in the lungs was found for SYN-2869. The higher level of distribution of SYN-2869 into lung tissue was considered to contribute to the potent efficacy in respiratory tract infection models compared with the potency of itraconazole. Significant differences in the pharmacokinetics of these compounds were observed in different animal species, and selection of an animal model for further evaluation was based on results obtained from these studies.

scholarly journals Mouse Single Oral Dose Toxicity Test of Lactobacillus-fermented Araliae Continentalis Radix Aqueous Extracts (fACR)

2016 ◽  
Vol 26 (2) ◽  
pp. 204-211
Author(s):  
Young-Mi Jung ◽  
Sae-Kwang Ku ◽  
Dong Sub Lee ◽  
Kisang Kwon
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Toxicity Test ◽  
Aqueous Extracts
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