Study on a Single Oral Dose Toxicity Test of Horse Placenta Hydrolysate Extract in Sprague-Dawley Rats

2014 ◽  
Vol 31 (1) ◽  
pp. 105-110
Author(s):  
In Ho Yeo ◽  
Ee Hwa Kim ◽  
Eun Yong Lee
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Toxicity Test ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

A 26-Week Repeated Oral Dose Toxicity Test and a 4-Week Recovery Test of Cassia tora L. Water Extract in Sprague-Dawley Rats

2018 ◽  
Vol 26 (2) ◽  
pp. 157-169
Author(s):  
Jong Hyun Nho ◽  
Jong Choon Kim ◽  
Hyun Woo Cho ◽  
Mu Jin Lee ◽  
Ho Kyung Jung ◽  
...  
Keyword(s):  
Oral Dose ◽  
Toxicity Test ◽  
Water Extract ◽  
Sprague Dawley ◽  
Cassia Tora ◽  
Recovery Test ◽  
Sprague Dawley Rats

scholarly journals A Thirteen Week Repeated Oral Dose Toxicity Test and A Four Week Recovery Test of ACM(Added Chongmyung-tang) in Sprague-Dawley Rats

2012 ◽  
Vol 23 (3) ◽  
pp. 143-160 ◽  
Author(s):  
Dae-Myung Park ◽  
Sang-Ryong Lee ◽  
Jong-Soon Lim ◽  
Seung-Hyung Kim ◽  
In-Chul Jung
Keyword(s):  
Oral Dose ◽  
Toxicity Test ◽  
Sprague Dawley ◽  
Recovery Test ◽  
Sprague Dawley Rats

scholarly journals Single Oral Dose Toxicity Test of ACM(Added Chongmyung-tang) in Sprague-Dawley Rat

2012 ◽  
Vol 23 (2) ◽  
pp. 121-128 ◽  
Author(s):  
Woo-Chang Choi ◽  
In-Chul Jung ◽  
Jong-Soon Lim ◽  
Seung-Hyung Kim ◽  
Sang-Ryong Lee
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Toxicity Test ◽  
Sprague Dawley ◽  
Sprague Dawley Rat

scholarly journals Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dong Liang ◽  
Jing Ma ◽  
Bo Wei
Keyword(s):  
Oral Dose ◽  
Oral Absorption ◽  
Jugular Vein ◽  
Plasma Concentrations ◽  
Pharmacokinetic Data ◽  
Simulated Weightlessness ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Interaction Kinetics ◽  
Kinetics Of

AbstractTo investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat model of microgravity. Fasted control and TS, jugular-vein-cannulated, male Sprague-Dawley rats received either a single 5 mg/kg intravenous dose or a single 10 mg/kg oral dose of moxifloxacin alone or with a 0.625 mL/kg oral dose of Maalox or a 1.43 mL/kg oral dose of Pepto-Bismol. Plasma concentrations of moxifloxacin were measured by HPLC. Pharmacokinetic data were analyzed using WinNonlin. Simulated weightlessness had no effect on moxifloxacin disposition after intravenous administration but significantly decreased the extent of moxifloxacin oral absorption. The coadministration of moxifloxacin with Maalox to either control or TS rats caused significant reductions in the rate and extent of moxifloxacin absorption. In contrast, the coadministration of moxifloxacin with Pepto-Bismol to TS rats had no significant effect on either the rate or the extent of moxifloxacin absorption. These interactions showed dose staggering when oral administrations of Pepto-Bismol and moxifloxacin were separated by 60 min in control rats but not in TS rats. Dose staggering was more apparent after the coadministration of Maalox and moxifloxacin in TS rats.

scholarly journals Effects of Xiang Sha Yang Wei Wan on Ethanol-Induced Gastric Ulcer in Sprague Dawley Rats: a Histological Study

2020 ◽  
Vol 12 (2) ◽  
Author(s):  
Al-Qaraghuli AMS ◽  
Abdel Wahab EMN ◽  
Al-Ani IM ◽  
Faisal GG
Keyword(s):  
Gastric Ulcer ◽  
Oral Dose ◽  
Histological Study ◽  
Treated Group ◽  
Ethanol Administration ◽  
Gastric Mucosal Lesion ◽  
Sprague Dawley ◽  
Group I ◽  
Sprague Dawley Rats ◽  
Group Ii

Introduction: Xiang Sha Yang Wei Wan (XSYWW) is a Chinese traditional medicine that is used for gastrointestinal disorders, specifically gastric ulcer in many countries of South-East Asia. The aim of the study was to evaluate the potential effects of XSYWW on ethanol-induced gastric ulcer in rats by means of histological Study. On a similar basis of treatment, ranitidine, a conventional medication was used as gold standard. Methods: Fifty five male Sprague-Dawley rats (250-300 gm) were divided into four groups. Group I (ethanol treated group) was the control group and gastric ulcers were induced by administering 100% ethanol (1 ml/200 g). Group II (Pre-treatment group) was divided into two subgroups; they were orally fed with 1.0 gm/kg and 2.0 gm/kg respectively of XSYWW solution. Thirty minutes later they were administered with absolute ethanol as in group I. Group III, was given an oral dose of 2gm/kg of XSYWW solution after one hour of ethanol administration. Group IV was given an oral dose of 200mg/kg ranitidine solution after one hour of ethanol administration. Five rats from groups I, III and IV were sacrificed on day 1, 2 and 3 while the animals of group II were sacrificed one hour after ethanol administration. Results: Histological study of the stomachs from ethanol treated rats showed multiple ulcers of various depths that reached the muscularis and the serosa. Conclusion: Pre or post-treated rats with XSYWW showed that XSYWW has protective effect against ethanol-induced gastric mucosal lesion. However, there was a faster and more complete healing process in the ranitidine treated group when compared to the XSYWW treated subjects.

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