scholarly journals Autoimmune diseases of oral cavity

2011 ◽  
Vol 2 (2) ◽  
pp. 113-136 ◽  
Author(s):  
Davide B. Gissi ◽  
Mattia Venturi ◽  
Andrea Gabusi ◽  
Annachiara De Martino ◽  
Lucio Montebugnoli
Keyword(s):  
Oral Mucosa ◽  
Pemphigus Vulgaris ◽  
Definitive Diagnosis ◽  
Recurrent Aphthous Stomatitis ◽  
Accurate Diagnosis ◽  
Mucous Membrane Pemphigoid ◽  
Oral Manifestations ◽  
Therapeutic Approaches ◽  
Intercellular Adhesion Molecules ◽  
Bullous Diseases

Most diseases of oral mucosa are either autoimmune in nature or are the results of immunologically-mediated events. These include Recurrent Aphthous Stomatitis (RAS), Erythema Multiforme (EM), the bullous diseases Pemphigus Vulgaris (PV) and Mucous Membrane Pemphigoid (MMP) and Lichen Planus (LP). These conditions are characterised by lesions of the oral mucosa often associated with extra-oral manifestations that include skin, eyes, nasal and pharyngeal mucosa as well as genitals. Despite a similar pathogenesis, they are characterised by different immunologic processes that involve T-cell mediated hypersensitivity in LP, humoral-mediated immunity to cadherin intercellular adhesion molecules in PV, antibody-mediated processes giving rise to junctional separation in MMP, and other not yet completely understood processes in RAS and EM. Differences are also present in the clinical outcome, that is always acute and auto-limiting in EM, auto-limiting and often recurrent in RAS, sub-acute and often recurrent in MMP and PV and always chronic in LP. Accurate diagnosis is not always possible solely on the basis of the oral presentation, and histological and often immunofluorescence examinations are needed in order to establish a definitive diagnosis. The condition that brings together all these diseases is that thay all benefit from similar therapeutic approaches, consisting in local or systemic immunosuppressive treatments. This review provides guidance to differentiate and correctly diagnose these conditions and discusses the most appropriate management.

scholarly journals Optical coherence tomography imaging of oral mucosa bullous diseases: a preliminary study

2020 ◽  
Vol 49 (2) ◽  
pp. 20190071
Author(s):  
Dario Di Stasio ◽  
Dorina Lauritano ◽  
Francesca Loffredo ◽  
Enrica Gentile ◽  
Fedora Della Vella ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Oral Mucosa ◽  
Statistical Power ◽  
Pemphigus Vulgaris ◽  
Invasive Technique ◽  
Optical Coherence ◽  
Non Invasive ◽  
Bullous Diseases ◽  
Subepithelial Layer

Objectives: Optical coherence tomography (OCT) is a non-invasive technique based on optical imaging with a micrometre resolution. The purpose of this study is to investigate the potential role of OCT in evaluating oral mucosa bullous diseases. Methods: two patients with bullous pemphigoid (BP) and one patient with pemphigus vulgaris (PV) were examined and images of their oral lesions were performed using OCT. Results: In OCT images, the BP blister has a clearly different morphology from the PV one compared to the blistering level. Conclusion: This exploratory study suggests that the OCT is able to distinguish epithelial and subepithelial layer in vivo images of healthy oral mucosa from those with bullous diseases, assisting the clinicians in differential diagnosis.The presented data are in accordance with the scientific literature, although a wider pool of cases is needed to increase statistical power. Histological examination and immunofluorescence methods remain the gold standard for the diagnosis of oral bullous diseases. In this context, the OCT can provide the clinician with a valuable aid both as an additional diagnostic tool and in the follow up of the disease.

scholarly journals Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Matteo Saccucci ◽  
Gabriele Di Carlo ◽  
Maurizio Bossù ◽  
Francesca Giovarruscio ◽  
Alessandro Salucci ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Lupus Erythematosus ◽  
Treatment Strategies ◽  
Decisive Role ◽  
Pemphigus Vulgaris ◽  
Mucous Membrane Pemphigoid ◽  
Oral Manifestations ◽  
Specific Knowledge ◽  
Oral Presentations

Oral signs are frequently the first manifestation of autoimmune diseases. For this reason, dentists play an important role in the detection of emerging autoimmune pathologies. Indeed, an early diagnosis can play a decisive role in improving the quality of treatment strategies as well as quality of life. This can be obtained thanks to specific knowledge of oral manifestations of autoimmune diseases. This review is aimed at describing oral presentations, diagnosis, and treatment strategies for systemic lupus erythematosus, Sjögren syndrome, pemphigus vulgaris, mucous membrane pemphigoid, and Behcet disease.

Differential Diagnosis of Superficial Ulcerations of the Oral Mucosa

1979 ◽  
Vol 87 (6) ◽  
pp. 734-740 ◽  
Author(s):  
Richard A. Chole ◽  
George H. Domb
Keyword(s):  
Differential Diagnosis ◽  
Oral Mucosa ◽  
Verrucous Carcinoma ◽  
Pemphigus Vulgaris ◽  
The Body ◽  
Stevens Johnson Syndrome ◽  
Mucous Membrane Pemphigoid ◽  
Diagnostic Challenge ◽  
Johnson Syndrome ◽  
Herpetic Gingivostomatitis

Superficial ulcerations of the oral mucosa often present a diagnostic challenge to the physician because of the similarity of one ulcer to another. A diagnosis is made by the analysis of multiple factors, including the lesion's location, size, grouping, onset, patient's age, involvement of other systems of the body, and course of the disease. The histopathology of the lesion may be specific, especially in certain potentially fatal diseases. This paper presents the means for the differential diagnosis of a variety of superficial ulcers of the oral mucosa: varicella, herpangina, recurrent aphthous stomatitis, Behcet's disease, Stevens-Johnson syndrome, traumatic ulcer, verrucous carcinoma, primary herpetic gingivostomatitis, recurrent herpetic stomatitis, pemphigus vulgaris, and benign mucous membrane pemphigoid.

An Overview of Vesicobullous Conditions Affecting the Oral Mucosa

2016 ◽  
Vol 5 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Emma Hayes ◽  
Stephen J Challacombe
Keyword(s):  
Learning Outcomes ◽  
Oral Mucosa ◽  
Clinical Presentation ◽  
Pemphigus Vulgaris ◽  
Basement Membrane Zone ◽  
Mucous Membrane Pemphigoid ◽  
Specific Reference ◽  
Common Presentation ◽  
The Common

Vesicobullous diseases are characterised by the presence of vesicles or bullae at varying locations in the mucosa. The most common occurring in the oral cavity are mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV). Both are autoimmune diseases with a peak age onset of over 60 years and females are more commonly affected than men. This paper reviews the structure of the oral mucosa, with specific reference to the basement membrane zone, as well as bullous conditions affecting the mucosa, including PV and pemphigoid, their aetiology, clinical presentation, and management. Learning outcomes • Understand the common presentation of vesicobullous diseases. • Appreciate the role of investigations in diagnosis and its interpretation. • Appreciate the roles of both primary and secondary care in patient management.

Familial pemphigus vulgaris with oral manifestations affecting two Greek families

1989 ◽  
Vol 18 (1) ◽  
pp. 49-53 ◽  
Author(s):  
G. Laskaris ◽  
A. Sklavounou ◽  
A. Stavrou ◽  
K. Stavropoulou
Keyword(s):  
Pemphigus Vulgaris ◽  
Oral Manifestations

scholarly journals RECURRENT APHTHOUS STOMATITIS RELATED TO PSYCHOLOGICAL STRESS, FOOD ALLERGY AND GERD

2019 ◽  
Vol 6 ◽  
pp. 45
Author(s):  
Rina Kartika Sari ◽  
Diah Savitri Ernawati ◽  
Bagus Soebadi
Keyword(s):  
Food Allergy ◽  
Psychological Stress ◽  
Oral Mucosa ◽  
Recurrent Aphthous Stomatitis ◽  
Predisposing Factors ◽  
Aphthous Stomatitis ◽  
Cow Milk ◽  
Esophageal Mucosa ◽  
History Of ◽  
Multiple Ulcers

Background: Recurrent Aphthous Stomatitis (RAS) is inflammation in oral mucosa characterized by recurrent single or multiple ulcers that usually affected in non keratinized mucosa. Etiology RAS is unknown but psychological stress, allergy, and gastrointestinal disease can be predisposing factors Case Management: A 23rd years old complained recurrent oral ulcer with free ulcer period for 3-5 days. The patient had a history of food allergy, GERD and psychological stress. Intraoral examination showed recurrent multiple ulcers in variation site of the mouth. DASS 42 screening showed high stress and high anxiety. Skin Prick Test showed positive allergy to kapok, beef, chicken, cow milk, white egg, duck egg, shrimp, cob fish, milkfish, chocolate, and peanut. Ulcers treated with nonsteroid antiinflammation Aloe Vera gel and stress management by reading assignment method.Discussion: Psychological stress altered the immune system so oral mucosa prone to inflammation, and make the history of GERD getting worse. Stress causes cortisol secretion that changes the imbalance of proinflammatory and antiinflammatory cytokines. Oral mucosa becomes more susceptible to hypersensitivity. In addition, stress decreased oral and esophageal mucosa resistance to GERDConclusion: RAS triggered by psychological stress, allergy, and GERD. Treatment of RAS is by elimination predisposing factors to prevent recurrence.

scholarly journals The research of the state of prosthetic bed tissues in patients with pemphigus vulgaris.

2017 ◽  
Vol 23 (1) ◽  
Author(s):  
Bohdan Lyubomyrovych Henyk ◽  
Mykola Mykhaylovych Rozko
Keyword(s):  
Survey Data ◽  
Oral Mucosa ◽  
Clinical Examination ◽  
Comparative Evaluation ◽  
Objective Assessment ◽  
Pemphigus Vulgaris ◽  
The State ◽  
Control Group

The clinical examination of condition of tissues prosthetic bed was conducted in 20 patients with  pemphigus vulgaris. The results are compared with survey data of 20 persons of control group without somatic pathology. It was conducted the analyzes of subjective and objective assessment of tissues prosthetic bed, the results of clinical examination and frequency of various pathologies of the oral mucosa membrane in the studied groups, conducted the comparative evaluation of dental indicators.

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