scholarly journals Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Matteo Saccucci ◽  
Gabriele Di Carlo ◽  
Maurizio Bossù ◽  
Francesca Giovarruscio ◽  
Alessandro Salucci ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Lupus Erythematosus ◽  
Treatment Strategies ◽  
Decisive Role ◽  
Pemphigus Vulgaris ◽  
Mucous Membrane Pemphigoid ◽  
Oral Manifestations ◽  
Specific Knowledge ◽  
Oral Presentations

Oral signs are frequently the first manifestation of autoimmune diseases. For this reason, dentists play an important role in the detection of emerging autoimmune pathologies. Indeed, an early diagnosis can play a decisive role in improving the quality of treatment strategies as well as quality of life. This can be obtained thanks to specific knowledge of oral manifestations of autoimmune diseases. This review is aimed at describing oral presentations, diagnosis, and treatment strategies for systemic lupus erythematosus, Sjögren syndrome, pemphigus vulgaris, mucous membrane pemphigoid, and Behcet disease.

scholarly journals Profil lesi oral pada penderita penyakit autoimun

2016 ◽  
Vol 2 (3) ◽  
pp. 147
Author(s):  
Indah Suasani Wahyuni ◽  
Tenny Setiana Dewi ◽  
Erna Herawati ◽  
Dewi Zakiawati
Keyword(s):  
Quality Of Life ◽  
Autoimmune Diseases ◽  
Lichen Planus ◽  
Lupus Erythematosus ◽  
Oral Lichen Planus ◽  
Pemphigus Vulgaris ◽  
Clinical Feature ◽  
Oral Lesions ◽  
Oral Lichen

Oral lesion’s profi le in autoimmune disease. Oral lesions are commonly found in patients with autoimmune diseases as manifestations of the disease or a side effect of the treatment. Oral lesions must be handled properly to prevent secondary infection, relieve pain and improve the patient’s quality of life. The aim of this study is to describe oral lesions profile in patients with autoimmune diseases, including clinical characteristics and location of oral lesions as well as the distribution of age and sex of the patient. The methods were retrospective observation by describing the secondary data from patients with autoimmune handled by Oral Medicine Specialist, Faculty of Dentistry, University of Padjadjaran in dr. Hasan Sadikin Hospital Dental Clinic. Patient files from August 2010 untill August 2014 (n = 66) were used, with the most often diagnosis were Systemic Lupus erythematosus (SLE), Oral lichen planus (OLP) and Pemphigus vulgaris (PV). It is revealed that, the age of patients varied between 9 to 68 years old and there was predominance of female patients. Patients diagnosed with SLE were 26 (39.4%), 12 patients with OLP (18.2%) and 28 patients with PV (42.4%). Based on the clinical feature, the most commonly found type of oral lesion was erosion (n=52/78,8%), while the most commonly predilection was in the buccal mucosa (n = 46/69,7%). In conclusion, intra-oral examination should be used as a routine procedure in the comprehensive management of patients with autoimmune diseases. Dentist have a professional role in the diagnosis of oral lesions and provide appropriate therapy in order to improve the quality of life of patients with autoimmune diseases.ABSTRAKLesi oral biasa ditemukan pada penderita penyakit autoimun sebagai manifestasi penyakit atau efek samping pengobatan kortikosteroid jangka panjang. Lesi oral harus ditangani dengan baik untuk mencegah terjadinya infeksi sekunder, mengatasi rasa sakit dan meningkatkan kualitas hidup penderita. Pengumpulan data gambaran profil lesi oral penderita penyakit autoimun, meliputi karakteristik klinis dan lokasi lesi oral serta distribusi usia dan jenis kelamin penderita belum pernah dilakukan. Metode yang digunakan adalah non eksperimen, retrospektif dan deskripsi data sekunder penderita autoimun yang ditangani oleh bagian Ilmu Penyakit Mulut FKG Universitas Padjadjaran di SMF Gigi dan Mulut RS dr. Hasan Sadikin Bandung. Data pasien yang dipergunakan antara bulan Agustus 2010 sampai Agustus 2014 (n=66), dengan diagnosis penyakit autoimun yang paling sering adalah Sistemic Lupus Erythematous (SLE), Oral Lichen Planus  (OLP) dan Pemphigus Vulgaris (PV). Semua pasien memberikan persetujuan pada saat dilakukan pemeriksaan dan  pengumpulan data melalui informed consent. Hasil penelitian ini menunjukkan usia penderita bervariasi antara 9 hingga 68 tahun dan jumlah penderita wanita lebih banyak daripada pria. Penderita yang didiagnosis SLE 26 orang (39,4%), OLP 12 orang (18,2%) dan PV 28 orang (42,4%). Berdasarkan gambaran klinisnya jenis lesi oral yang banyak ditemukan adalah erosi (n = 52/ 78,8%) dan berdasarkan lokasi lesi oral banyak ditemukan pada mukosa bukal (n = 46/69,7% penderita). Kesimpulannya, pemeriksaan intra oral disarankan menjadi prosedur rutin dalam tatalaksana komprehensif penderita penyakit autoimun. Dokter gigi diharapkan dapat berperan dalam mendiagnosis lesi oral dan memberikan terapi yang tepat sehingga dapat meningkatkan kualitas hidup penderita penyakit autoimun. 

scholarly journals PÊNFIGO VULGAR A IMPORTÂNCIA DO CONHECIMENTO DO CIRURGIÃO DENTISTA PARA UM CORRETO DIAGNÓSTICO

2015 ◽  
Vol 5 (3) ◽  
Author(s):  
Deyvid Silva Rebouças ◽  
Lucas Souza Cerqueira ◽  
Tila Fortuna Costa ◽  
Thaise Gomes Ferreira ◽  
Roberta Catapano Naves ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Early Diagnosis ◽  
Autoimmune Diseases ◽  
Female Patient ◽  
Clinical Case ◽  
Pemphigus Vulgaris ◽  
Primary Role ◽  
Oral Manifestations ◽  
Early Stages ◽  
Mucous Membranes

Pemphigus is the general name for a group of rare autoimmune diseases that affect the skin and mucous membranes and is presented with the formation of intraepidermal blisters. Pemphigus vulgaris (PV) is a chronic rare vesicular-bullous autoimmune disease that when not diagnosed and treated in its early stages has severe prognosis. This study aims to report a clinical case of a female patient, 32 years of age who had manifestation of pemphigus vulgaris. The oral manifestations are, in most cases, the first signs of the disease and the dentist has a primary role in the early diagnosis.

scholarly journals Autoimmune diseases of oral cavity

2011 ◽  
Vol 2 (2) ◽  
pp. 113-136 ◽  
Author(s):  
Davide B. Gissi ◽  
Mattia Venturi ◽  
Andrea Gabusi ◽  
Annachiara De Martino ◽  
Lucio Montebugnoli
Keyword(s):  
Oral Mucosa ◽  
Pemphigus Vulgaris ◽  
Definitive Diagnosis ◽  
Recurrent Aphthous Stomatitis ◽  
Accurate Diagnosis ◽  
Mucous Membrane Pemphigoid ◽  
Oral Manifestations ◽  
Therapeutic Approaches ◽  
Intercellular Adhesion Molecules ◽  
Bullous Diseases

Most diseases of oral mucosa are either autoimmune in nature or are the results of immunologically-mediated events. These include Recurrent Aphthous Stomatitis (RAS), Erythema Multiforme (EM), the bullous diseases Pemphigus Vulgaris (PV) and Mucous Membrane Pemphigoid (MMP) and Lichen Planus (LP). These conditions are characterised by lesions of the oral mucosa often associated with extra-oral manifestations that include skin, eyes, nasal and pharyngeal mucosa as well as genitals. Despite a similar pathogenesis, they are characterised by different immunologic processes that involve T-cell mediated hypersensitivity in LP, humoral-mediated immunity to cadherin intercellular adhesion molecules in PV, antibody-mediated processes giving rise to junctional separation in MMP, and other not yet completely understood processes in RAS and EM. Differences are also present in the clinical outcome, that is always acute and auto-limiting in EM, auto-limiting and often recurrent in RAS, sub-acute and often recurrent in MMP and PV and always chronic in LP. Accurate diagnosis is not always possible solely on the basis of the oral presentation, and histological and often immunofluorescence examinations are needed in order to establish a definitive diagnosis. The condition that brings together all these diseases is that thay all benefit from similar therapeutic approaches, consisting in local or systemic immunosuppressive treatments. This review provides guidance to differentiate and correctly diagnose these conditions and discusses the most appropriate management.

scholarly journals Contemporary aspects on the immunopathogenesis of autoimmune diseases of the epidermal basement membrane in the dog

2017 ◽  
Vol 56 (1) ◽  
pp. 27
Author(s):  
E. I. PAPADOGIANNAKIS (E. Ι. ΠΑΠΑΔΟΓΙΑΝΝΑΚΗΣ)
Keyword(s):  
Basement Membrane ◽  
Autoimmune Diseases ◽  
Lupus Erythematosus ◽  
Skin Diseases ◽  
Clinical Signs ◽  
Molecular Techniques ◽  
Mucous Membrane Pemphigoid ◽  
Linear Iga Dermatosis ◽  
Specific Antigens ◽  
Epidermal Basement Membrane

Autoimmune diseases of the epidermal basement membrane are the result of the immune system self-activation against specific antigens of its essential structural elements. This group of skin diseases is characterized by the destruction of connecting bonds between the membrane zone and dermis, which eventually leads to the dermoepidermal separation and the formation of subepidermal vesicles and bullae. In this article, the immunopathogenesis and the clinical, histopathological and immunohistochemical features of each of these skin diseases are briefly reviewed. The autoimmune diseases of the canine epidermal basement membrane have been recently classified as bullous pemphigoid, mucous membrane pemphigoid, linear IgA dermatosis, epidermolysis bullosa acquisita and bullous systemic lupus erythematosus. Recent advances in immunopathological and molecular techniques have markedly facilitated the understanding of their pathogenesis, thus giving the opportunity for the development of new therapeutic strategies that may improve or eliminate the clinical signs.

scholarly journals IgM Deficiency in Autoimmune Blistering Mucocutaneous Diseases Following Various Treatments: Long Term Follow-Up and Relevant Observations

2021 ◽  
Vol 12 ◽  
Author(s):  
A. Razzaque Ahmed ◽  
Merve Aksoy
Keyword(s):  
Autoimmune Diseases ◽  
Pemphigus Vulgaris ◽  
Mucous Membrane Pemphigoid ◽  
Pemphigus Foliaceus ◽  
Ocular Cicatricial Pemphigoid ◽  
Long Term Follow Up ◽  
Health And Disease ◽  
Igm Deficiency

IgM deficiency has been reported in patients with many autoimmune diseases treated with Rituximab (RTX). It has not been studied, in detail, in autoimmune mucocutaneous blistering diseases (AIMBD). Our objectives were: (i) Examine the dynamics of IgM levels in patients with and without RTX. (ii) Influence of reduced serum IgM levels on clinical and laboratory parameters. (iii) Explore the possible molecular and cellular basis for reduced serum IgM levels. This retrospective study that was conducted in a single-center from 2000 to 2020. Serial IgM levels were studied in 348 patients with five AIMBD (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, mucous membrane pemphigoid, and ocular cicatricial pemphigoid) and found decreased in 55 patients treated with RTX, IVIG, and conventional immunosuppressive therapy (CIST). Hence the incidence of decreased serum IgM is low. The incidence of decreased IgM in patients treated with RTX was 19.6%, in patients treated with IVIG and CIST, it was 52.8% amongst the 55 patients. IgM levels in the post-RTX group were statistically significantly different from the IVIG group (p<0.018) and CIST group (p<0.001). There were no statistically significant differences between the groups in other clinical and laboratory measures. Decreased serum IgM did not affect depletion or repopulation of CD19+ B cells. Patients in the three groups achieved clinical and serological remission, in spite of decreased IgM levels. Decrease in IgM was isolated, since IgG and IgA were normal throughout the study period. Decreased IgM persisted at the same level, while the patients were in clinical remission, for several years. In spite of persistent decreased IgM levels, the patients did not develop infections, tumors, other autoimmune diseases, or warrant hospitalization. Studies on IgM deficiency in knockout mice provided valuable insights. There is no universally accepted mechanism that defines decreased IgM levels in AIMBD. The data is complex, multifactorial, sometimes contradictory, and not well understood. Nonetheless, data in this study provides novel information that enhances our understanding of the biology of IgM in health and disease.

Clinical evaluation of oral lesions associated with dermatologic diseases

2013 ◽  
Vol 9 (1) ◽  
Author(s):  
Bhawandeep Kaur ◽  
Soheyl Sheikh
Keyword(s):  
Lichen Planus ◽  
Lupus Erythematosus ◽  
Early Stage ◽  
Pemphigus Vulgaris ◽  
Cross Sectional Study ◽  
Routine Practice ◽  
Oral Manifestations ◽  
Cross Sectional ◽  
Dermatology Department ◽  
Adequate Treatment

Introduction: Dermatologic diseases are not only represented by lesions affecting the skin but also by manifestations that may involve the mucous membranes, including oral mucosa. Objectives: To assess the frequency of oral manifestations associated with dermatologic diseases considering the location and clinical characteristics of the lesions found and also gender and age of the patients. Materials and Methods: It was an observational, cross-sectional study of patients who sought for treatment in the Dermatology Department of M. M. College of Medical Sciences & Research, Haryana (n=88). Results: The age of the patients varied from 5 to 88 and there was predominance of female patients. Of the cases studied, 35% were diagnosed as lichen planus, 11% as lupus erythematosus, 13% as erythema multiforme, 30% as pemphigus vulgaris and 11% as of pemphigoid group. Oral manifestations were more common among patients suffering from lichen planus (51%) and pemphigus vulgaris (23%). The most common clinical presentation found was reticular lichen planus located most predominantly in the buccal mucosa. Conclusions: It is essential for the dentists to know these pathologies so that they should be able to diagnose them at an early stage of the disease and direct the patients to get adequate treatment. Furthermore, intra-oral examination should be included as a routine practice in dermatological services.

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