scholarly journals Three-dimensional colon cancer organoids model the response to CEA-CD3 T-cell engagers

Theranostics ◽  
2022 ◽  
Vol 12 (3) ◽  
pp. 1373-1387
Author(s):  
Alvaro Teijeira ◽  
Itziar Migueliz ◽  
Saray Garasa ◽  
Vaios Karanikas ◽  
Carlos Luri ◽  
...  
Keyword(s):  
Colon Cancer ◽  
T Cell ◽  
Three Dimensional

scholarly journals Expression of ROR t Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer

2012 ◽  
Vol 4 (164) ◽  
pp. 164ra159-164ra159 ◽  
Author(s):  
N. R. Blatner ◽  
M. F. Mulcahy ◽  
K. L. Dennis ◽  
D. Scholtens ◽  
D. J. Bentrem ◽  
...  
Keyword(s):  
Colon Cancer ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Subset ◽  
Human Colon ◽  
Human Colon Cancer ◽  
T Cell Subset

Cost-Effective High-Speed, Three-Dimensional Live-Cell Imaging of HIV-1 Transfer at the T Cell Virological Synapse

2021 ◽  
Author(s):  
Alice Sandmeyer ◽  
Lili Wang ◽  
Wolfgang Hübner ◽  
Marcel Müller ◽  
Benjamin Chen ◽  
...  
Keyword(s):  
T Cell ◽  
Live Cell Imaging ◽  
High Speed ◽  
Cell Imaging ◽  
Three Dimensional ◽  
Cost Effective ◽  
Live Cell ◽  
Virological Synapse ◽  
Hiv 1

scholarly journals Single-Cell Analysis Reveals Characterization of Infiltrating T Cells in Moderately Differentiated Colorectal Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Xi Yang ◽  
Quan Qi ◽  
Yuefen Pan ◽  
Qing Zhou ◽  
Yinhang Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Colon Cancer ◽  
T Cells ◽  
T Cell ◽  
Single Cell ◽  
Peripheral Blood ◽  
Strong Correlation ◽  
Tumor Tissue ◽  
Cell Populations

ObjectiveThis study aimed to characterize the tumor-infiltrating T cells in moderately differentiated colorectal cancer.MethodsUsing single-cell RNA sequencing data of isolated 1632 T cells from tumor tissue and 1252 T cells from the peripheral blood of CRC patients, unsupervised clustering analysis was performed to identify functionally distinct T cell populations, followed by correlations and ligand-receptor interactions across cell types. Finally, differential analysis of the tumor-infiltrating T cells between colon cancer and rectal cancer were carried out.ResultsA total of eight distinct T cell populations were identified from tumor tissue. Tumor-Treg showed a strong correlation with Th17 cells. CD8+TRM was positively correlated with CD8+IEL. Seven distinct T cell populations were identified from peripheral blood. There was a strong correlation between CD4+TN and CD4+blood-TCM. Colon cancer and rectal cancer showed differences in the composition of tumor-infiltrating T cell populations. Tumor-infiltrating CD8+IEL cells were found in rectal cancer but not in colon cancer, while CD8+ TN cells were found in the peripheral blood of colon cancer but not in that of rectal cancer. A larger number of tumor-infiltrating CD8+ Tex (88.94%) cells were found in the colon cancer than in the rectal cancer (11.06%). The T cells of the colon and rectal cancers showed changes in gene expression pattern.ConclusionsWe characterized the T cell populations in the CRC tumor tissue and peripheral blood.

scholarly journals Protein Kinase D1 attenuates tumorigenesis in colon cancer by modulating β-catenin/T cell factor activity

Oncotarget ◽  
2014 ◽  
Vol 5 (16) ◽  
pp. 6867-6884 ◽  
Author(s):  
Vasudha Sundram ◽  
Aditya Ganju ◽  
Joshua E. Hughes ◽  
Sheema Khan ◽  
Subhash C. Chauhan ◽  
...  
Keyword(s):  
Colon Cancer ◽  
T Cell ◽  
Protein Kinase ◽  
Factor Activity ◽  
Protein Kinase D1 ◽  
T Cell Factor

scholarly journals T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth

2017 ◽  
Vol 6 (4) ◽  
pp. e1302631 ◽  
Author(s):  
Else M. Inderberg ◽  
Sébastien Wälchli ◽  
Marit R. Myhre ◽  
Sissel Trachsel ◽  
Hilde Almåsbak ◽  
...  
Keyword(s):  
Colon Cancer ◽  
T Cell ◽  
Cell Therapy ◽  
Tumor Growth ◽  
T Cell Therapy

scholarly journals The role of galectin-1 and galectin-3 in the mechanisms of T-cell immune response dysregulation in colon cancer

2020 ◽  
Vol 19 (3) ◽  
pp. 76-82
Author(s):  
V. S. Poletika ◽  
Yu. V. Kolobovnikova ◽  
O. I. Urazova ◽  
O. A. Vasileva ◽  
A. I. Dmitrieva ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Immune Response ◽  
T Cell ◽  
Cell Immune Response ◽  
Galectin 3

VEGFR2 expressions in Th1 and CD8+ cytotoxic T lymphocytes (CTL) in colon cancer patients.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e15535-e15535
Author(s):  
Mehmet Artac ◽  
Ayca Ceylan ◽  
Melek Karakurt Eryılmaz ◽  
Murat Araz ◽  
Mustafa Karaagac ◽  
...  
Keyword(s):  
Colon Cancer ◽  
T Cell ◽  
Cancer Patients ◽  
Study Groups ◽  
T Cell Subsets ◽  
Control Group ◽  
Study Group ◽  
Metastatic Colon Cancer ◽  
Vegf Receptors ◽  
Cancer History

e15535 Background: VEGF receptors have an important role for inhibiting adaptive immun response in colon cancer. Therefore, we analyzed VEGF receptors in circulating T cell subsets according to stage in colon cancer patients. Methods: The prospective study group consisted of 50 patients with histologically confirmed colon cancer and 30 person without any cancer history as a control group. Peripheral blood specimens were collected from the patients after the diagnosis before inducing chemotherapy and radiotherapy. Patients with active infections or autoimmune disorders, who were treated with steroids and antibiotics in the last four weeks before the study enrollment were excluded from the study group. VEGFR2 expressions in circulating T cell subsets (Th1, Th2, Th17, CTL) were analyzed by flow cyctometry. Results: Age and gender were not different between the all study groups. Mean circulating CD4+ folicullar cells were less in colon cancer patients (9.54%±3.99) than the control group (12.03%±4.34), (p < 0.01). Mean circulating CD8+ follicular cells were higher in metastatic colon cancer (n = 26) 2.48% ± 1.68, than the non-metastatic colon cancer patients (n = 24) 1.63% ± 1.37, (p = 0.02). Mean VEGFR2 expressions in Th1 cells were higher in colon cancer patients 248.8 (Mean Flourescein intensity-MFI) than the control group 224.6, (P = 0.006). Mean VEGFR2 expressions in CTL were higher in colon cancer patients (381.8) than the control group (284.7), (p < 0.001). PD-1 expressions were not different between the colon cancer patients and the control group in all circulating T cell subsets. Mean VEGFR2 expressions in Th17 cells were higher non-metastatic colon cancer patients than the metastatic colon cancer patients (326.5 and 268.4 MFI, respectively, p = 0.02). Conclusions: VEGFR2 expressions are increased in circulating Th1 and CTL subsets in colon cancer patients. Whereas PD-1 expressions were not different in circulating T cell subsets than the control. VEGFRs may play an important role for the inhibition of circulating T cell subsets in colon cancer.

scholarly journals Cutting Edge: The Tumor Counterattack Hypothesis Revisited: Colon Cancer Cells Do Not Induce T Cell Apoptosis Via the Fas (CD95, APO-1) Pathway

2000 ◽  
Vol 164 (10) ◽  
pp. 5023-5027 ◽  
Author(s):  
Nathalie Favre-Felix ◽  
Annie Fromentin ◽  
Arlette Hammann ◽  
Eric Solary ◽  
François Martin ◽  
...  
Keyword(s):  
Colon Cancer ◽  
T Cell ◽  
Cancer Cells ◽  
Cell Apoptosis ◽  
Cutting Edge ◽  
Colon Cancer Cells ◽  
T Cell Apoptosis
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