scholarly journals Early administration of MPC-n(IVIg) selectively accumulates in ischemic areas to protect inflammation-induced brain damage from ischemic stroke

Theranostics ◽  
2021 ◽  
Vol 11 (17) ◽  
pp. 8197-8217
Author(s):  
Weili Jin ◽  
Ye Wu ◽  
Ning Chen ◽  
Qixue Wang ◽  
Yunfei Wang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Brain Damage ◽  
Early Administration

scholarly journals Development of a photochemical thrombosis investigation system to obtain a rabbit ischemic stroke model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yoonhee Kim ◽  
Yoon Bum Lee ◽  
Seung Kuk Bae ◽  
Sung Suk Oh ◽  
Jong-ryul Choi
Keyword(s):  
Ischemic Stroke ◽  
Brain Damage ◽  
Rabbit Model ◽  
Specific Area ◽  
Brain Atlas ◽  
Rabbit Brain ◽  
Stroke Model ◽  
Triphenyltetrazolium Chloride ◽  
Induction System

AbstractPhotochemical thrombosis is a method for the induction of ischemic stroke in the cerebral cortex. It can generate localized ischemic infarcts in the desired region; therefore, it has been actively employed in establishing an ischemic stroke animal model and in vivo assays of diagnostic and therapeutic techniques for stroke. To establish a rabbit ischemic stroke model and overcome the shortcoming of previous studies that were difficult to build a standardized photothrombotic rabbit model, we developed a photochemical thrombosis induction system that can produce consistent brain damage on a specific area. To verify the generation of photothrombotic brain damage using the system, longitudinal magnetic resonance imaging, 2,3,5-triphenyltetrazolium chloride staining, and histological staining were applied. These analytical methods have a high correlation for ischemic infarction and are appropriate for analyzing photothrombotic brain damage in the rabbit brain. The results indicated that the photothrombosis induction system has a main advantage of being accurately controlled a targeted region of photothrombosis and can produce cerebral hemisphere lesions on the target region of the rabbit brain. In conjugation with brain atlas, it can induce photochemical ischemic stroke locally in the part of the brain that is responsible for a particular brain function and the system can be used to develop animal models with degraded specific functions. Also, the photochemical thrombosis induction system and a standardized rabbit ischemic stroke model that uses this system have the potential to be used for verifications of biomedical techniques for ischemic stroke at a preclinical stage in parallel with further performance improvements.

scholarly journals Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection

Aging Cell ◽  
2013 ◽  
Vol 12 (5) ◽  
pp. 842-850 ◽  
Author(s):  
Hiramani Dhungana ◽  
Tarja Malm ◽  
Adam Denes ◽  
Piia Valonen ◽  
Sara Wojciechowski ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Brain Damage ◽  
Peripheral Infection

Abstract P198: WNK-SPAK-NKCC1 Cascade Activation Contributes to Worsened Brain Damage in Mice With Hypertension Co-Morbidity after Ischemic Stroke

Hypertension ◽  
2018 ◽  
Vol 72 (Suppl_1) ◽  
Author(s):  
Mohammad Iqbal H Bhuiyan ◽  
Huachen Huang ◽  
Ting Zhang ◽  
Bradley J Molyneaux ◽  
Samuel M Poloyac ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Brain Damage ◽  
Co Morbidity

scholarly journals Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice: Ischemia and Reparixin

Clinics ◽  
2013 ◽  
Vol 68 (3) ◽  
pp. 391-394 ◽  
Author(s):  
LF Sousa ◽  
FM Coelho ◽  
DH Rodrigues ◽  
AC Campos ◽  
LS Barcelos ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Brain Damage ◽  
Chemokine Receptors

scholarly journals Glycogenolysis Is Crucial for Astrocytic Glycogen Accumulation and Brain Damage after Reperfusion in Ischemic Stroke

iScience ◽  
2020 ◽  
Vol 23 (5) ◽  
pp. 101136 ◽  
Author(s):  
Yanhui Cai ◽  
Haiyun Guo ◽  
Ze Fan ◽  
Xinlei Zhang ◽  
Di Wu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Brain Damage ◽  
Glycogen Accumulation

scholarly journals Amplification of Regulatory T Cells Using a CD28 Superagonist Reduces Brain Damage After Ischemic Stroke in Mice

Stroke ◽  
2015 ◽  
Vol 46 (1) ◽  
pp. 212-220 ◽  
Author(s):  
Shin-Young Na ◽  
Eva Mracsko ◽  
Arthur Liesz ◽  
Thomas Hünig ◽  
Roland Veltkamp
Keyword(s):  
T Cells ◽  
Ischemic Stroke ◽  
Regulatory T Cells ◽  
Brain Damage

Pre-ischemic treadmill training alleviates brain damage via GLT-1-mediated signal pathway after ischemic stroke in rats

Neuroscience ◽  
2014 ◽  
Vol 274 ◽  
pp. 393-402 ◽  
Author(s):  
X. Wang ◽  
M. Zhang ◽  
S.-D. Yang ◽  
W.-B. Li ◽  
S.-Q. Ren ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Brain Damage ◽  
Signal Pathway ◽  
Treadmill Training

Electroacupuncture Alleviates Brain Damage Through Targeting of Neuronal Calcium Sensor 1 by miR-191a-5p After Ischemic Stroke

2017 ◽  
Vol 20 (6) ◽  
pp. 492-505 ◽  
Author(s):  
Heng Zhou ◽  
Cen Yang ◽  
Fuhai Bai ◽  
Zhi Ma ◽  
Jingyi Wang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Brain Damage ◽  
Calcium Sensor ◽  
Neuronal Calcium Sensor

scholarly journals Anton’s Syndrome due to Bilateral Ischemic Occipital Lobe Strokes

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Sanela Zukić ◽  
Osman Sinanović ◽  
Lejla Zonić ◽  
Renata Hodžić ◽  
Svjetlana Mujagić ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Head And Neck ◽  
Brain Damage ◽  
Visual Loss ◽  
Sensory Input ◽  
Occipital Lobe ◽  
Charles Bonnet Syndrome

We present a case of a patient with Anton’s syndrome (i.e., visual anosognosia with confabulations), who developed bilateral occipital lobe infarct. Bilateral occipital brain damage results in blindness, and patients start to confabulate to fill in the missing sensory input. In addition, the patient occasionally becomes agitated and talks to himself, which indicates that, besides Anton’s syndrome, he might have had Charles Bonnet syndrome, characterized by both visual loss and hallucinations. Anton syndrome, is not so frequent condition and is most commonly caused by ischemic stroke. In this particular case, the patient had successive bilateral occipital ischemia as a result of massive stenoses of head and neck arteries.

Sign in / Sign up

Export Citation Format

Share Document