scholarly journals Circular RNA in pancreatic cancer: a novel avenue for the roles of diagnosis and treatment

Theranostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 2755-2769
Author(s):  
Zeyin Rong ◽  
Jin Xu ◽  
Si Shi ◽  
Zhen Tan ◽  
Qingcai Meng ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Circular Rna ◽  
Diagnosis And Treatment

scholarly journals Recent Advances in the Potential Use of Circular RNA for the Diagnosis and Treatment of Pancreatic Cancer

2021 ◽  
Vol Volume 13 ◽  
pp. 4251-4262
Author(s):  
Xinzhu Sun ◽  
Dongyan Liu ◽  
Nan Ge ◽  
Jintao Guo ◽  
Sheng Wang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Circular Rna ◽  
Diagnosis And Treatment ◽  
Recent Advances ◽  
Potential Use

scholarly journals The significance of exosomal RNAs in the development, diagnosis, and treatment of pancreatic cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zheng Zhao ◽  
Guiping Zhao ◽  
Shuyue Yang ◽  
Shengtao Zhu ◽  
Shutian Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Immune Escape ◽  
Diagnosis And Treatment ◽  
Circular Rnas ◽  
Molecular Heterogeneity ◽  
Bioactive Constituents ◽  
Functional Connections ◽  
Non Coding Rnas ◽  
The Relationship ◽  
Exosomal Rnas

AbstractExosomes are single-membrane, secreted organelles with a diameter of 30–200 nm, containing diverse bioactive constituents, including DNAs, RNAs, proteins, and lipids, with prominent molecular heterogeneity. Extensive studies indicate that exosomal RNAs (e.g., microRNAs, long non-coding RNAs, and circular RNAs) can interact with many types of cancers, associated with several hallmark features like tumor growth, metastasis, and resistance to therapy. Pancreatic cancer (PaCa) is among the most lethal cancers worldwide, emerging as the seventh foremost cause of cancer-related death in both sexes. Hence, revealing the specific pathogenesis and improving the clinical diagnosis and treatment process are urgently required. As the study of exosomes has become an active area of research, the functional connections between exosomes and PaCa have been deeply investigated. Among these, exosomal RNAs seem to play a significant role in the development, diagnosis, and treatment of PaCa. Exosomal RNAs delivery ultimately modulates the various features of PaCa, and many scholars have interpreted how exosomal RNAs contribute to the proliferation, angiogenesis, migration, invasion, metastasis, immune escape, and drug resistance in PaCa. Besides, recent studies emphasize that exosomal RNAs may serve as diagnostic and prognostic biomarkers or therapeutic targets for PaCa. In this review, we will introduce these recent insights focusing on the discoveries of the relationship between exosomal RNAs and PaCa, and the potentially diagnostic and therapeutic applications of exosomes in PaCa.

scholarly journals Guidelines for the Diagnosis and Treatment of Pancreatic Cancer in China (2021)

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Yinmo Yang ◽  
Xueli Bai ◽  
Dapeng Bian ◽  
Shouwang Cai ◽  
Rufu Chen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Diagnosis And Treatment

scholarly journals Application of Mass Spectrometry in Pancreatic Cancer Translational Research

2021 ◽  
Vol 11 ◽  
Author(s):  
Peng Ge ◽  
Yalan Luo ◽  
Haiyang Chen ◽  
Jiayue Liu ◽  
Haoya Guo ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Pancreatic Cancer ◽  
Malignant Tumors ◽  
Basic Research ◽  
Present Situation ◽  
Diagnosis And Treatment ◽  
Research Model ◽  
Comprehensive Diagnosis ◽  
Remarkable Progress ◽  
Made In

Pancreatic cancer (PC) is one of the most common malignant tumors in the digestive tract worldwide, with increased morbidity and mortality. In recent years, with the development of surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, and the change of the medical thinking model, remarkable progress has been made in researching comprehensive diagnosis and treatment of PC. However, the present situation of diagnostic and treatment of PC is still unsatisfactory. There is an urgent need for academia to fully integrate the basic research and clinical data from PC to form a research model conducive to clinical translation and promote the proper treatment of PC. This paper summarized the translation progress of mass spectrometry (MS) in the pathogenesis, diagnosis, prognosis, and PC treatment to promote the basic research results of PC into clinical diagnosis and treatment.

Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer

2018 ◽  
Vol 432 ◽  
pp. 237-250 ◽  
Author(s):  
Zhonghu Li ◽  
Wu Yanfang ◽  
Jie Li ◽  
Peng Jiang ◽  
Tao Peng ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Circular Rna ◽  
Invasive Growth

Cancer statistics: Current diagnosis and treatment of pancreatic cancer in Shanghai, China

2014 ◽  
Vol 346 (2) ◽  
pp. 273-277 ◽  
Author(s):  
Jiang Long ◽  
Guo-pei Luo ◽  
Zhi-wen Xiao ◽  
Zu-qiang Liu ◽  
Meng Guo ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Diagnosis And Treatment ◽  
Cancer Statistics
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