scholarly journals LPA3-mediated lysophosphatidic acid signaling promotes postnatal heart regeneration in mice

Theranostics ◽  
2020 ◽  
Vol 10 (24) ◽  
pp. 10892-10907
Author(s):  
Fang Wang ◽  
Si Liu ◽  
Jianqiu Pei ◽  
Lin Cai ◽  
Ning Liu ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
Heart Regeneration ◽  
Lysophosphatidic Acid Signaling

scholarly journals Blockage of Lysophosphatidic Acid Signaling Improves Spinal Cord Injury Outcomes

2012 ◽  
Vol 181 (3) ◽  
pp. 978-992 ◽  
Author(s):  
Yona Goldshmit ◽  
Rosalia Matteo ◽  
Tamar Sztal ◽  
Felix Ellett ◽  
Frisca Frisca ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Lysophosphatidic Acid ◽  
Cord Injury ◽  
Injury Outcomes ◽  
Lysophosphatidic Acid Signaling

scholarly journals Lysophosphatidic Acid Signaling Axis Mediates Ceramide 1-Phosphate-Induced Proliferation of C2C12 Myoblasts

2018 ◽  
Vol 19 (1) ◽  
pp. 139 ◽  
Author(s):  
Caterina Bernacchioni ◽  
Francesca Cencetti ◽  
Alberto Ouro ◽  
Marina Bruno ◽  
Antonio Gomez-Muñoz ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
C2c12 Myoblasts ◽  
Signaling Axis ◽  
Ceramide 1 ◽  
Lysophosphatidic Acid Signaling

scholarly journals MicroRNA Regulation of the Autotaxin-Lysophosphatidic Acid Signaling Axis

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1369 ◽  
Author(s):  
Mandi M. Murph
Keyword(s):  
Lysophosphatidic Acid ◽  
Current Status ◽  
Mirna Regulation ◽  
Exciting Field ◽  
Microrna Regulation ◽  
Normal Tissues ◽  
Argonaute Proteins ◽  
Signaling Axis ◽  
Lysophosphatidic Acid Signaling ◽  
Lysophosphatidic Acid Receptors

The revelation that microRNAs (miRNAs) exist within the human genome uncovered an underappreciated mechanism of gene expression. For cells to regulate expression of their genes, miRNA molecules and argonaute proteins bind to mRNAs and interfere with efficient translation of the RNA transcript. Although miRNAs have important roles in normal tissues, miRNAs may adopt aberrant functions in malignant cells depending on their classification as either a tumor suppressor or oncogenic miRNA. Within this review, the current status of miRNA regulation is described in the context of signaling through the lysophosphatidic acid receptors, including the lysophosphatidic acid-producing enzyme, autotaxin. Thus far, research has revealed miRNAs that increase in response to lysophosphatidic acid stimulation, such as miR-21, miR-30c-2-3p, and miR-122. Other miRNAs inhibit the translation of lysophosphatidic acid receptors, such as miR-15b, miR-23a, and miR200c, or proteins that are downstream of lysophosphatidic acid signaling, such as miR-146 and miR-21. With thousands of miRNAs still uncharacterized, it is anticipated that the complex regulation of lysophosphatidic acid signaling by miRNAs will continue to be elucidated. RNA-based therapeutics have entered the clinic with enormous potential in precision medicine. This exciting field is rapidly emerging and it will be fascinating to witness its expansion in scope.

Book Review: Neurobiology of Lysophosphatidic Acid Signaling

2002 ◽  
Vol 8 (6) ◽  
pp. 540-550 ◽  
Author(s):  
Nobuyuki Fukushima ◽  
Xiaoqin Ye ◽  
Jerold Chun
Keyword(s):  
Lysophosphatidic Acid ◽  
Lysophosphatidic Acid Signaling

scholarly journals Lysophosphatidic Acid Signaling May Initiate Fetal Hydrocephalus

2011 ◽  
Vol 3 (99) ◽  
pp. 99ra87-99ra87 ◽  
Author(s):  
Y. C. Yung ◽  
T. Mutoh ◽  
M.-E. Lin ◽  
K. Noguchi ◽  
R. R. Rivera ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
Fetal Hydrocephalus ◽  
Lysophosphatidic Acid Signaling

scholarly journals Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization

2016 ◽  
Vol 55 (1) ◽  
pp. 105-116 ◽  
Author(s):  
Manuela Funke ◽  
Lars Knudsen ◽  
David Lagares ◽  
Simone Ebener ◽  
Clemens K. Probst ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
Lysophosphatidic Acid Signaling

Lysophosphatidic acid signaling: how a small lipid does big things

2003 ◽  
Vol 28 (7) ◽  
pp. 377-383 ◽  
Author(s):  
Celine Luquain ◽  
Vicki A Sciorra ◽  
Andrew J Morris
Keyword(s):  
Lysophosphatidic Acid ◽  
Lysophosphatidic Acid Signaling
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