scholarly journals Blockage of Lysophosphatidic Acid Signaling Improves Spinal Cord Injury Outcomes

2012 ◽  
Vol 181 (3) ◽  
pp. 978-992 ◽  
Author(s):  
Yona Goldshmit ◽  
Rosalia Matteo ◽  
Tamar Sztal ◽  
Felix Ellett ◽  
Frisca Frisca ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Lysophosphatidic Acid ◽  
Cord Injury ◽  
Injury Outcomes ◽  
Lysophosphatidic Acid Signaling

scholarly journals LPA receptor signaling as a therapeutic target for radical treatment of neuropathic pain and fibromyalgia

2020 ◽  
Vol 10 (1) ◽  
pp. 43-53 ◽  
Author(s):  
Hiroshi Ueda
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chronic Pain ◽  
Neuropathic Pain ◽  
Lysophosphatidic Acid ◽  
Receptor Signaling ◽  
Acidic Stress ◽  
Wide Spread ◽  
Lpa Receptor ◽  
Cord Injury

Since the first discovery that the bioactive lipid, lysophosphatidic acid (LPA) and LPA1 receptor signaling play a role in the initiation of neuropathic pain (NeuP), accumulated reports have supported the original findings and extended the study toward possible therapeutic applications. The present review describes beneficial roles of LPA receptor signaling in a variety of chronic pain, such as peripheral NeuP induced by nerve injury, chemotherapy and diabetes, central NeuP induced by cerebral ischemia with hemorrhage and spinal cord injury, and fibromyalgia-like wide spread pain induced by repeated cold, psychological and muscular acidic stress. Emerging mechanistic findings are the feed-forward amplification of LPA production through LPA1, LPA3 and microglia and the evidence for maintenance of chronic pain by LPA receptor signaling.

scholarly journals Lysophosphatidic acid receptor type 2 activation contributes to secondary damage after spinal cord injury in mice

2019 ◽  
Vol 76 ◽  
pp. 258-267 ◽  
Author(s):  
Clara López-Serrano ◽  
Eva Santos-Nogueira ◽  
Isaac Francos-Quijorna ◽  
Marina Coll-Miró ◽  
Jerold Chun ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Lysophosphatidic Acid ◽  
Receptor Type ◽  
Acid Receptor ◽  
Lysophosphatidic Acid Receptor ◽  
Secondary Damage ◽  
Cord Injury

scholarly journals Ureteroscopy in patients with spinal cord injury: outcomes from a spinal injury unit and a review of literature

2019 ◽  
Vol 8 (S4) ◽  
pp. S352-S358 ◽  
Author(s):  
Sarah Prattley ◽  
Rachel Oliver ◽  
Francesca New ◽  
Melissa Davies ◽  
James Brewin
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Spinal Injury ◽  
Review Of Literature ◽  
Cord Injury ◽  
Injury Outcomes

Alcohol Intoxication and Its Effects on Traumatic Spinal Cord Injury Outcomes

2014 ◽  
Vol 31 (9) ◽  
pp. 798-802 ◽  
Author(s):  
Clifford L. Crutcher ◽  
Beatrice Ugiliweneza ◽  
Jonathan E. Hodes ◽  
Maiying Kong ◽  
Maxwell Boakye
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Alcohol Intoxication ◽  
Traumatic Spinal Cord Injury ◽  
Cord Injury ◽  
Injury Outcomes

scholarly journals IVIg attenuates complement and improves spinal cord injury outcomes in mice

2016 ◽  
Vol 3 (7) ◽  
pp. 495-511 ◽  
Author(s):  
Faith H. Brennan ◽  
Nyoman D. Kurniawan ◽  
Jana Vukovic ◽  
Perry F. Bartlett ◽  
Fabian Käsermann ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury ◽  
Injury Outcomes
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