scholarly journals LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer

Theranostics ◽  
2020 ◽  
Vol 10 (22) ◽  
pp. 10274-10289 ◽  
Author(s):  
Biao Zheng ◽  
Jianhua Qu ◽  
Kenoki Ohuchida ◽  
Haimin Feng ◽  
Stephen Jun Fei Chong ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome ◽  
High Liver

scholarly journals LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer: Erratum

Theranostics ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 10171-10172
Author(s):  
Biao Zheng ◽  
Jianhua Qu ◽  
Kenoki Ohuchida ◽  
Haimin Feng ◽  
Stephen Jun Fei Chong ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome ◽  
High Liver

scholarly journals Retroperitoneal Extragastrointestinal Stromal Tumors Have a Poor Survival Outcome: A Multicenter Observational Study

2020 ◽  
Vol Volume 12 ◽  
pp. 10491-10504
Author(s):  
Weixian Hu ◽  
Chengbin Zheng ◽  
Renjie Li ◽  
Xingyu Feng ◽  
Guoliang Zheng ◽  
...  
Keyword(s):  
Observational Study ◽  
Survival Outcome ◽  
Poor Survival ◽  
Multicenter Observational Study ◽  
Stromal Tumors ◽  
Poor Survival Outcome

scholarly journals Quantitative hormone receptor (HR) expression and gene expression analysis in HR+ inflammatory breast cancer (IBC) vs non-IBC

2020 ◽  
Author(s):  
Toshiaki Iwase ◽  
Kenichi Harano ◽  
Hiroko Masuda ◽  
Kumiko Kida ◽  
Kenneth R. Hess ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Inflammatory Breast Cancer ◽  
Hormone Receptor ◽  
Survival Outcome ◽  
Stage Iii ◽  
Prognostic Role ◽  
Poor Survival ◽  
Poor Survival Outcome

Abstract Purpose: The purpose of this study was to determine the prognostic role of hormone receptor (HR) on inflammatory breast cancer (IBC) to elucidate its aggressive biological behavior.Methods: We evaluated the expression of estrogen receptor (ER) and progesterone receptor (PR) by immunohistochemical staining and determined the predictive and prognostic role of HR expression on 189 patients with HR+/HER2– IBC and 677 patients with HR+/HER2– stage III non-IBC. Furthermore, we performed gene expression (GE) analyses for 137 patients with HR+/HER2– IBC and 252 patients with corresponding non-IBC to detect genes that are specifically overexpressed in IBC.Results: The expression of ER% was significantly associated with longer distant disease-free survival and overall survival. However, there was no significant relationship between ER% and NAC outcome. In the GE study, 84 genes were identified as significantly distinguishing HR+ IBC from non-IBC. Among the top 15 canonical pathways expressed in IBC, the ERK/MAPK, PDGF, insulin receptor, and IL-7 signaling pathways were associated with the ER signaling pathway. Upregulation of the MYC gene was observed in three of these four pathways. Furthermore, HR+/HER2– IBC had significantly higher MYC amplification, and the genetic alteration was associated with poor survival outcome.Conclusions: Increased HR positivity was significantly associated with improved survival in both HR+/HER2– IBC and HR+/HER2– stage III non-IBC patients. HR+/HER2– IBC had several activated pathways with MYC upregulation, and the genetic alteration was associated with poor survival outcome. The results indicate that MYC may be a key gene for understanding the biology of HR+/HER2– IBC.

scholarly journals Increased expression of microRNA-26a-5p predicted a poor survival outcome in osteosarcoma patients

Medicine ◽  
2021 ◽  
Vol 100 (12) ◽  
pp. e24765
Author(s):  
Xiao-Yu Xie ◽  
Xian-Ming Chen ◽  
Ling Shi ◽  
Jun-Wei Liu
Keyword(s):  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome

scholarly journals Promoter Methylation of CDO1 Identifies Clear-Cell Renal Cell Cancer Patients with Poor Survival Outcome

2015 ◽  
Vol 21 (15) ◽  
pp. 3492-3500 ◽  
Author(s):  
Ivette A.G. Deckers ◽  
Leo J. Schouten ◽  
Leander Van Neste ◽  
Iris J.H. van Vlodrop ◽  
Patricia M.M.B. Soetekouw ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Renal Cell Cancer ◽  
Promoter Methylation ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Cancer ◽  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome

Low expression of SLC22A18 predicts poor survival outcome in patients with breast cancer after surgery

2011 ◽  
Vol 35 (3) ◽  
pp. 279-285 ◽  
Author(s):  
Hongyu He ◽  
Cheng Xu ◽  
Ziqin Zhao ◽  
Xinyu Qin ◽  
Hongmei Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome ◽  
Low Expression
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