scholarly journals Increased expression of senescence markers p14ARFand p16INK4ain breast cancer is associated with an increased risk of disease recurrence and poor survival outcome

2016 ◽  
Vol 69 (3) ◽  
pp. 479-491 ◽  
Author(s):  
Rahmawati Pare ◽  
Joo-Shik Shin ◽  
Cheok Soon Lee
Keyword(s):  
Breast Cancer ◽  
Disease Recurrence ◽  
Survival Outcome ◽  
Poor Survival ◽  
Increased Risk ◽  
Poor Survival Outcome ◽  
Risk Of Disease

scholarly journals Quantitative hormone receptor (HR) expression and gene expression analysis in HR+ inflammatory breast cancer (IBC) vs non-IBC

2020 ◽  
Author(s):  
Toshiaki Iwase ◽  
Kenichi Harano ◽  
Hiroko Masuda ◽  
Kumiko Kida ◽  
Kenneth R. Hess ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Inflammatory Breast Cancer ◽  
Hormone Receptor ◽  
Survival Outcome ◽  
Stage Iii ◽  
Prognostic Role ◽  
Poor Survival ◽  
Poor Survival Outcome

Abstract Purpose: The purpose of this study was to determine the prognostic role of hormone receptor (HR) on inflammatory breast cancer (IBC) to elucidate its aggressive biological behavior.Methods: We evaluated the expression of estrogen receptor (ER) and progesterone receptor (PR) by immunohistochemical staining and determined the predictive and prognostic role of HR expression on 189 patients with HR+/HER2– IBC and 677 patients with HR+/HER2– stage III non-IBC. Furthermore, we performed gene expression (GE) analyses for 137 patients with HR+/HER2– IBC and 252 patients with corresponding non-IBC to detect genes that are specifically overexpressed in IBC.Results: The expression of ER% was significantly associated with longer distant disease-free survival and overall survival. However, there was no significant relationship between ER% and NAC outcome. In the GE study, 84 genes were identified as significantly distinguishing HR+ IBC from non-IBC. Among the top 15 canonical pathways expressed in IBC, the ERK/MAPK, PDGF, insulin receptor, and IL-7 signaling pathways were associated with the ER signaling pathway. Upregulation of the MYC gene was observed in three of these four pathways. Furthermore, HR+/HER2– IBC had significantly higher MYC amplification, and the genetic alteration was associated with poor survival outcome.Conclusions: Increased HR positivity was significantly associated with improved survival in both HR+/HER2– IBC and HR+/HER2– stage III non-IBC patients. HR+/HER2– IBC had several activated pathways with MYC upregulation, and the genetic alteration was associated with poor survival outcome. The results indicate that MYC may be a key gene for understanding the biology of HR+/HER2– IBC.

Low expression of SLC22A18 predicts poor survival outcome in patients with breast cancer after surgery

2011 ◽  
Vol 35 (3) ◽  
pp. 279-285 ◽  
Author(s):  
Hongyu He ◽  
Cheng Xu ◽  
Ziqin Zhao ◽  
Xinyu Qin ◽  
Hongmei Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome ◽  
Low Expression

scholarly journals Quantitative hormone receptor (HR) expression and gene expression analysis in HR+ inflammatory breast cancer (IBC) vs non-IBC

2020 ◽  
Author(s):  
Toshiaki Iwase ◽  
Kenichi Harano ◽  
Hiroko Masuda ◽  
Kumiko Kida ◽  
Kenneth R. Hess ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Inflammatory Breast Cancer ◽  
Hormone Receptor ◽  
Survival Outcome ◽  
Stage Iii ◽  
Prognostic Role ◽  
Poor Survival ◽  
Poor Survival Outcome

Abstract Background: The purpose of this study was to determine the prognostic role of hormone receptor (HR) on inflammatory breast cancer (IBC) to elucidate its aggressive biological behavior.Methods: We evaluated the expression of estrogen receptor (ER) and progesterone receptor (PR) by immunohistochemical staining and determined the predictive and prognostic role of HR expression on 189 patients with HR+/HER2– IBC and 677 patients with HR+/HER2– stage III non-IBC. Furthermore, we performed gene expression (GE) analyses on 137 patients with HR+/HER2– IBC and 252 patients with HR+/HER2– non-IBC to detect genes that are specifically overexpressed in IBC.Results: The expression of ER% was significantly associated with longer distant disease-free survival and overall survival. However, there was no significant relationship between ER% and neoadjuvant chemotherapy outcome. In the GE study, 84 genes were identified as significantly distinguishing HR+ IBC from non-IBC. Among the top 15 canonical pathways expressed in IBC, the ERK/MAPK, PDGF, insulin receptor, and IL-7 signaling pathways were associated with the ER signaling pathway. Upregulation of the MYC gene was observed in three of these four pathways. Furthermore, HR+/HER2– IBC had significantly higher MYC amplification, and the genetic alteration was associated with poor survival outcome.Conclusions: Higher ER expression was significantly associated with improved survival in both HR+/HER2– IBC and HR+/HER2– stage III non-IBC patients. HR+/HER2– IBC had several activated pathways with MYC upregulation, and the genetic alteration was associated with poor survival outcome. The results indicate that MYC may be a key gene for understanding the biology of HR+/HER2– IBC.

scholarly journals Low expression of WWC1 , a tumor suppressor gene, is associated with aggressive breast cancer and poor survival outcome

FEBS Open Bio ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 1270-1280 ◽  
Author(s):  
Zhanwei Wang ◽  
Dionyssios Katsaros ◽  
Nicoletta Biglia ◽  
Yi Shen ◽  
Yuanyuan Fu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome ◽  
Low Expression ◽  
Aggressive Breast Cancer

scholarly journals Low expression of TFPI-2 associated with poor survival outcome in patients with breast cancer

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Cheng Xu ◽  
Huijun Wang ◽  
Hongyu He ◽  
Fengyun Zheng ◽  
Yating Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome ◽  
Low Expression

scholarly journals Serum Metabolomic Profiles Identify ER-Positive Early Breast Cancer Patients at Increased Risk of Disease Recurrence in a Multicenter Population

2017 ◽  
Vol 23 (6) ◽  
pp. 1422-1431 ◽  
Author(s):  
Christopher D. Hart ◽  
Alessia Vignoli ◽  
Leonardo Tenori ◽  
Gemma Leonora Uy ◽  
Ta Van To ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Disease Recurrence ◽  
Breast Cancer Patients ◽  
Increased Risk ◽  
Er Positive ◽  
Risk Of Disease
Sign in / Sign up

Export Citation Format

Share Document